I reload so I can get more velocity. I use 180’s for heavier game like elk. I have some real screaming 125 grains for varmints, but the high velocity had some keyhole effects when loaded to the max.
I prefer my .22WinMag and .223 compared to .300’s for varmints anyway.
I used .223’s for varmints and pop bottles. Works good to around 300 yards, but looses enough steam by then I don't like shooting anything bigger than a praire dog out farther.