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Cause of Mystery Disease Believed Found (Coronavirus)
AP Online via COMTEX ^ | Mar 24, 2003 | DIRK BEVERIDGE

Posted on 03/24/2003 12:24:11 PM PST by grimalkin

HONG KONG, Mar 24, 2003 (AP Online via COMTEX) -- A mystery disease spread new fears across Asia on Monday as Singapore quarantined hundreds of people, and Hong Kong and Vietnam reported more deaths amid closed schools and growing fear.

At the same time, scientists in Geneva and the United States said they believe the cause of the flu-like ailment that has stymied them for weeks could be one of the viruses that causes the common cold.

The U.S. Centers for Disease Control and Prevention said Monday that evidence is mounting the cause is a coronavirus, a bug that can cause colds.

CDC director Dr. Julie Gerberding in Atlanta said a form of the virus unlike any seen in humans before has been found in the lungs and other tissue of some victims.

Furthermore, patients seem to develop antibodies to the virus as they get sicker with the pneumonia, Gerberding said.

There is no known treatment, although the World Health Organization said last week it had developed a reasonable test for diagnosing the disease. CDC scientists are skeptical of its accuracy.

The illness, called severe acute respiratory syndrome, SARS, has produced 456 cases and 17 deaths since Feb. 1, WHO says. Those figures do not include cases and deaths from mainland China where the disease is believed to have begun in November.

Hong Kong accounts for more than half the reported cases around the world, with 260, and 10 deaths, two of those reported Monday. Vietnam also reported two new deaths Monday, just two days after the U.S. State Department advised citizens to avoid travel to the country because its hospitals are in crisis.

The WHO also reported another death in Canada, bringing that country's total to three. There have been no deaths in the United States.

In the meantime, Hong Kong government officials met to draw up health guidelines for everything from restaurants to bus systems in an attempt to slow the spread of the flu-like illness. And the territory's health secretary, Dr. Yeoh Eng-kiong, called it "a really very alarming disease," the likes of which Hong Kong has never seen.

On Sunday, the news that Hong Kong's health chief was hospitalized with the respiratory symptoms indicative of the disease merely added to the anxiety.

"I think it's spreading very quickly," said Lisa Fung, a masked 44-year-old worker at a domestic help recruitment agency. "Even William Ho has got it and he hasn't had to go treat the patients."

It was not known immediately if Ho was sick with SARS, which has symptoms of a fever of at least 100.4, combined with coughing, shortness of breath or difficulty breathing. But Hong Kong officials noted he had been going through hospitals to offer moral support to front-line medical workers and patients.

Health authorities suspect SARS is linked with an earlier atypical pneumonia outbreak in mainland China's Guangdong province that killed five people and sickened 305. A WHO team that arrived over the weekend in Beijing said Monday it was analyzing the Chinese cases in the scramble to unravel the disease.

For days, Hong Kong officials had said that SARS did not threaten the community at large, but Yeoh issued new warnings on Monday, urging people with flu-like symptoms to stay away from work and school.

"The situation now is very difficult," he said.

Government officials were planning guidelines for hospitals, schools, transport systems, public housing and restaurants. Four schools were closed temporarily, after seven students, a teacher and a bus driver were infected, although their cases were linked to sick relatives.

Singapore's efforts to contain the disease came as Health Minister Lim Hng Kiang announced he was invoking the Infectious Diseases Act for what could be the first time since the city-state gained independence in 1965.

Over the weekend, Singapore said it would empty one of its main hospitals and dedicate it to coping with the disease.

The health minister said authorities had ordered about 740 people who may have been exposed to victims of the illness to stay home for 10 days and have no contact with others. Any quarantined person caught outside his home could face a fine of up to $2,825.

In Hong Kong, many residents wore surgical masks around the city, hoping to avoid infection.

Officials offered some encouragement, saying that many of the sick seemed to improve with steroids and an anti-viral drug, ribavirin. Some of the sickest Hong Kong patients were receiving injections of antibodies obtained from victims who have recovered and their initial responses appeared good, Yeoh said.

WHO scientists said they still had not ruled out the possible cause of paramyxovirus, which causes measles, mumps and canine distemper.

"We now have two major (virus) groups and it's up to the laboratories to see where the virus is going to end up," said Dr. Klaus Stohr, a WHO virologist who is coordinating the work of WHO's network of 11 labs.

By DIRK BEVERIDGE Associated Press Writer


TOPICS: Culture/Society; Extended News
KEYWORDS: cdc; coronavirus; hongkong; infectiousdisease; paramyxovirus; pneumonia; sars; singapore; vietnam; who
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To: Geezerette
My dog has had annual corona/distemper/parvo shots each year for the past ten years ... she's 12. A Pomeranian

Just in case you're not aware of the latest vaccination protocols----

Twenty-two Schools of Veterinary Medicine including Texas A&M University do not recommend canine corona virus vaccine. Apparently, they've (A&M) seen only 1 case in the last 7 yrs.

41 posted on 03/24/2003 1:36:30 PM PST by Solon
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To: grimalkin; Mother Abigail; CathyRyan
CDC Press Release.
42 posted on 03/24/2003 2:12:17 PM PST by aristeides
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To: All
New AP story incorporates CDC input: Cold-Causing Bug Suspected in Mystery Flu.
43 posted on 03/24/2003 2:16:38 PM PST by aristeides
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To: Solon
Thanks!!! Several months ago, there was a thread here on FR with the source as the Houston Chronicle. It stated that vets are now finding out that dogs should not have those 3 in 1 shots every year ... maybe every two or three years. Rabies every three years.

My dog was due for her rabies AND the other shots this month, and keeping that article in mind, just had her get the rabies shot only to satisfy the license law. So, really, she hasn't had those other shots in a little over a year.

