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Study: Single injection of protein could reverse symptoms of Type 2 diabetes
Fox News ^ | July 17, 2014 | FoxNews

Posted on 07/17/2014 6:13:02 AM PDT by Innovative

When mice with the human equivalent of Type 2 diabetes were injected with the protein FGF1, their blood sugar levels returned to normal over two days. Just one injection of the protein both regulated these levels and even helped reverse insulin insensitivity – the underlying cause of diabetes.

Published in the journal Nature, the research on FGF1 could revolutionize diabetes treatment.

In addition to being effective against diabetes, the protein has several advantages over current diabetes drugs. It does not result in dangerous side effects seen with other diabetes drugs, such as heart problems, weight gain, or hypoglycemia. Additionally, FGF1 not only increased insulin levels but also helped the mice regain their own ability to regulate insulin.

(Excerpt) Read more at foxnews.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: bloodsugar; diabetes; discovery; glucose; health; insulin; medical; medicine; proteininjection; type2
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This is such major breakthrough that I think it's worth Frontpage placement.

If diabetes can be cured, that will also eliminate all the other diseases it causes.

1 posted on 07/17/2014 6:13:02 AM PDT by Innovative
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To: Jim Robinson

ping


2 posted on 07/17/2014 6:14:07 AM PDT by Innovative ("Winning isn't everything, it's the only thing." -- Vince Lombardi)
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To: Innovative

If this is successful, it will have to cost $10,000 per shot to make the diabetes industry happy. Diabetes is a cash cow for Big Pharma.


3 posted on 07/17/2014 6:17:33 AM PDT by txrefugee
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To: Innovative; Alaska Wolf; TexasFreeper2009; DCBryan1; Slings and Arrows; Doomonyou; ...

Rare all nine lists ping!


4 posted on 07/17/2014 6:18:46 AM PDT by null and void (If Bill Clinton was the first black president, why isn't Barack Obama the first woman president?)
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To: Innovative

Cool, time to pig out baby!


5 posted on 07/17/2014 6:18:50 AM PDT by Greetings_Puny_Humans (I mostly come out at night... mostly.)
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To: Innovative

That is awesome news since I happen to be Type 2. I wonder when can this injection be utilized to the public.


6 posted on 07/17/2014 6:19:29 AM PDT by Patriot Babe
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To: txrefugee
Diabetes is a cash cow for Big Pharma.

Type 2 diabetes is completly preventable and completly treatable with diet and exercise. And Statins are the biggest medical scam in history.

Big Pharma will be fighting.

7 posted on 07/17/2014 6:20:51 AM PDT by FatherofFive (Islam is evil and must be eradicated)
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To: null and void
Reverse symptoms?.................
8 posted on 07/17/2014 6:23:16 AM PDT by Red Badger (I've posted a total of 2,763 threads and 85,286 replies. ...............)
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To: txrefugee

I would GLADLY pay 10 x’s that for a shot if it worked!


9 posted on 07/17/2014 6:23:30 AM PDT by pgkdan (ISLAM IS THE RELIGION OF THE ANTICHRIST!)
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To: Red Badger

It’s probably against the law to cure diabetes.


10 posted on 07/17/2014 6:24:21 AM PDT by null and void (If Bill Clinton was the first black president, why isn't Barack Obama the first woman president?)
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Free Republic


Click The Pic To Donate

Please Donate!

11 posted on 07/17/2014 6:25:06 AM PDT by DJ MacWoW (The Fed Gov is not one ring to rule them all)
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To: Innovative
the research on FGF1 could revolutionize diabetes treatment.

But not until Novo Nordisk finds a way to make sufficient money off of it to replace their soon-to-be useless insulin production.

12 posted on 07/17/2014 6:26:14 AM PDT by Bloody Sam Roberts (Can anyone tell me who the head of the Muslim peace movement is?)
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To: Black Agnes

Your opinion?


13 posted on 07/17/2014 6:29:08 AM PDT by who knows what evil? (Yehovah saved more animals than people on the ark...www.siameserescue.org.)
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To: Patriot Babe

Me too...Sign me up for the trial!


