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Tracing amyloid in Alzheimer's
Chemistry World ^ | 14 October 2009 | Phil Taylor

Posted on 10/15/2009 12:40:26 AM PDT by neverdem

A diagnostic compound that allows researchers to look into the brains of Alzheimer's patients will be used for the first time to gauge the effects of an experimental therapy for the disease. 

Called florbetaben, the diagnostic could also provide important insights into the role of beta amyloid, a protein that accumulates into plaques in the brains of patients with Alzheimer's disease and has been shown to be toxic to nerve cells. 

The compound is an 18F-radiolabelled tracer that binds specifically to deposits of beta amyloid, and can be measured using positron emission tomography (PET), a nuclear imaging technique which produces a three-dimensional image of functional processes in the body. 

In living patients, diagnosis of Alzheimer's currently relies on a mix of cognitive testing and magnetic resonance imaging (MRI) and computed tomography (CT) scans to exclude other forms of dementia, but is only 70 to 80 per cent reliable. 

"A safe diagnosis of Alzheimer's is currently only possible post-mortem - florbetaben could help differentiate people with Alzheimer's from healthy individuals"

'MRI and CT only allow for the imaging of anatomic compositions of the body, such as organs,' a spokesperson for Bayer Schering Pharma, the company behind the development of florbetaben, told Chemistry World. 'More recently, PET scans are increasingly being read alongside CT or MRI to allow anatomic and structural or molecular information to be gathered at the same time.' 

A definitive diagnosis of Alzheimer's relies on the presence of beta amyloid plaques and other hallmarks of the disease in brain tissue samples examined under the microscope.  

'A safe diagnosis of [Alzheimer's] is currently only possible post-mortem,' the spokesperson commented. 

Data presented earlier this year from a Phase II trial suggested florbetaben could be used to differentiate people with Alzheimer's from healthy volunteers of the same age. 

In the latest study, florbetaben will be used to see whether a vaccine developed by Swiss company AC Immune, designed to stimulate the immune system to break down amyloid plaques in the brain, is having the expected effect. 

The vaccine has already shown it can reduce plaque size and improve memory in animal models of Alzheimer's disease, according to Dr. Andrea Pfeifer, AC Immune's chief executive. 

'Visualising the deposition of beta amyloid that is targeted by our vaccine can be an important parameter for dose selection, and will provide useful complementary data,' she says, adding that developing diagnostics alongside therapeutics is an emerging trend in the pharmaceutical sector. 

Meanwhile, florbetaben could also be useful in establishing once and for all the role of beta amyloid in Alzheimer's disease. 

In September, Chemistry World  reported the results of a study which found that a compound called dimebolin had a beneficial effect on Alzheimer's symptoms, despite increasing levels of beta amyloid. That prompted suggestions that other forms of the protein, such as soluble amyloid oligomers, may be more neurotoxic than plaques. 

It may be too soon to reject the prevailing 'amyloid hypothesis', but tools like florbetaben could be invaluable in establishing the role of the protein once and for all. 

'A good diagnostic assay should help to evaluate the effect of new treatments in clinical trials better, as well as improve correlation of results with existing pathological and memory markers,' commented the spokesperson.  

 

 

Also of interest

alzheimers-brain-scan

New drug turns Alzheimer's theory on its head

22 July 2009

An antihistamine that improves Alzheimer's symptoms has raised questions about our understanding of the disease


Alzheimer's brain scan

New technique probes Alzheimer's aggregates

14 June 2009

Scientists probe synthetic proteins to identify key toxic species responsible for Alzheimer's plaques


Alzheimer's

A metal trap to stop Alzheimer's

30 July 2008

Promising drug halts a metal-mediated chemical reaction in the brain



TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: alzheimers; alzheimersdisease; amyloid; betaamyloid

1 posted on 10/15/2009 12:40:27 AM PDT by neverdem
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To: texas booster

Ping


2 posted on 10/15/2009 12:49:57 AM PDT by neverdem (Xin loi minh oi)
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To: neverdem

Fascinating.


3 posted on 10/15/2009 1:05:20 AM PDT by TChad
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To: neverdem

Both of my parents have “old-timer’s” disease, so I’m hoping I don’t get it and start voting Democratic.


4 posted on 10/15/2009 4:15:56 AM PDT by Sender (It's never too late to be who you could have been.)
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To: neverdem

‘florbetaben’

What you get when you let Mush Mouth name the drug.


5 posted on 10/15/2009 4:40:45 AM PDT by TangoLimaSierra (To the left the truth looks Right-Wing.)
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To: neverdem

Bump.


6 posted on 10/15/2009 4:49:05 AM PDT by AdvisorB (Obamatude could be defined by Blago as something tangible, but not quite as tangible as JJJ's offer.)
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To: 1066AD; 11Bush; A.Hun; abner; AbsoluteGrace; Advil; aft_lizard; agooga; ahayes; aliquando; ...
Time for a Folding@home science ping!

