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New bird flu strand could be linked to dead pigs in Shanghai river
WantChinaTimes.com ^ | 04/01/13 | Staff

Posted on 04/02/2013 11:51:08 AM PDT by Brian Kopp DPM

New bird flu strand could be linked to dead pigs in Shanghai river: expert

A worker cleaning up dead pigs out of the river. (Photo/Xinhua)

A worker cleaning up dead pigs out of the river. (Photo/Xinhua)

The new strand of the bird flu that has already killed two people and left another critically ill in eastern China could be linked to the thousands of dead pigs found floating in a Shanghai river last month, according to a Hong Kong infectious disease expert.

China's Ministry of Health and the National Health and Family Planning Commission announced on Sunday the world's first reported cases of the H7N9 virus, a new subtype of the avian influenza. The virus has already killed two men, aged 87 and 27, from Shanghai, while a 35-year-old woman from Anhui province remains in critical condition.

Health authorities said there is currently insufficient data to suggest that the new strand could spread among humans, especially as 88 close contacts of the three had tested negative for the virus. As of now there is no vaccine available.

Ho Pak-leung, director of the Infectious Disease Center at the University of Hong Kong, told reporters that the H7N9 cases could be related to the 10,000-plus pig carcasses that were pulled out of Shanghai's Huangpu River since early March. Local media reports attributed the mass dumping to a swine epidemic earlier in the year.

While there is no concrete evidence to suggest a definitive link between the two, the fact that the 27-year-old victim was a pork seller means health departments should collect samples of the dead pigs to see if they have been affected by the same virus, Ho said.

The previous outbreak of the highly pathogenic bird flu that first struck China in 2003 belonged to the H5 subtype, Ho said. This time the human infection appears to be different and suggests that this strand of the avian influenza might be evolving.

Ho is not the only person to draw a link between the new bird flu and the pig carcasses. Yuen Kwok-yung, a professor in the microbiology department at the University of Hong Kong, told reporters that while the H7N9 subtype should be low pathogenic, the virus could have mutated after infecting the pigs. However, Yuen urged the public not to panic until all necessary tests have been carried out.

Many of China's internet users have also drawn a direct relationship between the flu and the pigs, with some saying it is obvious that birds passed the virus to pigs, which were then consumed by humans.

Huang Li-min, the director of infection in children at National Taiwan University Hospital, said the recent deaths in China are not a coincidence and that the fatality rate could be high if the virus turns out to be highly pathogenic. The virus does not necessarily have to go from bird to pig to human; it is possible that the virus could be transmitted directly from birds to humans, Huang said, adding that at this stage, the disease should be controllable as long as it is not spread from human to human.



TOPICS: Foreign Affairs; News/Current Events
KEYWORDS: birdflu; h7n9; microbiology

1 posted on 04/02/2013 11:51:08 AM PDT by Brian Kopp DPM
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To: Smokin' Joe
Something to keep an eye on: new H7N9 avian flu with genetic mutations to infect humans.

Commentary

H7 Q226L In Shanghai and Anhui H7N9 Cases
Recombinomics Commentary 20:15
April 1, 2013
The recent H7N9 cases in China have caused considerable concern.  This serotype had never been found in humans previously and only one fatal bird flu case that was not H5N1 had been reported (H7N7 in The Netherlands in 2003.  Two of the H7N9 cases were fatal (87M and 27M), while one was critical (35F).

The WHO Chinese Influenza Research Center released a full set of sequences for all three cases.  Each had PB2 E627K, as well as a 15 BP deletion In N9.  PB2 E627K is a mammalian adaptation and was present in both H5N1 transmission experiments (CDC and EMC) which used an avian PB2.

All three of the H5N1 transmission studies introduced the receptor bind domain change Q226L to increase affinity for mammalian receptors. 

Q226L has never been reported in natural H5N1 isolates.

Two of the H7N9 cases, A/Shanghai/2/2013 and A/Anhui/1/2013 have Q226L, raising serious pandemic concerns.


