[neverdem]

This discovery could lead to a drug that inhibits a part of this cell signaling pathway, thus restoring the insulin sensitivity in many, if not most, type II diabetics. I wouldn't hold my breath. If it pans out, it could take a number or years.

FReepmail me if you want on or off the diabetes ping list.

[darth]

The Life Extension Foundation funded a study to search for common drugs that activated some of the same genes activated by calorie restriction. Bingo! Metformin, a common anti-diabetes drug induces some of the same gene activation.

Have been on low-dose metformin for seven years now. I noticed that my body temp seems to be 1-2F low at all times and my metabolism has noticeably slowed. The life extension effect could be due simply to slower chemical processes in the body. Roy Walford found similar life extension in animals with lower body temps.

Still experimenting!

BTW, you can buy metformin from a European pharmacy from Anti-Aging Systems. Have been buying from them for decades.

See Life Extension Foundation’s website, www.lef.org, for journal articles, etc.