Skip to comments.Study: Single injection of protein could reverse symptoms of Type 2 diabetes
Posted on 07/17/2014 6:13:02 AM PDT by Innovative
When mice with the human equivalent of Type 2 diabetes were injected with the protein FGF1, their blood sugar levels returned to normal over two days. Just one injection of the protein both regulated these levels and even helped reverse insulin insensitivity the underlying cause of diabetes.
Published in the journal Nature, the research on FGF1 could revolutionize diabetes treatment.
In addition to being effective against diabetes, the protein has several advantages over current diabetes drugs. It does not result in dangerous side effects seen with other diabetes drugs, such as heart problems, weight gain, or hypoglycemia. Additionally, FGF1 not only increased insulin levels but also helped the mice regain their own ability to regulate insulin.
(Excerpt) Read more at foxnews.com ...
If diabetes can be cured, that will also eliminate all the other diseases it causes.
If this is successful, it will have to cost $10,000 per shot to make the diabetes industry happy. Diabetes is a cash cow for Big Pharma.
Rare all nine lists ping!
Cool, time to pig out baby!
That is awesome news since I happen to be Type 2. I wonder when can this injection be utilized to the public.
Type 2 diabetes is completly preventable and completly treatable with diet and exercise. And Statins are the biggest medical scam in history.
Big Pharma will be fighting.
I would GLADLY pay 10 x’s that for a shot if it worked!
It’s probably against the law to cure diabetes.
But not until Novo Nordisk finds a way to make sufficient money off of it to replace their soon-to-be useless insulin production.
Me too...Sign me up for the trial!
Exactly correct. Most of the modern metabolic degenerative diseases (heart disease, cancer, diabetes, obesity, etc) are directly related to diet.
Thanks for posting.
BS. You sound like Obama and his charge of doctors exploiting their patients with unnecessary operations. So are we supposed to conclude that "Big Pharma" is against curing Type 2 diabetes or any other disease that eats into their profits? Do you think anyone associated with "Big Pharma" has Type 2 diatetes?
I am no fan of "Big Pharma" and the deal they struck with Obama on Obamacare, but it is over the top to think that they would be unhappy with this recent news.
Type II Diabetes should need no ‘cure’.........................
Type 2 is not “completely preventable.”
The trait can be inherited.
Thanks for the link.
It doesn’t look like they are restricting who can purchase it and it’s not even very expensive, given that one dose could provide full cure.
I think what we need to find out is what is the equivalent dose for humans and how could we administer it — as in diluting in something for injection.
The researchers are using a single factor rodent diabetes knock-out model that in no way resembles the multifactorial human diabetes condition. The injected FGF1 protein simply restores the knocked-out gene function and the non-diabetic status in the now “non-knocked-out” rodent. This is a play toy that allows researchers to explore interesting secondary gene functions related to the diabetes condition. It has no implications for resolving diabetes in humans.
FWIW, I’m pre-diabetic with some insulin resistance. I got it honestly from my father who was type II, and I’m trying to avoid any pharmaceuticals, using supplements and acupuncture among other options to keep it from worsening. FGF1, as far as I can tell, affects the cell wall, which is where insulin resistance occurs, so at least it makes logical sense, though of course the body is more often counter-intuitive, and mice are not always a perfect analogue for humans.
Whatever anyone here can find out, I would be interesting in participating in.
Here is the abstract of the article in Nature — to access the full article, one has to subscribe.
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation1, 2. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis3, 4. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia. Chronic pharmacological treatment with rFGF1 increases insulin-dependent glucose uptake in skeletal muscle and suppresses the hepatic production of glucose to achieve whole-body insulin sensitization. The sustained glucose lowering and insulin sensitization attributed to rFGF1 are not accompanied by the side effects of weight gain, liver steatosis and bone loss associated with current insulin-sensitizing therapies. We also show that the glucose-lowering activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF receptor 1 signalling. Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the treatment of insulin resistance and type 2 diabetes.
Exactly right. My family has a great deal of diabetes in the family and none of them are overweight. One has Type 1 and he’s 6 ft, 145 pounds, low weight probably because of the diabetes. But don’t argue with the holier than thou. It’s always a lifestyle choice according to them.
