Right after 9/11 the Bellagio was screening every Car going into their Parking Garage. They screened mine.
The Protocol will apply to Luggage. Very easy to wand a Bag, either at the entrance or by the Elevator Lobbies without causing too much trouble.
I think the Hotel Guests would be just fine with it.
Very easy to wand it, but you will generate false positives like crazy. And what do you once the wands beeps? Go through people's bags by hands? That would never work, you'd need to then run it through an x-ray. It is a non-starter.