if they DO.
In Isaiah 17, Damascus the Capitol city of Syria is destroyed utterly in a day and no one ever lives there again. With current world events as a framework I would guess Assad looses to ISIS, they fire some of the Syrians vast chemical weapons stockpiles at Israel, and Israel nukes them.
To condense All of the chapter into one sentence, ‘In the evening there is trouble, by morning it’s over, Damascus is a ruined heap, and man will never live there again’.
It is also prophesied that Damascus becomes an Israeli border town in the future.