2 posted on 04/02/2013 11:53:35 AM PDT by Brian Kopp DPM ("Hey, I'm just being humble. You know, like Pope Francis. Stop being a Pharisee.")
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To: Dr. Brian Kopp; neverdem; ProtectOurFreedom; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; ...
Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

So far the false positive rate is 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

3 posted on 04/02/2013 11:58:45 AM PDT by null and void (Gun confiscation enables tyranny. Republicans create the tools of oppression and Democrats use them.)
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To: Dr. Brian Kopp

Ho Hum


4 posted on 04/02/2013 12:00:06 PM PDT by Safetgiver ( Islam makes barbarism look genteel.)
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To: Dr. Brian Kopp
However, Yuen urged the public not to panic until all necessary tests have been carried out.

So we are supposed to panic, just not yet.

5 posted on 04/02/2013 12:01:55 PM PDT by nitzy (You can avoid reality but you can't avoid the consequences of avoiding reality.)
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To: Dr. Brian Kopp

This strain would be a kick in the tail...our vaccines are geared to H1N1 strains. I watched H3N8 jump species and it was a over a year before anyone got a handle on the disease.


6 posted on 04/02/2013 12:04:15 PM PDT by vetvetdoug
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To: Safetgiver

I wonder how involved our CDC is involved. If so, treat information from this like the plague. They are incompetent poltical functionaries.


7 posted on 04/02/2013 12:04:46 PM PDT by Gaffer
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To: nitzy

I think when you live in a country where thousands of dead pigs can be found floating in the river, you should always be prepared to panic at a moment’s notice.


8 posted on 04/02/2013 12:13:33 PM PDT by Boogieman
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To: null and void

The virus does not necessarily have to go from bird to pig to human; it is possible that the virus could be transmitted directly from birds to humans, Huang said, adding that at this stage, the disease should be controllable as long as it is not spread from human to human.

Should be controllable...I somehow find no solace in
that statement.


9 posted on 04/02/2013 12:14:55 PM PDT by tet68 ( " We would not die in that man's company, that fears his fellowship to die with us...." Henry V.)
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To: Boogieman
I think when you live in a country where thousands of dead pigs can be found floating in the river, you should always be prepared to panic at a moment’s notice.

This is how World War Z starts.

10 posted on 04/02/2013 12:21:54 PM PDT by DCBryan1
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To: Boogieman
I think when you live in a country where thousands of dead pigs can be found floating in the river, you should always be prepared to panic at a moment’s notice.

It does make it look like a filthy and disease ridden place, doesn't it? Do they get drinking water from that river? Sounds like a disgusting place.
11 posted on 04/02/2013 12:23:45 PM PDT by ZX12R (Never forget the heroes of Benghazi, who were abandoned to their deaths by Obama)
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To: ZX12R

I guess it’s still slightly better than the Ganges, where they regularly dump HUMAN bodies in the main water source for millions of people.


12 posted on 04/02/2013 12:31:06 PM PDT by Boogieman
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To: Dr. Brian Kopp
Local media reports attributed the mass dumping to a swine epidemic earlier in the year.

Imagine someone selfish enough to throw thousands of pigs into a river to float his problems on everyone downstream.

Imagine people drinking water from that river.

Communism is the most selfish of governments in history, with the most hypocritical history of being "for the people".

13 posted on 04/02/2013 12:33:30 PM PDT by American in Israel (A wise man's heart directs him to the right, but the foolish mans heart directs him toward the left.)
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To: Dr. Brian Kopp

Angry Birds!


14 posted on 04/02/2013 12:40:16 PM PDT by informavoracious (God help us.)
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To: Boogieman
I guess it’s still slightly better than the Ganges, where they regularly dump HUMAN bodies in the main water source for millions of people.

I've seen pictures of what you speak. And people still go swimming, washing and drinking among the carcasses. India is another filthy hellhole.
15 posted on 04/02/2013 12:42:00 PM PDT by ZX12R (Never forget the heroes of Benghazi, who were abandoned to their deaths by Obama)
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To: tet68
Shanghai H7N9 Familial Cluster Chronology Supports H2H [human to human transmission]
Recombinomics Commentary 23:00
April 1, 2013

in the third case, he hadn’t left his home for two weeks before he started to get a fever. So based on what we have now, we still don’t know what the source of the infection was.”
 
