Posted on 10/13/2020 11:54:43 AM PDT by SeekAndFind
Hydroxychloroquine is ineffective and unsafe in the treatment of COVID-19: This is the belief held by millions of Americans and many healthcare professionals. After months of randomized clinical trials yielding findings that were not statistically significant, and others reporting side effects, no one could be blamed for reaching this conclusion.
But an important slice of the hydroxychloroquine data tells a different story.
Because of the medication’s politicization, and the pernicious tendency for dissenting perspectives to be silenced during the pandemic, data supporting hydroxychloroquine’s effectiveness have been almost inaudible. But a recent analysis pooling together results of randomized clinical trials testing hydroxychloroquine’s use in early COVID-19 infection should substantially raise the volume.
The hydroxychloroquine saga cannot be fully appreciated without first considering the unusual circumstances under which it arose. While the medical profession has always sustained debate over which treatments are best, the tenor of the hydroxychloroquine controversy is unique. Physicians who have advocated for its effectiveness have remained steadfast in their support of the medication, despite unsupportive clinical trials enrolling hospitalized patients, social media blackouts of their opinions, and a chorus of politicians and health officials telling them — and the country — that they’re not only wrong but reckless.
While physicians who hold marginalized or unpopular positions about treatments are often considered by peers to be motivated by profit or other self-serving interests, these physicians were unnoteworthy in that regard, and would largely have been considered “mainstream” prior to the pandemic. Their clinical experiences were dismissed as anecdotal, but consistently achieving patient outcomes that were markedly better than those reported around the country fueled their confidence and tenacity. The nation and the world may now benefit from their steadfastness.
(Excerpt) Read more at nydailynews.com ...
ABOUT THE AUTHORS OF THIS ARTICLE:
Ladapo, M.D., Ph.D., is associate professor of medicine at David Geffen School of Medicine at UCLA. Risch, M.D., Ph.D., is professor of epidemiology at Yale School of Public Health.
Ping as per your request
Basically. If we want a cure or worthy treatment to be used we just can’t have Trump promote it. Simple!
We had better start taking these types of treatments seriously. We will have another pandemic, let’s actually do some preparation this time around. Unlike nothing from Obama/Biden
MORE HERE:
https://www.medrxiv.org/content/10.1101/2020.09.30.20204693v1
Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis
By Joseph A. Ladapo, John E. McKinnon, Peter A. McCullough, View ORCID ProfileHarvey Risch
ABSTRACT:
Objective—To determine if hydroxychloroquine (HCQ) reduces the incidence of new illness, hospitalization or death among outpatients at risk for or infected with SARS-CoV-2 (COVID-19).
Design—Systematic review and meta-analysis of randomized clinical trials. Data sources—Search of MEDLINE, EMBASE, PubMed, medRxiv, PROSPERO, and the Cochrane Central Register of Controlled Trials. Also review of reference lists from recent meta-analyses.
Study selection—Randomized clinical trials in which participants were treated with HCQ or placebo/standard-of-care for pre-exposure prophylaxis, post-exposure prophylaxis, or outpatient therapy for COVID-19.
Methods—Two investigators independently extracted data on trial design and outcomes. Medication side effects and adverse reactions were also assessed. The primary outcome was COVID-19 hospitalization or death. When unavailable, new COVID-19 infection was used. We calculated random effects meta-analysis according to the method of DerSimonian and Laird. Heterogeneity between the studies was evaluated by calculation of Cochran Q and I2 parameters. An Egger funnel plot was drawn to investigate publication bias. We also calculated the fixed effects meta-analysis summary of the five studies. All calculations were done in Excel, and results were considered to be statistically significant at a two-sided threshold of P=.05.
Results—Five randomized controlled clinical trials enrolling 5,577 patients were included. HCQ was associated with a 24% reduction in COVID-19 infection, hospitalization or death, P=.025 (RR, 0.76 [95% CI, 0.59 to 0.97]). No serious adverse cardiac events were reported. The most common side effects were gastrointestinal. Conclusion—Hydroxychloroquine use in outpatients reduces the incidence of the composite outcome of COVID-19 infection, hospitalization, and death. Serious adverse events were not reported and cardiac arrhythmia was rare. Systematic review registration—This review was not registered.
Hydroxy *and zinc*.
I notice Trump was, along with whatever else he was treated with, given zinc and D.
First the NY Times claiming the pandemic will be over sooner than expected (link below) thanks to President Trump’s efforts and now this...what’s going on??
http://www.freerepublic.com/focus/f-news/3893363/posts
Thanks for the ping.
Bottom line...
#HCQWorksFauciKnew
Cheaper than a bottle of good wine.
And it has to cost $3000 a dose. HCQ is like 50 cents and could have been made OTC or absolutely free to everyone in the US.
HCQ was a known cure to covid long before it even hit our shores. This was covered up by truly evil people for purely political reasons.
This is absolutely correct
I applaud your work on this whole subject. The fact is it is a reasonable drug in early stage. It is not a cure. I still think it’s a good prophylaxis. But once to moderate or late phase. Not so good
Ha! I heard Rush talking about that NY Slimes article today. He says it must be due to poling hurting biden somehow.
And don't forget that Big Pharma doesn't make any $$$ off of Hydroxychloroquine.
I think the Dems and Media are getting ready to flip the narrative and blame all of the economic damage on President Trump for going along with the lock downs. I remember at least twice when POTUS said “I shut down the economy” and I think they will play these sound bites heavily in the closing days of the campaign. I’m not saying that it is his fault, I’m saying that THEY will say that it is his fault.
EXACTLY....my 94 yr old MIL currently in hospital with Covid is being given dexemethisone (sp) and remdisivir...NOT HCQ.
TDS Kills!
Something is sure going on when the WHO, NYSlimes and the NY Daily News have some positive things to say on the pandemic and ways to treat/coexist with it.
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