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A New Target In Fighting Brain Disease: Metals
WSJ ^ | 1-30-2012 | Shirlely S. Wang

Posted on 01/30/2012 4:34:33 PM PST by Dysart

Research into how iron, copper, zinc and other metals work in the brain may help unlock some of the secrets of degenerative diseases like Alzheimer's and Parkinson's.

Iron and copper appear to accumulate beyond normal levels in the brains of people with these diseases, and a new, Australian study published Sunday shows reducing excess iron in the brain can alleviate Alzheimer's-like symptoms—at least in mice.

A genetic mutation related to regulating iron is linked to ALS, or Lou Gehrig's disease. Zinc, on the other hand, appears to impair memory if its levels get too low or if it gets into a brain region where it doesn't belong, as it can with traumatic brain injury.

Research into the complicated, invisible roles these metals play in brain diseases has lagged behind study of the more-visible proteins that are damaged or clump together in the brains of Alzheimer's and Parkinson's sufferers. But better understanding metals' role in the brain could help shed light on a range of medical conditions and might offer a new route for developing treatments, scientists say.

"The field is coming around to the idea of the cause of Alzheimer's being multifactorial," and disturbed metal regulation could be one of those factors, says Ralph Nixon, chairman of the Alzheimer Association's medical and scientific advisory council and director of the Silberstein Alzheimer's Institute at New York University.

Tiny metal ions—charged particles of the elements—serve several essential functions in the body, including facilitating chemical reactions to generate energy and preserving the structure of proteins. Strict checks and balances in a healthy body keep metal levels within a tight range.

But the biological changes that come with disease and aging—as opposed to poisoning from outside sources like food, supplements or metal pans—can knock levels of these metals out of whack in the brain.

(Excerpt) Read more at online.wsj.com ...


TOPICS: News/Current Events
KEYWORDS: alzheimers; brain; braindisease; brainmetals; diseases; metals

1 posted on 01/30/2012 4:34:37 PM PST by Dysart
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To: SunkenCiv

I zinc you’ll dig this topic, ore at least won’t mine it.


2 posted on 01/30/2012 4:35:31 PM PST by Dysart ("Don't worry, it's not loaded")
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To: Dysart
They were blaming aluminum for Alzheimer's about 30 years ago. Apparently that was a dead end. Guess they have had to move on to the heavier stuff.
3 posted on 01/30/2012 4:37:54 PM PST by hinckley buzzard
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To: hinckley buzzard
They were blaming aluminum for Alzheimer's about 30 years ago. Apparently that was a dead end. Guess they have had to move on to the heavier stuff.

I haven't seen where it's been dropped as suspect, have you?

4 posted on 01/30/2012 4:47:21 PM PST by Dysart ("Don't worry, it's not loaded")
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To: Dysart; hinckley buzzard
I haven't seen where it's been dropped as suspect, have you?

Some epidemiological investigations suggested an association between chronic exposure to Al and risk of AD, although this relationship falls short of all the criteria generally attributed to causation.
5 posted on 01/30/2012 4:57:51 PM PST by aruanan
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To: Dysart

You know what? You can get the metals out. Cheaply. With over-the-counter stuff.

Yep.

DMSA, DMPS, EDTA.

Mostly the protocols are on YouTube, and they’re mostly simple. It’s liberal hippy whackos who are typically into this, however, so be prepared to sometimes hear about bike paths, or chem-trails, or about how money is bad.

I almost couldn’t stand it.

But...if you follow the protocols for 6 months or so, you’ll be fine. It’s not fast, but it is cheap and simple.

I’ll stop here cuz sometimes people tell me to shut up about this because I don’t have an M.D..


6 posted on 01/30/2012 5:01:49 PM PST by gaijin
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To: hinckley buzzard
Back to the stone age it is.

I wonder if anybody told them that stone, such as granite, contains radium and other radioactive metals?

And that radon comes from the decay of radium?

7 posted on 01/30/2012 5:06:48 PM PST by Calvin Locke
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To: aruanan

Truth is, a definitive finding of strict causation is pretty scarce in these matters...about as common as isolating specific mechanism of action in many drugs—elusive.


8 posted on 01/30/2012 5:08:03 PM PST by Dysart ("Don't worry, it's not loaded")
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To: gaijin

I’m probably going to pass.


9 posted on 01/30/2012 5:12:03 PM PST by Dysart ("Don't worry, it's not loaded")
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Looking For Donors


Click The Pic

Are You One?

10 posted on 01/30/2012 5:14:55 PM PST by DJ MacWoW (America! The wolves are here! What will you do?)
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To: Dysart

Guess what, were all going to die anyway. : P


11 posted on 01/30/2012 5:16:37 PM PST by Gasshog (going to get what all those libs asked for, but its not what they expected.)
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To: Dysart

Violent criminals tend to suffer from lack of metals in their brains and can apparently be cured by administering a few grams of lead at high velocity.


12 posted on 01/30/2012 5:55:12 PM PST by MIchaelTArchangel (Romney ruined Massachusetts. Now he wants to ruin the nation.)
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To: MIchaelTArchangel
Violent criminals tend to suffer from lack of metals in their brains and can apparently be cured by administering a few grams of lead at high velocity.

Now there's proof of causation. Cured indeed.

13 posted on 01/30/2012 6:22:00 PM PST by Dysart ("Don't worry, it's not loaded")
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To: Dysart; neverdem; decimon; AdmSmith; AnonymousConservative; Berosus; bigheadfred; Bockscar; ...

They may be onto something here — brains have giant veins in them, metal is found in giant veins... need I go on?!? ;’)

Thanks Dysart.


14 posted on 01/30/2012 7:53:21 PM PST by SunkenCiv (FReep this FReepathon!)
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