I was going to wait a year or more to have her vaccinated ... she is an eight-lb. dog, and that article said that the little ones get the SAME dose as a St. Bernard would get!!!

So, maybe she doesn't need them anymore??

Again, thanks for any info!

g

44 posted on 03/24/2003 2:42:20 PM PST by Geezerette (... but young at heart!)
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To: aristeides
"...By inhalation of aerosols..."

I wonder when the CDC will be honest with us and tell us the real history of this and West Nile...
45 posted on 03/24/2003 2:55:19 PM PST by Terridan (God, help us deliver these Islamic savage animals BACK into hell where they belong...)
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To: Terridan; Mother Abigail; CathyRyan
Suspected U.S. SARS Cases Now 39 .
46 posted on 03/24/2003 3:12:05 PM PST by aristeides
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To: aristeides
Uh oh. Does this mean it spreads as easily as the common cold?

I'm not sure how it could be otherwise. The hospital workers who contracted the illness were not kissing their patients.

47 posted on 03/24/2003 4:05:03 PM PST by Dog Gone
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To: aristeides
Thanks for the info... scary huh? I didn't see mentioned though, the names of the infected kids in Michigan, or Chicago was it? They died... ages 2 - 8. No mention whatsoever. It was unusual because kids at that age not suseptible to death as infants or the elderly. I am still suspicious, as I am about West Nile, and its quickened spread across the US. It didn't follow the usual progression of spreading, after arriving here. Who knows. Invisible killers, but I think Islam related. God Bless!
48 posted on 03/24/2003 7:31:47 PM PST by Terridan (God, help us deliver these Islamic savage animals BACK into hell where they belong...)
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To: Terridan
Teenagers and young adults are said to have had the highest mortality from the Spanish flu in 1918-9.
49 posted on 03/24/2003 7:40:36 PM PST by aristeides
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To: grimalkin; aristeides; vetvetdoug; bonesmccoy
We are making progress on the diagnostic front. Hong Kong radiologists have determined that chest X-rays of SARS patients show unique characteristics. They have been producing reliable results, using this crude method, since Saturday. They are quite confident that this form of analysis separates probable cases from suspect cases effectively. Clearly it is critical not to expose patients ill with something else to SARS.
50 posted on 03/25/2003 4:56:42 AM PST by TaxRelief (Pray for our troops...)
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To: aristeides; Mother Abigail
Such a lab doesn't have to be in or near China or Hong Kong, of course.

"Facteurs de virulence des coronavirus hemagglutinants et valeur vaccinale et diagnostique des protéines recombinantes"

translation:
"Factors of virulence of the coronavirus hemagglutinants and vaccine value and diagnoses recombining proteins", was published just a couple of years ago out of the University of Quebec, microbiology and biotechnology.

==> A cure for the common cold? Or research to weaponize it?
51 posted on 03/25/2003 7:09:03 AM PST by LurkedLongEnough (Aaaaachew!)
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To: Mother Abigail
This kills our paramyxovirus theory. A coronavirus being the causative agent complicates things a lot since there are literally thousands of coronaviruses in the mammalian species. In cats it is extremely difficult to differentiate the pathogenic coronaviruses from the non-pathogens. There is so much cross reactivity with the tests that the one's that are available are questionable when just the test is positive without clinical symptoms. Hogs and cats have the most pathogenic. It is very questionable if the canine virus is really a pathogen or just a saphrophytic organism. I do not recommend the canine coronavirus vaccine.
52 posted on 03/25/2003 8:09:31 AM PST by vetvetdoug
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To: Mother Abigail
Easier said then done...my mother returned home from England last week, Manchester no less--not a whole lot you can do to avoid it.
53 posted on 03/25/2003 8:16:55 AM PST by glory
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To: Mother Abigail
ON a positive note, she's been home a week and only has her usual sinus problems with spring so that is past incubation time right so we are safe to assume she didn't pick anything up on her flight home?
54 posted on 03/25/2003 8:17:38 AM PST by glory
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To: vetvetdoug
But the head of Health Canada's national microbiology laboratory in Winnipeg said scientists there have been unable to replicate the CDC's findings working with specimens taken from Canadians who have developed severe acute respiratory syndrome.

"We've been aware of these (CDC) results for a couple days and as yet we've not been able to confirm the results," said scientific director Dr. Frank Plummer.

"Our results were negative for coronaviruses. And we continue to find evidence of human metapneumovirus."

On Friday, Plummer announced his team had found human metapneumovirus, a member of the paramyxovirus family, in specimens from six of eight patients for whom the lab had samples.




Seems to be a difference of opinion.

Very real possibility that both are finding artifacts...
55 posted on 03/25/2003 11:06:42 AM PST by Mother Abigail
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To: glory
A flight from England to US is not really a concern.

It is Asia, and stopovers in Asia that are bothersome...
56 posted on 03/25/2003 12:11:03 PM PST by Mother Abigail
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To: Mother Abigail
Are there any new textbooks on Virology that are current and reflect all of the taxonomic changes that have occurred since PCR technology?
57 posted on 03/25/2003 12:22:49 PM PST by vetvetdoug
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To: vetvetdoug
This is a unique situation that includes paramyxoviridae and coronoaviridae working in concert.
58 posted on 03/25/2003 1:15:45 PM PST by TaxRelief (Pray for our troops...)
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To: vetvetdoug
The Best
59 posted on 03/25/2003 1:44:15 PM PST by Mother Abigail
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To: TaxRelief
I was thinking that if this was the result of simultaneous infection with the two viruses, then killing or neutralizing either one could stop the disease. But your post gives me another thought: another line of attack would be to stop their working together in concert.
60 posted on 03/25/2003 1:55:26 PM PST by aristeides
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