14 posted on 07/17/2014 6:33:35 AM PDT by Adder (No, Mr. Franklin, we could NOT keep it.)
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To: FatherofFive
Type 2 diabetes is completly preventable and completly treatable with diet and exercise. And Statins are the biggest medical scam in history.

Exactly correct. Most of the modern metabolic degenerative diseases (heart disease, cancer, diabetes, obesity, etc) are directly related to diet.

15 posted on 07/17/2014 6:34:58 AM PDT by Blennos
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To: Innovative

Thanks for posting.

Bookmark


16 posted on 07/17/2014 6:35:58 AM PDT by Aurorales (I will not be ridiculed into silence!)
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To: txrefugee
If this is successful, it will have to cost $10,000 per shot to make the diabetes industry happy. Diabetes is a cash cow for Big Pharma.

BS. You sound like Obama and his charge of doctors exploiting their patients with unnecessary operations. So are we supposed to conclude that "Big Pharma" is against curing Type 2 diabetes or any other disease that eats into their profits? Do you think anyone associated with "Big Pharma" has Type 2 diatetes?

I am no fan of "Big Pharma" and the deal they struck with Obama on Obamacare, but it is over the top to think that they would be unhappy with this recent news.

17 posted on 07/17/2014 6:39:09 AM PDT by kabar
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To: null and void

Type II Diabetes should need no ‘cure’.........................


18 posted on 07/17/2014 6:39:14 AM PDT by Red Badger (I've posted a total of 2,763 threads and 85,286 replies. ...............)
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To: Innovative
Any FReepers associated with the research industry? You could order FGF1 here and set up a 'research trial' for any of us who would be willing to try this--there's no logical reason for FGF1 to cause any ill side effects as far as I can tell...
19 posted on 07/17/2014 6:40:02 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: FatherofFive

Type 2 is not “completely preventable.”
The trait can be inherited.


20 posted on 07/17/2014 6:40:18 AM PDT by Eric in the Ozarks (Rip it out by the roots.)
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To: chajin

Thanks for the link.

http://www.prospecbio.com/FGF-1_Human_2_15/?gclid=CLL9_4y8zL8CFUEF7AodpXcAzA

It doesn’t look like they are restricting who can purchase it and it’s not even very expensive, given that one dose could provide full cure.

I think what we need to find out is what is the equivalent dose for humans and how could we administer it — as in diluting in something for injection.


21 posted on 07/17/2014 6:44:19 AM PDT by Innovative ("Winning isn't everything, it's the only thing." -- Vince Lombardi)
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To: Bloody Sam Roberts

The researchers are using a single factor rodent diabetes knock-out model that in no way resembles the multifactorial human diabetes condition. The injected FGF1 protein simply restores the knocked-out gene function and the non-diabetic status in the now “non-knocked-out” rodent. This is a play toy that allows researchers to explore interesting secondary gene functions related to the diabetes condition. It has no implications for resolving diabetes in humans.


22 posted on 07/17/2014 6:46:22 AM PDT by kruss3
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To: Innovative

FWIW, I’m pre-diabetic with some insulin resistance. I got it honestly from my father who was type II, and I’m trying to avoid any pharmaceuticals, using supplements and acupuncture among other options to keep it from worsening. FGF1, as far as I can tell, affects the cell wall, which is where insulin resistance occurs, so at least it makes logical sense, though of course the body is more often counter-intuitive, and mice are not always a perfect analogue for humans.

Whatever anyone here can find out, I would be interesting in participating in.


23 posted on 07/17/2014 6:52:15 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: kruss3

Here is the abstract of the article in Nature — to access the full article, one has to subscribe.

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13540.html

Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation1, 2. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis3, 4. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia. Chronic pharmacological treatment with rFGF1 increases insulin-dependent glucose uptake in skeletal muscle and suppresses the hepatic production of glucose to achieve whole-body insulin sensitization. The sustained glucose lowering and insulin sensitization attributed to rFGF1 are not accompanied by the side effects of weight gain, liver steatosis and bone loss associated with current insulin-sensitizing therapies. We also show that the glucose-lowering activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF receptor 1 signalling. Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the treatment of insulin resistance and type 2 diabetes.


