Indeed. Justice Thomas essentially made that point in the medical marijuana case:
If the majority is to be taken seriously, the Federal Government may now regulate quilting bees, clothes drives, and potluck suppers throughout the 50 States. This makes a mockery of Madison's assurance to the people of New York that the "powers delegated" to the Federal Government are "few and defined," while those of the States are "numerous and indefinite."
J. Thomas, dissenting in Raich, 6 June 2005
Yard sales could be regulated out of existance with these idiots in charge.