Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Drug Appears To Work For Weight-Loss In U-M Study
CBS News ^ | July 1, 2013 | NA

Posted on 07/01/2013 8:18:52 PM PDT by neverdem


Obese mice were given the drug Amlexanox lost weight. (credit: University of Michigan)

ANN ARBOR (WWJ) - Could a drug used to treat canker sores be a miracle weight-loss solution? Researchers at University of Michigan are working to find out.

Back in February, U-M researchers discovered that mice given the prescription drug, Amlexanox, lost weight without diet or exercise.

Now, Dr. Elif Oral, an associate professor of internal medicine at U-M’s Metabolism, Endocrinology & Diabetes (MEND) division, is beginning the first human study to determine whether the drug will have the same effect in people.

“The weight loss together in improved glucose metabolism makes this even more interesting, you know, and more exciting,” Oral told WWJ Health Reporter Sean Lee. “We’re going to start out by targeting the diabetic population because that’s the population that needs more immediate help.”

The study is small, enrolling just 10 obese people with Type 2 diabetes. If that goes well, the next study will enroll more people.

For more information about volunteering, call 734-615-0539 or visit this link.


TOPICS: Culture/Society; News/Current Events
KEYWORDS: amlexanox; cankersores; diabetes; obesity; type2diabetes; weight; weightloss

1 posted on 07/01/2013 8:18:52 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

Know what really works like a charm for weight loss? Exercising and eating less. It’s the magic formula. I lost 22 lbs in four months that way.


2 posted on 07/01/2013 8:23:51 PM PDT by GreatRoad (O < 0)
[ Post Reply | Private Reply | To 1 | View Replies]

To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

FReepmail me if you want on or off the diabetes ping list.

3 posted on 07/01/2013 8:24:00 PM PDT by neverdem (Register pressure cookers! /s)
[ Post Reply | Private Reply | To 1 | View Replies]

To: cripplecreek

Ann Arbor is looking for recruits.


4 posted on 07/01/2013 8:27:06 PM PDT by neverdem (Register pressure cookers! /s)
[ Post Reply | Private Reply | To 3 | View Replies]

To: GreatRoad

radiation and chemo also work.


5 posted on 07/01/2013 8:29:15 PM PDT by RitchieAprile
[ Post Reply | Private Reply | To 2 | View Replies]

To: RitchieAprile

Sorry.


6 posted on 07/01/2013 8:30:44 PM PDT by doc1019 (There is absolutely no difference between pro-choice and pro-abortion.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: neverdem

The problem is inactivity and overeating. Diet and processed foods are a huge problem. But if this is a disease, it’s caused by consumerism and federal welfare.

Back in the early 90’s I worked at Safeway. Mothers brought in WIC cards for milk. People paid for foodstuffs with paper food stamps. There was a built-in humility that made people want to avoid the situation.

It’s the same humility that could have held single parenthood in check. Well, if no-fault divorce wasn’t possible.


7 posted on 07/01/2013 8:30:46 PM PDT by andyk (I have sworn...eternal hostility against every form of tyranny over the mind of man.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: RitchieAprile

I’m really sorry.


8 posted on 07/01/2013 8:35:50 PM PDT by andyk (I have sworn...eternal hostility against every form of tyranny over the mind of man.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: Spunky

Ping to self for later reading.


9 posted on 07/01/2013 8:36:48 PM PDT by Spunky
[ Post Reply | Private Reply | To 1 | View Replies]

To: GreatRoad

Just eating less works too. I’ve done it . no exercise. I know the media is pushing the exercise thing.


10 posted on 07/01/2013 8:40:18 PM PDT by Democrat_media (IRS rigged election for Obama and democrats by shutting down tea party)
[ Post Reply | Private Reply | To 2 | View Replies]

To: GreatRoad
Know what really works like a charm for weight loss?

Exlax and prune juice?

