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A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.

Fascinating!

1 posted on 01/06/2010 8:07:46 PM PST by neverdem
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To: neverdem
Wolbachia are maternally inherited intracellular bacterial symbionts

Fascinating in deed.

The mother passes on these bacteria and yet it halves the life of insect.

You would think that these bacteria would have either caused the host insects to become extinct or the host would have become resistant to the bacteria.

2 posted on 01/06/2010 8:44:37 PM PST by Pontiac
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
micro ping

Viral phenomenon: Ancient microbe invaded human DNA

Team finds link between stomach-cancer bug and cancer-promoting factor

3 posted on 01/06/2010 8:47:10 PM PST by neverdem (Xin loi minh oi)
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To: neverdem

Diseases are not the only danger to humans from mosquito’s. About a year or so ago I became ill and my weight dropped from 195 down to 165 over the space of a few months. To make a long story short they eventually found a mass in my left lung and it looked like I might have lung cancer. I had surgery to remove the tumor and when they dissected it they found the mass was encapsulating two dead heartworm larvae. I researched the subject and found a couple of cases where the worms had grown to adulthood in humans.


4 posted on 01/06/2010 10:27:31 PM PST by Steel Bill
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To: neverdem

Wouldn’t DDT work just as well, without the ma$$ive re$earch effort$?

Efficacy is known, and no birdie eggshells to thin...oh right, wasn’t that disproven?


6 posted on 01/06/2010 10:52:35 PM PST by petro45acp (Free Republic, the only thing working on this sorry Bagram interweb thingy! Thanks Free Republic!)
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To: neverdem

Fruit flies are like the Atlas Van Lines of bacteria. You name it, they got it...

Funny, for an insect so tiny.


10 posted on 01/07/2010 2:42:12 AM PST by djf (What has killed more people? 1) Guns in cars or 2) Cell phones in cars???? Do the math!!!!)
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To: TenthAmendmentChampion

Ping.


12 posted on 01/08/2010 10:57:12 PM PST by nw_arizona_granny ( http://www.freerepublic.com/focus/chat/21813ht92/posts?page=1 [Survival,food,garden,crafts,and more)
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