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Let’s all be honest about Hydroxychloroquine for Covid-19: Evidence is more positive than many in the medical community admit
The New York Daily News ^ | 10/13/2020 | By DR. JOSEPH A. LADAPO and DR. HARVEY A. RISCH

Posted on 10/13/2020 11:54:43 AM PDT by SeekAndFind

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To: goodnesswins

RE: EXACTLY....my 94 yr old MIL currently in hospital with Covid is being given dexemethisone (sp) and remdisivir...NOT HCQ.

HCQ is intended to be given during the first 5 to 6 days after a confirmed positive test, when early symptoms have started to manifest. The intent is to PREVENT hospitalization.

After a patient is serious enough to need hospitalization, HCQ’s effectiveness is mixed.


21 posted on 10/13/2020 12:54:48 PM PDT by SeekAndFind
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To: goodnesswins

The real failure in adopting HCQ + Zinc as a therapeutic treatment in the US was relying on a centralized bureaucracy (CDC, FDA) to determine its effectivity top-down rather than on a bottom-up analysis based on complex systems theory.

In bottom-up approaches medical practitioners are able to explore a wide range potential treatments for a disease on a small number of participants to reduce risk. The use of HCQ + Zinc was actually recommended by the NIH as a therapy for earlier SARS-2 epidemics and it was this literature that lead Dr. Vladimir Zelenko to experiment with it on his patients. If he had not seen any benefit he would have simply discontinued prescribing it and no one would ever heard of him just as biological solutions that fail die off from natural selection.

Because he found success he told other doctors and their experience spread word of mouth to demonstrate its safety and effectiveness without the need for the RCT formality. This uses parallel search in real time to solve a medical problem which is a much more adaptively efficient strategy when dealing with complex systems.


22 posted on 10/13/2020 12:57:50 PM PDT by Dave Wright
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To: SeekAndFind
No serious adverse cardiac events were reported.

Any doctor worth their pay will know his patient or will inquire about known heart issues.

23 posted on 10/13/2020 1:15:08 PM PDT by SKI NOW
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To: SeekAndFind

Hhmmm...well...she really isn’t seriously ill....from what they are telling us...other than issues she’s already had with congestive heart...Not one person in her Asst Living place has tested positive, and she has not been out since last year.


24 posted on 10/13/2020 1:24:59 PM PDT by goodnesswins (The issue is never the issue. The issue is always the revolution." -- Saul Alinksy)
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To: goodnesswins

I know of a 90 year-old woman who was on a ventilator at a hospital that is part of the largest medical system in Houston. They told her family that there was nothing else they could do for her.

The family ordered an ambulance to take her to the MD Anderson emergency room where she was treated with the hydroxychloriquine cocktail.

She made a full recovery. HCQ works, even at late stages of treatment.


25 posted on 10/13/2020 1:25:21 PM PDT by WASCWatch
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To: Dave Wright

What is irksome is that hydroxychloroquine is an FDA approved drug. Every physician has the legal jurisdiction to prescribe it for their patients. That some states and other government agencies temporarily banned its use is borderline criminal treason. TDS by these vile cretins of the left caused more deaths than was necessary and they have the gall to blame Trump. I can’t express my feelings in words on these posts.


26 posted on 10/13/2020 1:28:09 PM PDT by tflabo (Truth or tyranny)
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To: SeekAndFind

It’s a sad bleepin’ day in The United States of America, when patients’ health and even life & death decisions can be held hostage by strutting, snivelling prima donas, sticking their noses in the air and vetoing the using of well-known efficacious drugs, because of hatred, political loathing or satanic envy toward another American of a different party. It’s good I don’t rule the world. A number of stuffed shirt posers more interested in politics than in mercy and healing would find themselves receiving the precise treatment the have deigned to dump on the real people. Are you listening Fauci? Birx? Redfield? WHO? CDC? You’ve been skating for decades. But when you find yourself before the Supreme Judge of the Universe, the skates come off. We’ll see how well you skate barefoot.....on fire and brimstone. Payday is coming!


27 posted on 10/13/2020 1:35:40 PM PDT by Tucker39 ("It is impossible so to rightly govern a nation without God and the Bible." George Washington)
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To: SeekAndFind

Our doctors told us the new guidelines are there are no treatments for covid. If you have a hard time breathing, go to the ER. The state of our healthcare system, thanks to the democrats.