24 posted on 07/17/2014 6:55:41 AM PDT by Innovative ("Winning isn't everything, it's the only thing." -- Vince Lombardi)
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To: Eric in the Ozarks

Exactly right. My family has a great deal of diabetes in the family and none of them are overweight. One has Type 1 and he’s 6 ft, 145 pounds, low weight probably because of the diabetes. But don’t argue with the holier than thou. It’s always a lifestyle choice according to them.


25 posted on 07/17/2014 7:03:53 AM PDT by Jenny217
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To: Innovative

Is there any particular food that contains FGF1?


26 posted on 07/17/2014 7:04:37 AM PDT by hoosiermama (Obama: "Born in Kenya" Lying now or then or now)
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To: Jenny217

I agree with you and others who have said the same - symptoms do not equal causality. If it were diet & exercise issue, then more half of American adults would be diabetic.


27 posted on 07/17/2014 7:06:20 AM PDT by Sioux-san
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To: chajin

The snag is in the last paragraph of the article. They need to find a variant that doesn’t also affect cell growth. IOW, if I understand correctly, a variant that’s not carcinogenic.

Somebody tell me if I’m misunderstanding.


28 posted on 07/17/2014 7:06:49 AM PDT by butterdezillion (Note to self : put this between arrow keys: img src=""/)
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To: Jenny217

My dad’s side of the family had to deal with this one generation after another.


29 posted on 07/17/2014 7:06:54 AM PDT by Eric in the Ozarks (Rip it out by the roots.)
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To: Patriot Babe
I wonder when can this injection be utilized to the public.

As soon as the FDA approves it.

Usually only takes fifteen or twenty years.

30 posted on 07/17/2014 7:10:23 AM PDT by E. Pluribus Unum ("The man who damns money obtained it dishonorably; the man who respects it earned it." --Ayn Rand)
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To: Innovative

It is a major event; however, I hope Smiling Bob is not involved in any way.


31 posted on 07/17/2014 7:15:12 AM PDT by SgtHooper (This is not my tag!)
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To: null and void

Much appreciate the ping


32 posted on 07/17/2014 7:23:27 AM PDT by Alex Murphy ("the defacto Leader of the FR Calvinist Protestant Brigades")
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To: Innovative

A single injection of FGF1 is not going to cure diabetes in humans. A thousand injections of FGF1 are not going to cure diabetes in a human. Diabetic humans are not the same creatures as rodent diabetic knock-outs.


33 posted on 07/17/2014 7:34:01 AM PDT by kruss3
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To: Innovative

Or you can just go to the health food store or online and buy Alpiste (Canary Seed) and mix with water and drink twice daily. Totally organic, no side effects, high protein, flushes fat and lowers blood sugar naturally. We drink it everyday.


34 posted on 07/17/2014 7:42:57 AM PDT by Georgia Girl 2 (The only purpose o f a pistol is to fight your way back to the rifle you should never have dropped.)
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To: Georgia Girl 2

Does the seed stay whole or do you grind it up first?


35 posted on 07/17/2014 8:01:26 AM PDT by moose07 (the truth will out ,one day.)
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To: moose07

Well you can buy the seeds then there is a process of soaking and grinding which is pretty simplistic or you can just buy the powder which is already prepared and mix it with water. Either one is about as effective as far as I can tell. We do both.

A lot of people who start drinking the canary seed milk get off the Type II Diabetes drungs after a few months. We have lost a good deal of weight already.


36 posted on 07/17/2014 8:12:30 AM PDT by Georgia Girl 2 (The only purpose o f a pistol is to fight your way back to the rifle you should never have dropped.)
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To: Georgia Girl 2

Great,
Thank you, will give this a go. :)


37 posted on 07/17/2014 8:17:15 AM PDT by moose07 (the truth will out ,one day.)
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To: moose07

Just google canary seed milk online and you can read all about it.


38 posted on 07/17/2014 8:24:01 AM PDT by Georgia Girl 2 (The only purpose o f a pistol is to fight your way back to the rifle you should never have dropped.)
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To: txrefugee

No such thing as Big Pharma. If one company can bring a drug that will run its competitors out of the market they will. If another company can make something similar, they will claim their version is superior and try to take all the business from the first company.

No different than Big Electronics or Big Deodorent.


