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LSUHSC research finds combo of plant nutrients kills breast cancer cells
Louisiana State University Health Sciences Center ^ | 22-Nov-2013 | Louisiana State University Health Sciences Center

Posted on 11/30/2013 2:55:57 PM PST by xzins

Contact: Leslie Capo lcapo@lsuhsc.edu 504-568-4806 Louisiana State University Health Sciences Center

LSUHSC research finds combo of plant nutrients kills breast cancer cells

New Orleans, LA – A study led by Madhwa Raj, PhD, Research Professor in Obstetrics and Gynecology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a super cocktail of six natural compounds in vegetables, fruits, spices and plant roots killed 100% of sample breast cancer cells without toxic side effects on normal cells. The results, which also revealed potential treatment target genes, are published in the November 2013 issue of The Journal of Cancer.

"One of the primary causes of both the recurrence of breast cancer and deaths is a small group of cancer stem cells that evade therapy," notes Dr. Raj. "These often multi-drug-resistant cells have the ability to generate new tumors, so it is critically important to develop new approaches to more effective and safer treatment or prevention of breast cancer."

The research team tested ten known protective chemical nutrients found in foods like broccoli, grapes, apples, tofu, and turmeric root (a spice used in Indian curry) before settling upon six – Curcumin known as tumeric, Isoflavone from soybeans, Indo-3-Carbinol from cruciferous plants, C-phycocyanin from spirulina, Reservatrol from grapes, and Quercetin, a flavonoid present in fruits, vegetables, and tea. The researchers administered these six at bioavailable levels to both breast cancer and control cells. They tested the compounds individually and in combination. They found that the compounds were ineffective individually. When combined, though, the super cocktail suppressed breast cancer cell growth by more than 80%, inhibited migration and invasion, caused cell cycle arrest, and triggered the process leading to cell death resulting in the death of 100% of the breast cancer cells in the sample. The researchers observed no harmful effects on the control cells. Further analysis also identified several key genes, which could serve as markers to follow the progress of therapy.

Although the cocktail was not tested against BRCA1 and BRAC2, previous studies have shown that they are molecular targets of four of the six compounds. The researchers also earlier demonstrated that two of the compounds synergize effectively to kill ovarian cancer cells.

According to the National Cancer Institute's SEER Program, which includes data from LSU Health Sciences Center New Orleans, breast cancer is the second most common cancer with 232,340 new cases estimated this year and 39,620 deaths. There are an estimated 2,829,041 women currently living with breast cancer in the United States.

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The LSUHSC research team also included Andrew Hollenbach, PhD, with collaboration from David Welsh, MD, and Udai Pandey, PhD. Other local participants included Drs. Shubha Ireland at Xavier University and Shailaja Raj at Protegene Corporation.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC comprises a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. Louisiana's flagship academic health center, LSUHSC faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSUHSC research enterprise generates jobs and enormous economic impact. LSUHSC faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth


TOPICS: News/Current Events
KEYWORDS: breastcancer; breastcancerresearch; cancer; health; research
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To: xzins

My prayers and thoughts, I am so sorry.

I don’t see why a cool-steeped tea of the ingredients could be suggested to your doctors, along with this paper?


21 posted on 11/30/2013 3:49:50 PM PST by txhurl
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To: txhurl

I do intend to send this to my son. It’s a far different type of cancer, but it definitely bears thinking about.


22 posted on 11/30/2013 3:51:59 PM PST by xzins ( Retired Army Chaplain and Proud of It! Those who truly support our troops pray for victory!)
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To: xzins

I’m very sorry to hear that your grandson is ill.


23 posted on 11/30/2013 3:52:00 PM PST by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: trisham

Thank you trisham. This kind of article now catches our attention.


24 posted on 11/30/2013 3:54:11 PM PST by xzins ( Retired Army Chaplain and Proud of It! Those who truly support our troops pray for victory!)
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To: xzins

What this really shows (and I’m sure that they won’t admit it) is that a broad based natural diet is what will keep one healthy.


25 posted on 11/30/2013 4:01:39 PM PST by editor-surveyor (Freepers: Not as smart as I'd hoped they'd be)
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To: txhurl
Someone needs to market a tea of these compounds.

You're someone tx, get busy.

26 posted on 11/30/2013 4:09:30 PM PST by WVNan
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To: xzins

Tested ‘in vitro’, that is, in a test tube. The trick is to make things work ‘in vivo’, in the body. The difference is why the vast number of “cancer cures” don’t work in the body, though they do in the lab.