28 posted on 10/13/2020 1:41:06 PM PDT by Trillian
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To: SeekAndFind

Treatment protocol

Prophylaxis

Zinc (50mg to 100mg per day)
Quercetin (500mg to 1000mg per day)
Bromhexine (25mg to 50mg per day)
Vitamins C (1000mg) and D (2000 u/d)

Early treatment

Zinc (75mg to 150mg per day)
Quercetin (500mg to 1500mg per day)
Bromhexine (50mg to 75mg per day)
Vitamins C (1000mg) and D (4000 u/d)
Aspirin (162mg to 325mg per day)

Ancillary (prescription only)

Hydroxychloroquine (400mg per day)
High-dose vitamin D (1x 100,000 IU)
Azithromycin (up to 500mg per day)
LMW heparin (usual dosage)

Note: Contraindications for HCQ (e.g. favism or heart disease) must be observed. However, a study by the European Heart Rhythm Association (EHRA) confirmed that correctly dosed HCQ is safe for covid patients in any clinical setting.

Addendum: Other prescription drugs with first reported successes in the early medical treatment of Covid-19 are ivermectin (read more) and favipiravir (read more).
Treatment successes

For more results, see the full scientific references at the bottom of this page.

Zinc/HCQ/AZ

A Spanish study found that low plasma zinc levels (below 50mcg/dl) increased the risk of in-hospital death of covid patients by 130%.
US physicians reported an 84% decrease in hospitalizations, a 50% decrease in mortality among already hospitalized patients (if treated early), and an improvement in the condition of patients within 8 to 12 hours based on Zinc/HCQ/AZ early treatment.
Italian hospital doctors reported a decrease in deaths of 66% based on HCQ treatment.
US physicians moreover reported a 45% reduction in mortality of hospitalized patients by adding zinc to HCQ and azithromycin.
Another US study reported a rapid resolution (within hours) of Covid symptoms, such as shortness of breath, based on early outpatient treatment with high-dose zinc.
A Dutch study on HCQ published in the International Journal of Infectious Diseases found a 53% risk reduction in terms of ICU admission and ventilation of covid patients.
Australian Professor Thomas Borody reported an improvement in the condition of covid patients often within hours after treatment with zinc, ivermectin and azithromycin.
See also: An overview of more than 100 international HCQ studies.

Bromhexine

Iranian doctors reported in a study with 78 patients a decrease in intensive care treatments of 82%, a decrease in intubations of 89%, and a decrease in deaths of 100%.
Chinese doctors reported a 50% reduction in intubations due to bromhexine treatment.
A German study discusses the efficacy of bromhexine based on biochemical properties.

Vitamin D

In a Spanish randomized controlled trial (RCT), high-dose vitamine D (100,000 IU) reduced the risk of requiring intensive care by 96%.
A large Israeli study found a strong link between vitamin D deficiency and covid-19 severity.
A 2017 meta-study found a positive effect of vitamin D on respiratory tract infections.

Aspirin

A US study showed that aspirin has a strong antiplatelet and anticoagulant effect in Covid patients, which could help prevent infection-related thrombosis, embolism and stroke.

Modes of action

Zinc inhibits RNA polymerase activity of coronaviruses and thus blocks virus replication, as first discovered by world-leading SARS virologist Ralph Baric in 2010.
Hydroxychloroquine and quercetin support the cellular absorption of zinc and have additional anti-viral properties, as first discovered during the SARS-1 epidemic in 2003.
Bromhexine, a mucolytic cough medication, inhibits the expression of cellular TMPRSS2 protease and thus the entry of the virus into the cell, as first described in 2017.
Vitamins C and D improve the immune system response.
Azithromycin (an antibiotic) prevents bacterial superinfections of the lung.
Aspirin may prevent infection-related thrombosis and embolisms in patients at risk.

See also: An illustration of the mechanisms of action of HCQ, quercetin and bromhexine
Additional notes

The early treatment of patients as soon as the first typical symptoms appear and even without a PCR test is essential to prevent progression of the disease. Zinc, HCQ, quercetin and bromhexin may also be used prophylactically for people at high risk or high exposure (e.g. for health care workers).

In contrast, isolating infected high-risk patients at home and without early treatment until they develop serious respiratory problems, as often happened during lockdowns, may be detrimental.

The alleged or actual negative results with hydroxychloroquine in some studies were based on delayed use (intensive care patients), excessive doses (up to 2400mg per day), manipulated data sets (the Surgisphere scandal), or ignored contraindications (e.g., favism or heart disease).

Early treatment based on the above protocol is intended to avoid hospitalization. If hospitalization nevertheless becomes necessary, experienced ICU doctors recommend avoiding invasive ventilation (intubation) whenever possible and using oxygen therapy (HFNC) instead.

It is conceivable that the above treatment protocol, which is simple, safe and inexpensive, could render more complex medications, vaccinations, and other measures largely obsolete.

swprs.org


29 posted on 10/13/2020 1:47:57 PM PDT by eyeamok
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To: SeekAndFind
How many died because of the OrangeDrugBad publicity and the trials that used HCQ+AZ only as a last resort?