According to Shanghai No. 5 People's Hospital, the three members of the Li family were admitted between February 14 and 24 for symptoms including a high fever and coughing. All three were diagnosed as having pneumonia. The 69-year-old son recovered and was discharged but the 55-year-old died from severe pneumonia and respiratory failure in late February. The father died of multi-organ failure.

The above comments indicate that the confirmed case (87M) in the above cluster has no exposure to birds or people outside of his house.  Media reports and the April 1 WHO update indicate disease onset was February 19.  This one or both of his sons (see blue above) were hospitalized prior to his disease onset, strongly suggesting that one or both were the source of his infection.  Both sons had similar systems and one (55M) died (as did the father, 87M).
 
These dates and contacts signal human to human transmission in this family, as expected from the sequences from the three confirmed cases, which include the 87M.  All three have PB2 E627K as well as a 15 BP deletion in N9.  Two of the confirmed cases, A/Shanghai/2/2013 and A/Anhui/1/2013 were most closely related to each other and had the receptor binding domain change Q226L, (added to all  three H5s in transmiison studies) which would likely increase human to human (H2H) transmission.  The age and collection dates for the two male confirmed cases (87M and 27M) were withheld.  However samples as usually number chronologically, so it is likely that A/Shanghai/1/2013 is from the 87M, since his disease onset was more than a week earlier than the unrelated case (27M).

Regardless of the assignment, the above bird flu H7N9 cluster strongly suggests that all three family members were infected and one or both sons infected their father. 

Although WHO maintains there is no evidence of  H2H based on confirmed cases, the above cluster has disease onset dates that support H2H transmission, as expected due to the genetic changes in these sequences.

16 posted on 04/02/2013 12:44:03 PM PDT by Brian Kopp DPM ("Hey, I'm just being humble. You know, like Pope Francis. Stop being a Pharisee.")
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To: informavoracious

17 posted on 04/02/2013 12:45:45 PM PDT by Brian Kopp DPM
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To: informavoracious

18 posted on 04/02/2013 12:46:25 PM PDT by Brian Kopp DPM
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To: Gaffer

Abortions cause $55 of all breast cancer. Studies are there, I’m not going back to look for them. Ever hear the CDC say crap about that? NOOOO, of course not.


19 posted on 04/02/2013 12:48:02 PM PDT by Safetgiver ( Islam makes barbarism look genteel.)
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To: Safetgiver

55%, asshat.


20 posted on 04/02/2013 12:49:12 PM PDT by Safetgiver ( Islam makes barbarism look genteel.)
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To: Dr. Brian Kopp
Is This a Pandemic Being Born?

BY LAURIE GARRETT | APRIL 1, 2013

China's mysterious pig, duck, and people deaths could be connected. And that should worry us.

On March 25, Chinese authorities seized manufactured pork buns that were found to be made from Zhejiang pigs that had died of the mysterious ailment. The possibly contaminated pork was in the Chinese food supply. By the end of March, at least 20,000 pig carcasses and tens of thousands of ducks and swans had washed upon riverbanks that stretch from the Lake Qinghai area all the way to the East China Sea -- a distance roughly equivalent to the span between Miami and Boston. Nobody knows how many more thousands of birds and pigs have died, but gone uncounted as farmers buried or burned the carcasses to avoid reprimands from authorities.
While environmental clean-up and agricultural authorities scrambled to remove the unsightly corpses and provide the anxious public with less-than-believable explanations for their demise, a seemingly separate human drama was unfolding. On Feb. 19, a man identified by Xinhua, China's state news agency, only as Li, an 87-year old retiree, was hospitalized in Shanghai with severe respiratory distress and pneumonia. On March 4, Li went into severe cardio-respiratory failure and succumbed.
On Feb. 27, a man identified only as Wu, a 27-year-old butcher or meat processor, fell ill with respiratory distress, was hospitalized, and died on March 10. The day Wu succumbed a third individual, a 35-year-old woman identified as Han, was hospitalized in the city of Nanjing, though she came from distant Chuzhou City, in Anhui province, about 300 miles northwest of Shanghai. Han is reportedly in critical condition, in intensive care. To date, no connection between the three individuals has been found.
The elderly Li may have been part of a family cluster of illness, as his 55-year old son died of pneumonia in March, and another 67-year-old son suffered respiratory distress, but has survived.
On March 31 -- Easter in the United States -- China's newly created National Health and Family Planning Commission (which includes the former Ministry of Health) announced that 87-year-old Li, Wu, and Han all were infected with a form of influenza denoted as H7N9 -- a type of flu never previously known to infect human beings. The commission insisted that Li's two sons (one dead, the other a survivor) were not infected with the flu virus -- their ailments were reportedly coincidental, though they occurred at the same time as the elder Li's demise.
So much for the backstory: What is going on?

