I’m only 26, so feel free to scold me, but has this ever happened before?
Ford dumped Rockefeller in ‘76. JFK was gonna dump LBJ in ‘64. FDR dumped Henry Wallace in ‘44, etc., etc.
It's happened a number of times including under Jefferson, Madison, Lincoln, and FDR with the most recent example being Angew's resignation of the VP job in 1973 under Nixon.
Then there was the Eagleton controversy back in 1972 when Democrat presidential nominee George McGovern replaced his VP nominee, Sen Tom Eagleton, midway through the campaign when Eagleton's history of psychiatric problems came to light.