Politicized science with a body count.

30 posted on 10/13/2020 1:50:46 PM PDT by TChad (The MSM, having nuked its own credibility, is now bombing the rubble.)
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To: SeekAndFind

I have been on this drug for years now treating a condition that I have. If it is working to keep Covit away from me, good. Because I have not had any issues with Covit. And I have been around people who had it, not that I knew that when I was around them, found out later they had it. One person in our church had it, but NO ONE ELSE got it from that person!!! NO ONE!!! And I am sure that I was probably the only one on this drug because no one else admitted it and I did tell some in our Sunday School class that I was on it. So, maybe it is working to protect me. Who really ever knows how some drug will work for you or not. It is just the odds of the drug working for you or not, but that is all drugs we take. Otherwise, they would not put that 9-mile long list of bad things that happen to people taking it!!


31 posted on 10/13/2020 1:52:50 PM PDT by RetiredArmy (Friends, are you prepared to meet the LORD? Do you KNOW Him? Time is running out.)
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To: 1Old Pro

The fall is early. Winter is coming. I FULLY expect another CRY and CLAIM that the virus has returned and the whole world needs to be locked down again. I saw on TV this a.m. where England has a three-tier lock down starting up. Hell, just do what Sweden did, do nothing, go on with life and it seemed to work for them. We got infested by all those who went to China and returned with it, plus the Chinese who came here and spread it around.


32 posted on 10/13/2020 1:55:13 PM PDT by RetiredArmy (Friends, are you prepared to meet the LORD? Do you KNOW Him? Time is running out.)
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To: RetiredArmy

We got infested by all those who went to China and returned with it, plus the Chinese who came here and spread it around.

I thought Trump shut off flights from China as early as January.

33 posted on 10/13/2020 2:06:01 PM PDT by FormerFRLurker (Keep calm and vote your conscience.)
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To: SeekAndFind

Thanks for the graphs.


34 posted on 10/13/2020 2:07:06 PM PDT by FormerFRLurker (Keep calm and vote your conscience.)
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To: marron

I notice Trump was, along with whatever else he was treated with, given zinc and D.

I wonder why Trump was not given HCQ. I'm sure he asked for it and AFAIK he doesn't have a heart condition that would HCQ dangerous for him. The zinc and D would have helped though.

35 posted on 10/13/2020 2:09:01 PM PDT by FormerFRLurker (Keep calm and vote your conscience.)
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To: SeekAndFind

It would be dangerous for me to take HCQ because of a congenital heart condition running in my family that I might have inherited. However, for the majority of people it is a safe drug when taken as directed by a doctor. And as gas_dr says, it is best administered in the early stages of COVID.


36 posted on 10/13/2020 2:11:55 PM PDT by FormerFRLurker (Keep calm and vote your conscience.)
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To: FormerFRLurker

Yeah, but they still flew into Canada and Mexico and Europe and came here. The Chinese probably started infesting us with the China Virus way before we even knew it was coming. The Gates, Soros, Foul-chy mob had that conference way back in the fall of 2019 re: a Corona virus and damned if five months later, we had one. AND, the Foul-chy and Marxist’s in the country said it WAS OKAY TO MIX AND MINGLE, EVEN IN CHINA TOWN in NYC and Homofrisco, where it probably was festering and only needed people to take it out and spread it in their neighborhoods!!!


37 posted on 10/13/2020 2:13:08 PM PDT by RetiredArmy (Friends, are you prepared to meet the LORD? Do you KNOW Him? Time is running out.)
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To: FormerFRLurker

Somewhere early in the first family’s treatment, I read that the First Lady was receiving hydroxychloroquine, but have not been able to confirm it.

Did anyone else see it and could they confirm?


38 posted on 10/13/2020 2:41:38 PM PDT by chronicles
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To: eyeamok

Thanks for posting that (again). It doesn’t matter how many times I’ve seen it. It is nice to have a refresher on the protocols out there should I ever need them.


39 posted on 10/13/2020 2:48:42 PM PDT by FamiliarFace
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To: SeekAndFind

I have a friend who recently died 10 days after a positive covid test, and they did NOTHING for him. After the test he languished for a week in the care center, then got pneumonia so bad he went to the emergency room, then went back to the care center and died. I can’t believe they did absolutely nothing.

CDC does not recommend any early intervention. There is blood on the hands of the feral media and feral democrats who blacklisted early intervention like HCQ.


40 posted on 10/13/2020 3:00:29 PM PDT by dynoman (Objectivity is the essence of intelligence. - Marilyn vos Savant)
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