Cancer is a nasty. To start with, if you attack it, often it will try to protect itself. This is why oncologists use a “rule of three”, three different kinds of attacks at the same time, to overwhelm cancer’s defenses.

Using potent antioxidants, like they are doing, is also well and good, *except* most chemotherapy tries to generate oxidants inside the cancer. This means that antioxidants are fine until you get cancer, then you need to discontinue them, or they might make your other therapy less effective.

Just augmenting the immune system is also less than a good approach, because much of cancer’s defenses are based on fooling the immune system.


27 posted on 11/30/2013 4:09:46 PM PST by yefragetuwrabrumuy (Last Obamacare Promise: "If You Like Your Eternal Soul, You Can Keep It.")
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To: txhurl

let’s make our own tea! the ingredients are right in front of us!

Just get those fresh foods and eat them at the same meal.


28 posted on 11/30/2013 4:17:36 PM PST by Marcella ((Prepping can save your life today. I am a Christian, not a Muslim.))
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To: yefragetuwrabrumuy

Resveratrol it is and all this stuff is terrific but I would not take isoflavones from GMO’ed Soy. 90 % of USA soy is GMO. Not putting Monsanto, Syngenta or Bayer in charge of my boobs… flame away.


29 posted on 11/30/2013 4:17:56 PM PST by acapesket
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To: WVNan

What about Rush & FR.... tea? Twelve if by TEA?


30 posted on 11/30/2013 4:22:45 PM PST by txhurl
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To: M. Thatcher

Ping to a TEA (literally) idea.


31 posted on 11/30/2013 4:24:28 PM PST by txhurl
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To: huldah1776

Think the drug companies and doctors will allow the FDA to approve the cocktail? Nah.”

I don’t think anyone knows how many trillions of dollars we have spent and will continue to spend each year on so-called cancer research. The number of buildings constructed to allow research in places like the Houston Medical Center and the number of doctors funded by government dollars is overwhelming and continues to grow. What would all of these people do if any cures were discovered?

I often hear of progress that is being made in foreign countries but rarely hear that we make use of it in the U.S.


32 posted on 11/30/2013 4:28:51 PM PST by Grams A (The Sun will rise in the East in the morning and God is still on his throne.)
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To: xzins

BRAC2 runs in my wife’s and now our family. She’s a 20 year survivor and both of our daughters had mastectomies and chemo in the past 2 years. Now we have to worry about the grand-daughters. But this sounds good.


33 posted on 11/30/2013 4:56:55 PM PST by fella ("As it was before Noah so shall it be again,")
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To: fella

It’s hopeful. I pray God shows them a way to bring it to market and get people well. Cancer is such a scourge.


34 posted on 11/30/2013 4:58:45 PM PST by xzins ( Retired Army Chaplain and Proud of It! Those who truly support our troops pray for victory!)
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To: acapesket

I’m betting the GMO variety doesn’t give the same results. It would be a different plant...in my mind, anyway.


35 posted on 11/30/2013 5:01:54 PM PST by xzins ( Retired Army Chaplain and Proud of It! Those who truly support our troops pray for victory!)
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To: xzins

I totally agree.


36 posted on 11/30/2013 5:03:04 PM PST by acapesket
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To: editor-surveyor

There is wisdom in that, editor. GHW Bush should (honestly) take back his words about broccoli.


37 posted on 11/30/2013 5:03:30 PM PST by xzins ( Retired Army Chaplain and Proud of It! Those who truly support our troops pray for victory!)
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To: AdmSmith; AnonymousConservative; Berosus; bigheadfred; Bockscar; cardinal4; ColdOne; ...

Brought to you by Obamacare!

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https://www.google.com/search?q=don’t+need+mammograms+site%3Afreerepublic.com


38 posted on 11/30/2013 5:16:02 PM PST by SunkenCiv (http://www.freerepublic.com/~mestamachine/)
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To: SunkenCiv

Bttt


39 posted on 11/30/2013 6:55:18 PM PST by Cottonbay
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To: xzins

>> “GHW Bush should (honestly) take back his words about broccoli.” <<

.
Yes, he should!


40 posted on 11/30/2013 6:59:42 PM PST by editor-surveyor (Freepers: Not as smart as I'd hoped they'd be)
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