Neverdem has posted a topic discussing new research avenues in Alzheimer's Disease.

Bayer has completed stage 2 trials of the drug florbetaben that works as a marker for beta amyloids in the brain, potentially allowing for a new diagnostic treatment that can be performed while the patient is still alive. Of which I am in favor.

Research in an antihistamine that improves Alzheimer's symptoms, a metal chelation therapy that traps copper ions and research into the different types of amyloids for toxicity round out as fantastic post.

*****************************************

The Folding@home team at Stanford University has a couple of updates.

First, the servers will be replaced over the next month or so by a new class of servers EACH having 48 TB of storage. This will help out greatly in keeping work units available.

Second, software upgrades to the core software is planned. Work on the GPU3 project promises speed increases on the high end video cards that some use, a new technique to speed up all cores called Normal Mode Langevin (NML) Dynamics is heading to beta, and work is progressing to allow for “simple” SMP cores in Windows and other systems.

Last, I wont to highlight some of the milestones that folders have hit in the last few weeks:

SazanEyes just hit 10,000,000 points
Klutz Dohanger is back and over 9,000,000 points
NAPA_Laurel and mouser both hit 2,000,000 points this week
Onelife hit 1,000,000 points last week
mschalock, LonePalm and HangThemHigh are all over 800,000 points
sshultz460 just hit 300,000 points
jdowntown is a new folder who has hit 40,000 points

Congrats to all, especially our new folders.

**************************************************

Current versions of clients:

Windows console and system tray: 6.23
Mac OS X: 6.26.3
Linux: 6.02 with a beta for 6.24
Playstation 3: 1.3.1

Thanks to one and all for folding!

For more information on Folding@home and how you can help save lives and advance research, please lookie here:

http://www.freerepublic.com/focus/f-chat/2316710/posts#2

7 posted on 10/15/2009 6:51:38 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: 1066AD; 11Bush; A.Hun; abner; AbsoluteGrace; Advil; aft_lizard; agooga; ahayes; aliquando; ...
Time for a Folding@home science ping!

Neverdem has posted a topic discussing new research avenues in Alzheimer's Disease.

Bayer has completed stage 2 trials of the drug florbetaben that works as a marker for beta amyloids in the brain, potentially allowing for a new diagnostic treatment that can be performed while the patient is still alive. Of which I am in favor.

Research in an antihistamine that improves Alzheimer's symptoms, a metal chelation therapy that traps copper ions and research into the different types of amyloids for toxicity round out as fantastic post.

*****************************************

The Folding@home team at Stanford University has a couple of updates.

First, the servers will be replaced over the next month or so by a new class of servers EACH having 48 TB of storage. This will help out greatly in keeping work units available.

Second, software upgrades to the core software is planned. Work on the GPU3 project promises speed increases on the high end video cards that some use, a new technique to speed up all cores called Normal Mode Langevin (NML) Dynamics is heading to beta, and work is progressing to allow for “simple” SMP cores in Windows and other systems.

Last, I wont to highlight some of the milestones that folders have hit in the last few weeks:

SazanEyes just hit 10,000,000 points
Klutz Dohanger is back and over 9,000,000 points
NAPA_Laurel and mouser both hit 2,000,000 points this week
Onelife hit 1,000,000 points last week
mschalock, LonePalm and HangThemHigh are all over 800,000 points
sshultz460 just hit 300,000 points
jdowntown is a new folder who has hit 40,000 points

Congrats to all, especially our new folders.

**************************************************

Current versions of clients:

Windows console and system tray: 6.23
Mac OS X: 6.26.3
Linux: 6.02 with a beta for 6.24
Playstation 3: 1.3.1

Thanks to one and all for folding!

For more information on Folding@home and how you can help save lives and advance research, please lookie here:

http://www.freerepublic.com/focus/f-chat/2316710/posts#2

8 posted on 10/15/2009 6:51:49 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster

BTTT


9 posted on 10/15/2009 7:20:41 AM PDT by E.G.C.
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To: texas booster

BTTT


10 posted on 10/15/2009 7:20:56 AM PDT by E.G.C.
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To: texas booster
SazanEyes just hit 10,000,000 points

He must be cheating...that is INSANE! Did he hack Deep Blue and use it for folding?

11 posted on 10/15/2009 8:44:55 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: Onelifetogive; David Park
No, SazanEyes has built a couple of computers that use the very fast NVidia GPUs to crunch 24/7.

I think that he only has 8 total computers working for us, but with the new graphics cards each of them will output 4000 - 8000 ppd.

I did a small version of it when I added a $100 NVidia card to one of my systems. Accounts for about half of my points daily.

12 posted on 10/15/2009 9:19:07 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster
I have 2 cheap nVidia cards (in 2 PCs) each putting out about 3500 ppd. (I selected them for low energy usage since I run them at home.)