Is there any particular food that contains FGF1?
I agree with you and others who have said the same - symptoms do not equal causality. If it were diet & exercise issue, then more half of American adults would be diabetic.
The snag is in the last paragraph of the article. They need to find a variant that doesn’t also affect cell growth. IOW, if I understand correctly, a variant that’s not carcinogenic.
Somebody tell me if I’m misunderstanding.
My dad’s side of the family had to deal with this one generation after another.
As soon as the FDA approves it.
Usually only takes fifteen or twenty years.
It is a major event; however, I hope Smiling Bob is not involved in any way.
Much appreciate the ping
A single injection of FGF1 is not going to cure diabetes in humans. A thousand injections of FGF1 are not going to cure diabetes in a human. Diabetic humans are not the same creatures as rodent diabetic knock-outs.
Or you can just go to the health food store or online and buy Alpiste (Canary Seed) and mix with water and drink twice daily. Totally organic, no side effects, high protein, flushes fat and lowers blood sugar naturally. We drink it everyday.
Does the seed stay whole or do you grind it up first?
Well you can buy the seeds then there is a process of soaking and grinding which is pretty simplistic or you can just buy the powder which is already prepared and mix it with water. Either one is about as effective as far as I can tell. We do both.
A lot of people who start drinking the canary seed milk get off the Type II Diabetes drungs after a few months. We have lost a good deal of weight already.
Thank you, will give this a go. :)
Just google canary seed milk online and you can read all about it.
No such thing as Big Pharma. If one company can bring a drug that will run its competitors out of the market they will. If another company can make something similar, they will claim their version is superior and try to take all the business from the first company.
No different than Big Electronics or Big Deodorent.
Big Electronics is always coming up with shocking current innovations that charge the economy, but Big Deodorant is just the pits.
You incorrectly assume each Pharma has control over their product availability. The FDA is in control, and the FDA has a long record of burying good products. The really big Pharma control the FDA.
Unfortunately, scientists have cures for many problems in mice. In 2008, there was a Canadian study which found the following:
Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas. "I couldn't believe it," said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. "Mice with diabetes suddenly didn't have diabetes any more."
They injected the neuropeptide "substance P" in the pancreases of diabetic mice, a demanding task given the tiny size of the rodent organs. The results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection.
I agree, the FDA moves too slowly. But on the other hand, they have cured about every disease known to man in mice and rat models. Those same treatments frequently are ineffective when tried on humans.
Won’t be of much use as high fructose corn syrup is in nearly everything.
“Type 2 diabetes is completly preventable and completly treatable with diet and exercise.”
” But dont argue with the holier than thou. Its always a lifestyle choice according to them.”
Its a religion with some people, and they are incapableintellectually and emotionallyof accepting that obesity might be a matter of lipid regulation rather than moral turpitude.
The Church of the Immoral Fatso keens incessantly like a grieving banshee that every fat deposit is punishment for the loathsome perversion of over-eating, than which no sin is greater. Every fatso is guilty! Every fatso must be punished! All scientific findings to the contrary must be treated like leftists treat liberty!
Its really not that hard to see the problem with the calories in/calories out nonsense. If not for the bigotry of the Church of the Immoral Fatso, science would be free to acknowledge the truth.
If normal people maintain a normal weight on a normal diet, and the vast majority did until recent decades, then why do some people become obese on a normal diet? The Church of the Immoral Fatso, of course, insists that all such reports are lies, and that the immoral fatsos were secretly over-eating. All scientific evidence to the contraryand theres a bunchis simply denied.
“Wont be of much use as high fructose corn syrup is in nearly everything.”
Take a page from the leftard handbook: get a federal judge to ban it.
“It doesnt look like they are restricting who can purchase it and its not even very expensive, given that one dose could provide full cure.”
The article says one dose was effective for up to four weeks.
Ain’t it the truth... Possible cures for cancer, Alzheimers, diabetes etc. Don’t want to rush them to market. Might prove harmful to terminally ill patients. /s