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New approach will finally kill herpes
The Times of India ^ | 4 Jul 2008, 0254 hrs IST | REUTERS

Posted on 07/04/2008 9:57:35 AM PDT by CarrotAndStick

WASHINGTON: US researchers reported that they may have found a way to flush out herpes viruses from hiding — offering a potential way to cure pesky and painful conditions from cold sores to shingles.

They discovered that a mysterious gene carried by the herpes simplex-1 virus — the one that causes cold sores — allows the virus to lay low in the nerves it infects.

It does so via microRNAs, little pieces of genetic material that regulate the activity of many viruses, the researchers report in the journal Nature.

It may be possible to "wake up" the virus and then kill it with standard antiviral drugs such as acyclovir, said Jennifer Lin Umbach of Duke University in North Carolina, who worked on the study. "We are trying to go into animal trials," Umbach said.

The Duke team is discussing a potential collaboration with Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc and Isis Pharmaceuticals, Inc that specializes in microRNAs. Herpes viruses cause permanent infections. They head straight to nerve cells, where they stay latent for the life of an animal or person, often causing periodic outbreaks.

Herpes simplex 1 or HSV-1 causes cold sores, HSV-2 causes genital herpes, while varicella causes chicken pox and returns in middle or old age as herpes zoster to cause shingles.


TOPICS: News/Current Events; Technical
KEYWORDS: health; healthcare; herpes; medical; pathogen; virus
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To: donna
If you are talking about a herpes virus, you are talking about shingles.

/johnny

81 posted on 07/04/2008 3:18:04 PM PDT by JRandomFreeper (Bless us all, each, and every one.)
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To: Gondring; CarrotAndStick; Myrddin; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ...
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

http://learn.genetics.utah.edu/

Virtual Library on Genetics

Happy Fourth of July!!!

82 posted on 07/04/2008 3:18:10 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: JRandomFreeper
Herpes simplex 1 or HSV-1 causes cold sores, HSV-2 causes genital herpes, while varicella causes chicken pox and returns in middle or old age as herpes zoster to cause shingles.

From the article.

83 posted on 07/04/2008 3:21:32 PM PDT by donna (Sticks and stones may break my bones but words will never hurt me.)
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To: CarrotAndStick; neverdem; wagglebee; Mr. Silverback

“It may be possible to “wake up” the virus and then kill it with standard antiviral drugs”


If people would stop acting like random disease vectors, the viral marketing would stop and we’d be mostly rid of these ‘social’ diseases in one generation.


84 posted on 07/04/2008 3:27:12 PM PDT by The Spirit Of Allegiance (Public Employees: Honor Your Oaths! Defend the Constitution from Enemies--Foreign and Domestic!)
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To: Ditter
I had it in my eye and needed a corneal transplant to save some minimal vision. I now take acyclovir for life and have to wear a special contact in that eye.

I am wondering, based on the article, if acyclovir the way I take it actually cures herpes. I know they have only started to study this potential, but it would be great to find out that I am really OK. The dr. said it could come back at any time and cause a second transplant.

85 posted on 07/04/2008 4:12:13 PM PDT by EBH ( ... the riotousness of the crowd is always very close to madness. --Alculin c.735-804)
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To: donna

You’re like Rocky...only without the ability to punch.


86 posted on 07/04/2008 4:44:55 PM PDT by Bogey78O (Don't call them jihadis. Call them irhabis. Tick them off, don't entertain their delusion.)
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To: Bogey78O

What happened was I stirred up a nest of people who don’t want to be told that sex outside of marriage is wrong.


87 posted on 07/04/2008 4:52:31 PM PDT by donna (Sticks and stones may break my bones but words will never hurt me.)
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To: donna

Yeah, them cold sores are the direct result of sex...

Geez, some people don’t need any excuse to whine about people having sex...


88 posted on 07/04/2008 4:54:52 PM PDT by Lord_Baltar
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To: Lord_Baltar

I didn’t mention cold sores.


89 posted on 07/04/2008 4:56:51 PM PDT by donna (Sticks and stones may break my bones but words will never hurt me.)
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To: donna

No donna, but you didn’t bother to read the article, either.

Otherwise the 2nd post out of the gate, by you, wouldn’t have been the usual knee-jerk scold about sex.


90 posted on 07/04/2008 5:02:46 PM PDT by Lord_Baltar
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To: EBH

OMG! How awful for you. My husband has a big irregular red scar on his back that still itches after 6 months and may itch forever but that is still better than the eye. The man I mentioned who I said had it in his eye may have just have had it around his head and face, not his eye, now that I think about it. The woman I know who DID have it in her eye is blind in that eye. It will be wonderful if this new treatment works. My husband is 73 and his shingles hit him a couple of months after he had a double by pass. WE had not heard about the shingles vaccine until after he came down with it.


91 posted on 07/04/2008 6:33:39 PM PDT by Ditter
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To: donna
Why pretend I said anything other than what I said?

Not pretending, we all know what the article said, It's what you said that has raised a ruckus. As you can see we all immeadiately saw what you were trying to say.

Why are you running from your inference? Be brave, stand up for what you were thinking at the time you 'penned' your first post.

92 posted on 07/04/2008 6:46:59 PM PDT by Balding_Eagle (OVERPRODUCTION......... one of the top five worries for American farmers.)
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To: Lord_Baltar
knee-jerk scold about sex

Yeah, we wouldn't want to scold anybody, LOL.

93 posted on 07/04/2008 6:55:51 PM PDT by donna (Sticks and stones may break my bones but words will never hurt me.)
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To: Balding_Eagle

Don’t have sex out of wedlock. I’ll stand by it.


94 posted on 07/04/2008 7:04:15 PM PDT by donna (Sticks and stones may break my bones but words will never hurt me.)
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To: donna

That isn’t what you said. I’m getting a good laugh out of you today.


95 posted on 07/04/2008 7:31:54 PM PDT by Balding_Eagle (OVERPRODUCTION......... one of the top five worries for American farmers.)
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To: Gondring

My God, is she really this stupid, or is it something hormonal?!


96 posted on 07/04/2008 7:39:32 PM PDT by DeLaine (I see dumb people. They're everywhere. They don't even know they're dumb.)
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To: MtnScout

Give it up. She’s determinedly obtuse.


97 posted on 07/04/2008 7:42:06 PM PDT by DeLaine (I see dumb people. They're everywhere. They don't even know they're dumb.)
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To: neverdem

Thanks for the links!


98 posted on 07/04/2008 7:44:26 PM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: Gondring; donna

Oh I’m supposed to ping Donna to tell her that I think her fixation on sexual transmission of non sexual diseases is stupid? ok. Here ya go Donna. Get over it already. You try so hard to sound learned and logical and you are failing miserably.


99 posted on 07/04/2008 7:45:01 PM PDT by DeLaine (I see dumb people. They're everywhere. They don't even know they're dumb.)
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To: CaliforniaCon; MarineMom613
So shall we compare the horrors of our shingles experiences?

You're scaring me! Thanks for the warnings!

100 posted on 07/04/2008 7:46:19 PM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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