21 posted on 04/02/2013 1:18:44 PM PDT by Brian Kopp DPM
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To: Dr. Brian Kopp

Nah! Rotting carcass’ in water never caused any problems!


22 posted on 04/02/2013 1:20:05 PM PDT by vpintheak (Occupy your Brain!)
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To: vetvetdoug

Yet they keep telling us that diseases can’t jump species - Yes, it can! No, it can’t! Yes, it can! Yes, it can! Yes, it can!!!

I’ve noticed that the pictures of the pigs they’ve been showing over the past few weeks have been small pigs. Either they on’t have the large breeds we do here or the disease is striking younger ones.


23 posted on 04/02/2013 1:39:24 PM PDT by bgill
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To: ZX12R

Yeah, it’s not too surprising that they still have outbreaks of the bubonic plague there.


24 posted on 04/02/2013 4:13:28 PM PDT by Boogieman
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To: Dr. Brian Kopp
Aren't these influenzas that combine bird flu with mammals (I'm not a scientist, clearly) far more dangerous to humans than the typical influenzas?

For all those who may be taking this lightly, we shouldn't discount the seriousness of this virus simply because we are seeing it so soon in its life. The speed of modern communication has somewhat unfortunately caused many of us to be cynical.

25 posted on 04/02/2013 4:24:18 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: trisham

Yes, this new one has already picked up genetic segments, apparently from exposure in pigs, that makes it better at surviving and reproducing in mammalian (including human) respiratory tracts. They’ve never seen these gene segments in this type of avian flu outbreak in humans.


26 posted on 04/02/2013 4:34:42 PM PDT by Brian Kopp DPM
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To: Dr. Brian Kopp
Yes, this new one has already picked up genetic segments, apparently from exposure in pigs, that makes it better at surviving and reproducing in mammalian (including human) respiratory tracts. They’ve never seen these gene segments in this type of avian flu outbreak in humans.

*****************************

I'm very concerned about this outbreak. In the past, I've not been apprehensive, but this strain may be the one that puts all previous nonchalance to rest.

27 posted on 04/02/2013 4:42:43 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: trisham; Dr. Brian Kopp; null and void; neverdem; Smokin' Joe; bgill

China confirms 4 more cases of H7N9 bird flu

FOUR people in eastern Jiangsu Province have been confirmed as being infected with the lesser-known H7N9 bird flu, bringing the total number of infections in the country to seven.

The four, from four cities in Jiangsu, are in a critical condition and under emergency treatment, the provincial health bureau said in a statement yesterday.

The four were confirmed as having H7N9 avian influenza by an expert team summoned by the provincial health bureau, based on clinical observations, laboratory tests and epidemiological surveys, the statement said.

http://www.shanghaidaily.com/nsp/National/2013/04/03/China%2Bconfirms%2B4%2Bmore%2Bcases%2Bof%2BH7N9%2Bbird%2Bflu/


28 posted on 04/02/2013 8:04:33 PM PDT by LucyT
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To: LucyT; trisham
H7N9 Chinese Avian Flu Virus May Have Adapted To Mammals

Helen Branswell, The Canadian Press
04/02/2013 8:57 pm EDT

Excerpt:

The new flu virus that has exploded onto the global radar is already showing signs that it is adapting to mammals, suggesting what was once a bird virus is now probably spreading in a mammalian host, an influenza expert said Tuesday.