11 posted on 07/01/2013 8:54:29 PM PDT by umgud (2A can't survive dem majorities)
[ Post Reply | Private Reply | To 2 | View Replies]

To: GreatRoad

“Exercising and eating less. It’s the magic formula.”

Yup...works every time...and when they tell you it does not work, they are lying...


12 posted on 07/01/2013 9:01:26 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders)
[ Post Reply | Private Reply | To 2 | View Replies]

To: RitchieAprile
radiation and chemo also work.

So does stress, grief and worry.

Eating comes to a complete stop.

13 posted on 07/01/2013 9:04:35 PM PDT by Lizavetta (You get what you tolerate)
[ Post Reply | Private Reply | To 5 | View Replies]

To: neverdem

I’ve lost exactly 40 pounds since the first of the year ( started at 222 and now I am 182 ). My secret ? I gave up beer and soda and stopped stuffing my face with food. I don’t exactly eat healthy but just eat less than I used to. I make better choices for sure. Instead of a Big Mac I just get a plain cheeseburger. Instead of the honey bun for breakfast I choose a granola cereal and some yogurt. Simple stuff... It’s made a huge difference and the weight is still coming off !


14 posted on 07/01/2013 9:54:16 PM PDT by Bud Krieger (Another President , another idiot......)
[ Post Reply | Private Reply | To 1 | View Replies]

To: GreatRoad
Know what really works like a charm for weight loss? Exercising and eating less. It’s the magic formula. I lost 22 lbs in four months that way.

I tried that and actually made some good progress until I plateaued. Then I went to a low-carb diet and immediately started losing again. Whatever the case, once you hit a certain age and a certain level of weight gain, exercise alone doesn't cut it; you've got to lower the caloric intake as well.

15 posted on 07/01/2013 10:09:49 PM PDT by Mr Ramsbotham (Laws against sodomy are honored in the breech.)
[ Post Reply | Private Reply | To 2 | View Replies]

To: GGpaX4DumpedTea
This works well too.


16 posted on 07/01/2013 10:46:24 PM PDT by itsahoot (It is not so much that history repeats, but that human nature does not change.)
[ Post Reply | Private Reply | To 12 | View Replies]

To: itsahoot

Divorce works well.


17 posted on 07/01/2013 11:00:08 PM PDT by jb257mag
[ Post Reply | Private Reply | To 16 | View Replies]

To: neverdem

Thinner......


18 posted on 07/01/2013 11:01:39 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
[ Post Reply | Private Reply | To 1 | View Replies]

To: jb257mag

Specially if you drink a lot and forget to eat while you are chasing replacements.


19 posted on 07/01/2013 11:09:35 PM PDT by itsahoot (It is not so much that history repeats, but that human nature does not change.)
[ Post Reply | Private Reply | To 17 | View Replies]

To: GreatRoad

Another miracle cure we’ll never hear of again.


20 posted on 07/01/2013 11:17:35 PM PDT by daler
[ Post Reply | Private Reply | To 2 | View Replies]

To: GGpaX4DumpedTea

Yeah. I call it the “Quit Eating So Damn Much” diet.


21 posted on 07/02/2013 12:21:21 AM PDT by DigitalVideoDude (It's amazing what you can accomplish when you don't care who gets the credit. -Ronald Reagan)
[ Post Reply | Private Reply | To 12 | View Replies]

To: daler

It causes cancer. Run for your life.

For canker sores put salt in the wound, sure it hurts but it heals more rapidly.

That will be a $100.


22 posted on 07/02/2013 5:58:25 AM PDT by urbanpovertylawcenter (where the law and poverty collide in an urban setting and sparks fly)
[ Post Reply | Private Reply | To 20 | View Replies]

To: andyk
The problem is inactivity and overeating.

Sorry, but no. If that were true, diet and exercise would succeed, but the long term success rate of diet and exercise only rarely exceeds 5%.

Obesity is a most commonly a symptom of disregulated fat metabolism. And lethargy and hunger are also symptoms of a disregulated fat metabolism.

