Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance
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“When we don’t eat, hunger-inducing neurons in the brain start eating bits of themselves.”
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Wonder what Michelle Obama’s problem is?
Did you know that if you eat nothing but your own body, you will lose weight.
Did you know that if you eat nothing but your own body, you will lose weight.
It explains a lot about the Hollywood crowd.
Remember what the Dormouse said.
Interesting.
That starvation diets don´t work over the long haul is hardly news, but it´s always interesting to hear new hypotheses regarding the mechanisms behind apetite control.
Now, the other side of the coin is that normal apetite and metabolism is not supposed to lead to obesity, NAFLD, diabetes, etc. Hence, it is likely that the “gluttony and sloth” hypothesis of metabolic derangement is wrong.
This EJCN article outlines what I believe is the best (partial) alternative hypothesis of why we have seen such a tremendous increase in obesity, diabetes and NAFLD over the past decades (free abstract only):
http://www.nature.com/ejcn/journal/vaop/ncurrent/abs/ejcn2011132a.html
TLDR version:
“An alternative model emphasises the capacity of fructose and fructose-derived sweeteners (sucrose, high-fructose corn syrup) to perturb cellular metabolism via modification of the adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio, activation of AMP kinase and compensatory mechanisms, which favour adipose tissue accretion and increased appetite while depressing physical activity.
This conceptual model implicates chronic hyperinsulinaemia in the presence of a paradoxical state of ‘cellular starvation’ as a key driver of the metabolic modifications inducing chronic weight gain.”
Every meal should include the 6 basic food groups, caffeine, nicotine, sugar, salt, fat, and preservatives.