And while it's not clear what that mammalian host is, the two most obvious choices are pigs or humans, said Dr. Richard Webby, head of the World Health Organization's influenza collaborating centre at St. Jude Children's Research Hospital in Memphis, Tenn.

"I think that's what's concerning about this ...This thing doesn't any longer look like a poultry virus," Webby, a swine flu expert, said in an interview.

"It really looks to me like it's adapted in a mammalian host somewhere."

29 posted on 04/02/2013 8:11:23 PM PDT by Brian Kopp DPM
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To: Dr. Brian Kopp
This thing doesn't any longer look like a poultry virus," Webby, a swine flu expert, said in an interview. "It really looks to me like it's adapted in a mammalian host somewhere."

Not good. Just wait until it hops on an airplane headed to LA.

30 posted on 04/02/2013 8:48:06 PM PDT by bgill
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To: LucyT

Thanks for the ping.


31 posted on 04/02/2013 10:23:49 PM PDT by neverdem ( Xin loi min oi)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (Thanks Dr. Brian Kopp!)


32 posted on 04/03/2013 1:47:25 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: LucyT

Yikes! My husband’s brother was in China on business and saw all the pigs floating in river. What a commie hell hole.


33 posted on 04/03/2013 4:13:15 AM PDT by penelopesire (TIME FOR OBAMA TO ANSWER FOR BENGHAZI UNDER OATH!!)
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To: Safetgiver
Ho Hum

That's easy for you to say.

We all died of this last year.

34 posted on 04/03/2013 4:31:22 AM PDT by MARTIAL MONK (I'm waiting for the POP!)
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To: Dr. Brian Kopp

For a little clarity, the “H7” in its nomenclature stands for “Hemagglutinin (HA) type 7”. There are at least 17 different HA antigens, numbered 1-17.

The first three hemagglutinins, H1, H2, and H3, are found in easily transmissible among people, human influenza viruses.

H1N1 was the type of flu that caused the Spanish Flu in 1918, killing millions around the world. But iterations of H1N1 since have been limited by “near immunity” in most people. The recent exception being the Ukraine H1N1 flu epidemic, which traumatized that region, with some of the dead having lungs so damaged they looked black and burned.

However, the flu with the most potential for an epidemic the likes of which has never been seen on Earth, the potential “thermonuclear bomb” of influenza, is H5N1.

A highly pathogenic avian flu virus of H5N1 type has been found to infect humans at a low rate. It has been reported that single amino acid changes in this avian virus strain’s type H5 hemagglutinin have been found in human patients that “can significantly alter receptor specificity of avian H5N1 viruses, providing them with an ability to bind to receptors optimal for human influenza viruses”.

And no one has even limited immunity to H5N1. There is no vaccine for it.

Which brings us to the other side of the equation, the “N” factor, which stands for “Neuraminidase”. There are at least 200 known kinds, the first four of which (N1-N4) have been around so long that parts of them have been integrated into the human genome. There are five other “N” factor subtypes, but only N1 and N2 are commonly found in people.

Put simply, the “H” factor is how the virus enters host cells, and after reproducing inside them and killing the cell, the “N” factor is how they get out of the dead cell before it is destroyed by the body.

All anti-viral drugs are designed to inhibit the “N” factor, to keep the virus trapped inside the cell until it is destroyed along with them.

While it is much less likely to become incredibly transmissible between humans, yet still retain lethality, like H5N1, H7N9 does have possibilities, perhaps by swapping genetic information with other influenza viruses.


35 posted on 04/03/2013 6:52:46 AM PDT by yefragetuwrabrumuy (Best WoT news at rantburg.com)
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To: nitzy

Let’s panic next Tuesday. I have a rough week cut out for me.


36 posted on 04/03/2013 6:53:09 AM PDT by txhurl
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To: Boogieman
Yeah, it’s not too surprising that they still have outbreaks of the bubonic plague there.

