The skin disease that cures itself

Nature News ^ | 26 August 2010 | Ewen Callaway

[neverdem]

Diseased cells have harnessed a cancer-causing mechanism to banish a mutant gene.

Cells that can get the better of a rare skin disorder have helped scientists to explain the disease. Curiously, some patients' cells can eliminate the disease-causing mutation that underlies ichthyosis, and as a result have healthy patches of skin speckled all over their bodies.

By analysing the DNA in these areas and in affected ones, scientists have pinpointed the gene responsible for the disease, as well as the cellular mechanism responsible for its patchy disappearance1.

Ichthyosis is characterized by a breakdown in the structure of skin cells that leaves patients with thick, scaly layers of inflamed skin. In one form, known as ichthyosis with confetti (IWC), patients develop small patches of healthy skin that grow in number and size over time.

Dermatologists at Yale University School of Medicine in New Haven, Connecticut, initially identified two patients with the condition — too few to find a disease-causing mutation using traditional approaches.

But when one of the researchers, Keith Choate, mentioned the healthy patches to Yale geneticist Richard Lifton, Lifton had an idea. "Just looking at it, we thought, well, gosh — the genetics of this disease is caused by a dominant mutation and these spots represent revertants," or cells that had lost the mutation, he says.

Likely explanation Cells can undergo spontaneous mutations that 'fix' a disease-causing gene, but this process is too rare to have occurred in every healthy spot in patients with IWC. A likelier explanation, Lifton reasoned, was a process called mitotic recombination, whereby dividing maternal and paternal chromosomes exchange DNA. This process is linked to cancer because it can allow a once recessive cancer-causing mutation to suddenly take effect.

With this theory in mind, Lifton, Choate and their colleagues scoured the genomes of one patient's...

[neverdem]

Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10

[Lancey Howard]

(( ping ))
I think this may be down your alley.

[MARTIAL MONK]

The heartbreak of ichthyosis

[Vendome]

Makes my skin crawl.

Just don’t understand the scale of it all.

There should be some genetic patch. /s

[Scythian]

Thanks, I researched that. I am one of the few that has walked away from this plague. I did it all through natural products that are suprisingly “common”.

Part 1
http://morgellonspgpr.wordpress.com/2009/08/08/morgellons-the-poor-mans-protocol/

Part 2
http://morgellonspgpr.wordpress.com/2010/04/17/poor-mans-protocol-2-pmp-ii/

The body has an amazing ability to heal provided you give it what it needs.