I thought it was pretty well known for decades that animal testing had serious limitations, could only be used for specific mapping, and that any results were uncertain until human trials were completed. What’s new about this “discovery”?
From the abstract: "Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent."
Mouse Models Fail to Reproduce Inflammatory Genomic Response to Serious Injuries
The press release linked above gives more particulars.
Part of the inflammatory response is the recruitment of cells of the innate immune system.
Now they have some insight into why billion dollar clinical trails were such spectacular flops. Fundamental assumptions about genetics and genomics in immunology and their differences between species were flawed. A lot of studies using rats and mice that had genes knocked out, i.e. deleted, can be called into question.