We have it in the western US as well.

37 posted on 04/03/2013 7:12:37 AM PDT by null and void (Gun confiscation enables tyranny. Republicans create the tools of oppression and Democrats use them.)
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To: null and void

“We have it in the western US as well.”

Well, I’m gonna blame that on rodents from Mexico illegally immigr... I mean “seeking a better life”.


38 posted on 04/03/2013 7:48:06 AM PDT by Boogieman
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To: Boogieman
Well, I’m gonna blame that on rodents from Mexico illegally immigr... I mean “seeking a better life”.

Credit where credit is due:

In the 1850's there was a Plague outbreak in San Fransisco's Chinatown.

It was detected early on by a local physician, who promptly reported it to City Hall, and recommended a rat catching program, quarantine, and general clean up of the area.

The city fathers refused to acknowledge that there was Plague in their fair city. It festered until the problem could no longer be ignored, and finally a cleanup of Chinatown was instituted.

But by then Plague had spread from the rats to the ground squirrel population. Now one can be exposed to the Plague anywhere in the western US.

Feel free to draw parallels to any more recent plagues...

39 posted on 04/03/2013 8:12:01 AM PDT by null and void (Gun confiscation enables tyranny. Republicans create the tools of oppression and Democrats use them.)
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To: null and void

Ah, that makes sense. If it was in the rat population, well they can only survive in proximity to us, so we could control it. With squirrels, we’ve got no such luck. Good thing I don’t live out West, because I like to feed the squirrels, they’re my buds :)


40 posted on 04/03/2013 3:46:28 PM PDT by Boogieman
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To: trisham
Aren't these influenzas that combine bird flu with mammals (I'm not a scientist, clearly) far more dangerous to humans than the typical influenzas?

All influenzas are thought to originate in birds. The problem when a new influenza emerges is that our immune systems have never seen it before, so it takes longer to mount an immune response and the disease becomes more severe. Another problem can be that the immune system (the innate system that is always there, not the antibody system) overreacts, causing a "cytokine storm" that kills. The cytokine storms are thought to be the major factor in why so many people died when the H1N1 virus first emerged, back in 1918. Now, almost a century later, H1N1 is not nearly as lethal. Even "typical" influenzas can have a fairly high death rate--but are still pretty mild when compared to the 1918 flu.

41 posted on 04/03/2013 5:19:12 PM PDT by exDemMom (Now that I've finally accepted that I'm living a bad hair life, I'm more at peace with the world.)
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To: Smokin' Joe

Thanks for the ping!


42 posted on 04/03/2013 8:45:48 PM PDT by Alamo-Girl
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To: Alamo-Girl

You’re welcome, Alamo-Girl!


43 posted on 04/03/2013 10:10:01 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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Comment #44 Removed by Moderator

To: Gaffer
I wonder how involved our CDC is involved. If so, treat information from this like the plague. They are incompetent poltical functionaries.

Not my experience.

45 posted on 04/04/2013 2:19:35 PM PDT by Lazamataz ("AP" clearly stands for American Pravda. Our news media has become completely and proudly Soviet.)
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To: null and void

Government?


46 posted on 04/06/2013 4:14:14 AM PDT by 1010RD (First, Do No Harm)
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To: Lazamataz

AP stands for Assumed Propaganda.


47 posted on 04/06/2013 4:14:45 AM PDT by 1010RD (First, Do No Harm)
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To: Boogieman
I think when you live in a country where thousands of dead pigs can be found floating in the river,

I wonder how the fishing is........

China is a toxic waste dump......

48 posted on 04/06/2013 4:17:56 AM PDT by Hot Tabasco (This space for rent)
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To: Lazamataz

I guess you never got one of their Swine Flu shots of the mid seventies.


49 posted on 04/06/2013 10:08:48 AM PDT by Gaffer
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To: ex-Texan

Posting infowars content via a blog does not make it any more suitable for FR.

Knock off posting infowars here. You know better, yet you persist.


50 posted on 04/08/2013 8:25:10 AM PDT by Admin Moderator
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