The FedGov has the power to oversee the manufacture and distribution of any and all potentially toxic substances, including drugs - legal and illegal. My point about the other “crimes” was about debunking the notion that simple because there are people out there engaging in certain behaviors (criminal or otherwise) which are harmful does not mean that society should or wants to stop enforcing prohibitions against those crimes/behaviors. Is this really that difficult to figure out?
So, since water is toxic in the right quantities, government needs to regulate it?
They have power to control education, finance, health care, and a host of other issues as well, thanks to the Wickard Commerce Clause from the FDR era. Do you think that is in keeping with the clause's original meaning?