I also have two SMPs running (each over 1000 ppd - One of those same nVidia machines with a quad processor and a 2 Core 2 Duo notebook.)

13 posted on 10/15/2009 9:57:58 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: Onelifetogive
2 Core 2 Duo notebook

Core 2 Duo notebook!

14 posted on 10/15/2009 9:59:37 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: texas booster

Thanks for riding herd on this; good to be apprised of progress arising out of it.

I’m scheduled hit half a million sometime around Thanksgiving.

Haven’t nosed about the forums recently; still hoping for a graphical client that plays well in the sandbox with OpenGL. Meanwhile, console clients continue apace.


15 posted on 10/15/2009 4:57:58 PM PDT by HKMk23 (In the end, life contains only one tragedy: not to have been a saint.)
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To: Sender
Well, you could just kill yourself.

But, someone else would just vote Democrat for you.

16 posted on 10/15/2009 5:00:24 PM PDT by Mr. Lucky
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To: Mr. Lucky

Not neccessary. He can still vote Democrat after death.


17 posted on 10/15/2009 5:01:44 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: Mr. Lucky

Yeah, I would just become an ACORN-registered Democratic voter if I stopped living.


18 posted on 10/15/2009 7:17:47 PM PDT by Sender (It's never too late to be who you could have been.)
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To: HKMk23
Take a look at this link

http://protomol.sourceforge.net/

and it may help. F@H is rewriting their internal code to be more extensible and to play better with others.

ProtoMol implementation is one of their big projects and is supposed to help pass older M$ standards and greatly boost computation.

19 posted on 10/15/2009 7:37:53 PM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster

ProtoMol looks really good. Any timeline on an F@H implementation?


20 posted on 10/16/2009 12:51:33 AM PDT by HKMk23 (In the end, life contains only one tragedy: not to have been a saint.)
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To: HKMk23
As always, depends on testing.

I expect that it will be Q1 before betas are released.

21 posted on 10/16/2009 5:49:49 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster; Onelifetogive

I have about 8 PCs, but I only have two computers running F@H right now. One has four 9800GX2 video cards, and one has two 8800GS cards. I don’t do any CPU folding. I used to also fold on my PS3, but the power usage wasn’t worth it.

I’m happy that the cold weather is finally here—I don’t need to turn on the heat in the winter because the PCs heat my condo.


22 posted on 10/16/2009 12:39:18 PM PDT by David Park
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To: texas booster; All

Hi All,

I’m happily plugging away with the last computer I have left to run the program, my old PC that is doing nothing else. It has an old version of the systray client, and I was wondering if anyone knew:

If I download the new one, is the old one automatically replaced, or do I need to uninstall the old one? Also, if I do get the new client, do I loose the work unit it’s currently working on?

Thanks,


23 posted on 10/18/2009 5:47:17 AM PDT by FourtySeven (47)
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To: FourtySeven
It looks like you will have a work unit finishing in the next week. Look here to see when it is credited:

http://folding.extremeoverclocking.com/user_summary.php?s=&u=168197

I would leave the system on 24/7 until you see the work unit finish, probably just another day or so.

If you are running the system tray client, after this WU completes, stop the client, and erase it all. IIRC, there is a setting under Configure” that allows the WU to stop after completion. If you can't find it, just erase it all.

Load the most recent from here:

http://folding.stanford.edu/English/Download

The current system tray client is 6.23. It is faster than the 5.2x version and allow you to crunch more varieties of molecules. The viewer is also great.

How long have you been folding? Four or five years now? That's great.

Please ping us if we can help!

24 posted on 10/18/2009 6:22:31 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: Onelifetogive

I remember when people were hitting 3k ppd. It was like they were from the mother-ship. Like TB said, graphic cards are the only way to rack up some serious points. Even something as mundane as a 9600GSO, when overclocked, can easily produce 4k ppd. For the bigger cards, you’ll need to upgrade the computer’s power supply, but that’s a real easy change.

A while back, SazanEyes sent a link to me describing his rig. I’ll see if I can find it. It’s a freakin’ beast!!!!


25 posted on 10/18/2009 5:47:28 PM PDT by colinhester
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To: colinhester

Here’s the link to the machine that generates most of my points:
http://www.sazan.net/dpark/gauri.shtml

I don’t have any pictures of my other box online yet, but I do have various computer pictures here:
http://s722.photobucket.com/albums/ww222/sazaneyes/

Those machines are running GPUGRID and various other distributed computing projects.


26 posted on 10/19/2009 10:27:49 AM PDT by David Park
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To: texas booster

Thanks I’ll check it tonight.

Yes I’ve been folding since this project began on FR. When was that, 5 years ago already? If I had been asked before, I wouldn’t have said more than 4. It doesn’t seem that long.


27 posted on 10/19/2009 12:40:29 PM PDT by FourtySeven (47)
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