39 posted on 07/17/2014 8:28:35 AM PDT by dangerdoc ((this space for rent))
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To: dangerdoc
No different than Big Electronics or Big Deodorent [sic].

Big Electronics is always coming up with shocking current innovations that charge the economy, but Big Deodorant is just the pits.

40 posted on 07/17/2014 8:36:15 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: dangerdoc
No such thing as Big Pharma. If one company can bring a drug that will run its competitors out of the market they will. If another company can make something similar, they will claim their version is superior and try to take all the business from the first company.

You incorrectly assume each Pharma has control over their product availability. The FDA is in control, and the FDA has a long record of burying good products. The really big Pharma control the FDA.

Unfortunately, scientists have cures for many problems in mice. In 2008, there was a Canadian study which found the following:

Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas. "I couldn't believe it," said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. "Mice with diabetes suddenly didn't have diabetes any more."

They injected the neuropeptide "substance P" in the pancreases of diabetic mice, a demanding task given the tiny size of the rodent organs. The results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection.

41 posted on 07/17/2014 9:06:38 AM PDT by aimhigh (1 John 3:23)
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To: aimhigh

I agree, the FDA moves too slowly. But on the other hand, they have cured about every disease known to man in mice and rat models. Those same treatments frequently are ineffective when tried on humans.


42 posted on 07/17/2014 9:19:49 AM PDT by dangerdoc ((this space for rent))
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To: Innovative

Won’t be of much use as high fructose corn syrup is in nearly everything.


43 posted on 07/17/2014 9:41:58 AM PDT by minnesota_bound
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To: Innovative

bfl


44 posted on 07/17/2014 10:02:59 AM PDT by AllAmericanGirl44
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To: FatherofFive

“Type 2 diabetes is completly preventable and completly treatable with diet and exercise.”

No.


45 posted on 07/17/2014 10:30:55 AM PDT by dsc (Any attempt to move a government to the left is a crime against humanity.)
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To: null and void

This is good news!



BE A DEAR AND
SEND MONEY HERE!


46 posted on 07/17/2014 10:31:10 AM PDT by Lady Jag (Tolerance and apathy are the last virtues of a dying society. - Aristotle)
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To: Jenny217

” But don’t argue with the holier than thou. It’s always a lifestyle choice according to them.”

It’s a religion with some people, and they are incapable—intellectually and emotionally—of accepting that obesity might be a matter of lipid regulation rather than moral turpitude.

The Church of the Immoral Fatso keens incessantly like a grieving banshee that every fat deposit is punishment for the loathsome perversion of over-eating, than which no sin is greater. Every fatso is guilty! Every fatso must be punished! All scientific findings to the contrary must be treated like leftists treat liberty!

It’s really not that hard to see the problem with the “calories in/calories out” nonsense. If not for the bigotry of the Church of the Immoral Fatso, science would be free to acknowledge the truth.

If normal people maintain a normal weight on a normal diet, and the vast majority did until recent decades, then why do some people become obese on a normal diet? The Church of the Immoral Fatso, of course, insists that all such reports are lies, and that the immoral fatsos were secretly over-eating. All scientific evidence to the contrary—and there’s a bunch—is simply denied.


47 posted on 07/17/2014 10:39:02 AM PDT by dsc (Any attempt to move a government to the left is a crime against humanity.)
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To: minnesota_bound

“Won’t be of much use as high fructose corn syrup is in nearly everything.”

Take a page from the leftard handbook: get a federal judge to ban it.


48 posted on 07/17/2014 10:40:45 AM PDT by dsc (Any attempt to move a government to the left is a crime against humanity.)
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To: Innovative

“It doesn’t look like they are restricting who can purchase it and it’s not even very expensive, given that one dose could provide full cure.”

The article says one dose was effective for up to four weeks.


49 posted on 07/17/2014 10:44:41 AM PDT by dsc (Any attempt to move a government to the left is a crime against humanity.)
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To: E. Pluribus Unum

Ain’t it the truth... Possible cures for cancer, Alzheimers, diabetes etc. Don’t want to rush them to market. Might prove harmful to terminally ill patients. /s


50 posted on 07/17/2014 10:59:22 AM PDT by daler
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