If you fix your fat metabolism, you will eat less because you won't be hungry all the time, and you will exercise more, because you won't be tired all the time, and you will lose weight. But it won't be because of the diet and exercise - it will be because you addressed the actual problem.

23 posted on 07/02/2013 9:38:48 AM PDT by jdege
[ Post Reply | Private Reply | To 7 | View Replies]

To: Bud Krieger
I’ve lost exactly 40 pounds since the first of the year ( started at 222 and now I am 182 ).

In March, 2012, I weighed in at 294 pounds - and determined that I was going to lose weight. So I did what I had always done - I tried to eat less and to exercise more.

Exercise was difficult for me - I couldn't run, and I couldn't walk more than 1/4 mile before having to stop and rest due to back pain. But I pushed through, and for the next three months I was hungry and hurting and miserable.

And by June, I was down to 290 pounds.

That's when I read Gary Taubes' "Good Calories, Bad Calories", and became open to the realization that the advice I had been following, to limited success, might not be all that good.

So I started a strict low-carb diet, and stopped exercising, as is generally advised for the first couple of weeks of low-carb.

The results were immediate and dramatic. After two weeks, without exercise, and before I'd lost much weight, I was out walking the dog, and suddenly realized that I'd walked more than five miles, without back pain. Which I hadn't been able to do in fifteen years.

I had more energy, I slept better. My sleep apnea and acid reflux disappeared. My blood pressure normalized, and I came off my blood pressure meds.

Exercise became easy - and productive. I was no longer driving myself and seeing no results.

And the weight came off steadily.

I started on June 11, at 289 pounds. By July 1 I was at 280, 270 by August 1, 260 by September 1. By January 1, 2013, I was down to 220.

Since then I've been engaged in a weight training program. I've seen considerable continuing fat loss, but my weight has been more steady. As of this morning I'm down to 216. (I'm 6'1", and I've put on a fair amount of muscle. My current ideal weight is 195-205 pounds - which means I've yet got a bit to go, but I'm getting close.)

And through this all I've never gone hungry. I've eaten whenever I felt the need, as much as I felt the need. I've never consciously restricted calories. And I've completely given up on the hours of endless cardio exercise. I'm exercising intensely, but for less than an hour, two or three times a week. And I'm seeing results that I never had, back before I adopted low carb.


24 posted on 07/02/2013 10:47:49 AM PDT by jdege
[ Post Reply | Private Reply | To 14 | View Replies]

To: neverdem

Haven’t we made life safe for all mice?


25 posted on 07/03/2013 3:36:18 AM PDT by 1010RD (First, Do No Harm)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Fiddling with your body chemistry? No thanks. I’m getting results with calorie restriction, cardio, and strength training. And the girlies are starting to notice me again. ;)


26 posted on 07/03/2013 3:38:37 AM PDT by Lazamataz (If illegal aliens voted (R), then the Dems would create the tightest border security in the world.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: RitchieAprile
radiation and chemo also work.

I've found that a good bout of the flu works wonders!

27 posted on 07/03/2013 3:39:21 AM PDT by Lazamataz (If illegal aliens voted (R), then the Dems would create the tightest border security in the world.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: Bud Krieger
Simple stuff... It’s made a huge difference and the weight is still coming off !

My target weight is three ounces.

Well on the way!

28 posted on 07/03/2013 3:40:22 AM PDT by Lazamataz (If illegal aliens voted (R), then the Dems would create the tightest border security in the world.)
[ Post Reply | Private Reply | To 14 | View Replies]

To: jdege

You go!


29 posted on 07/03/2013 3:40:58 AM PDT by Lazamataz (If illegal aliens voted (R), then the Dems would create the tightest border security in the world.)
[ Post Reply | Private Reply | To 24 | View Replies]

To: neverdem

Though exponentially more expensive, to the tune of half your house and other shit, divorce is the best weight loss retiming.


30 posted on 07/03/2013 3:57:26 AM PDT by DainBramage
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson