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'Off switch' for pain discovered: [...]
ScienceDaily ^ | 26 Nov 2014 | Saint Louis University Medical Center

Posted on 11/28/2014 7:07:17 AM PST by shove_it

In research published in the medical journal Brain, Saint Louis University researcher Daniela Salvemini, Ph.D. and colleagues within SLU, the National Institutes of Health (NIH) and other academic institutions have discovered a way to block a pain pathway in animal models of chronic neuropathic pain including pain caused by chemotherapeutic agents and bone cancer pain suggesting a promising new approach to pain relief.

The scientific efforts led by Salvemini, who is professor of pharmacological and physiological sciences at SLU, demonstrated that turning on a receptor in the brain and spinal cord counteracts chronic nerve pain in male and female rodents. Activating the A3 receptor -- either by its native chemical stimulator, the small molecule adenosine, or by powerful synthetic small molecule drugs invented at the NIH -- prevents or reverses pain that develops slowly from nerve damage without causing analgesic tolerance or intrinsic reward (unlike opioids)...

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Culture/Society; News/Current Events
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Full Headline: 'Off switch' for pain discovered: Activating the adenosine A3 receptor subtype is key to powerful pain relief
1 posted on 11/28/2014 7:07:17 AM PST by shove_it
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To: shove_it

Soon to be used on the battlefield to create zombie soldiers?


2 posted on 11/28/2014 7:08:21 AM PST by jsanders2001
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To: shove_it

NO Brain... NO Pain!!!


3 posted on 11/28/2014 7:10:23 AM PST by tired&retired
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To: shove_it

Nice. But isn’t this a little like putting a piece of electrical tape over your ‘check engine light’?


4 posted on 11/28/2014 7:18:29 AM PST by fhayek
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To: tired&retired

A lot of Michigan Medical Marijuana users claim the pot is for pain. One guy said his thumb hurt a lot and he couldn’t work. I told to stick his thumb in his ass and see if it helped. I really did. He was speechless.


5 posted on 11/28/2014 7:18:58 AM PST by healy61
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To: shove_it; FReepers

Good news for KenyanKare death panels.


6 posted on 11/28/2014 7:19:39 AM PST by shove_it (long ago Orwell and Rand warned us of Obama's America)
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To: shove_it

We can switch off Obama?


7 posted on 11/28/2014 7:21:14 AM PST by vladimir998
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To: fhayek

Maybe - but with some diseases there’s no need to check the engine. There’s no way to fix the engine.


8 posted on 11/28/2014 7:22:23 AM PST by ladyjane
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To: shove_it
This will be useful for me as I transform into the Metallic Robotic Warlord Zombie Soldier, for when I finally take over Earth.

I intend to replace my head with Richard Nixon's, too.


9 posted on 11/28/2014 7:23:27 AM PST by Lazamataz (Proudly Deciding Female Criminal Guilt By How Hot They Are Since 1999 !)
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To: fhayek

Depends, as you allude to pain is sometimes useful. In chronic cases its extremely debilitating and the treatment for pain is worse than the disease. For people with cancer, severe back injury and some of the other problems this could but huge.

Some people have problems where their brain registers pain but there isn’t an underlying cause.


10 posted on 11/28/2014 7:24:21 AM PST by driftdiver (I could eat it raw, but why do that when I have a fire.)
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To: Lazamataz

Scary, yet painless — nice.


11 posted on 11/28/2014 7:27:00 AM PST by shove_it (long ago Orwell and Rand warned us of Obama's America)
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To: Lazamataz

That’s a beautiful graphic, Laz!


12 posted on 11/28/2014 7:31:21 AM PST by Ken522
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To: Lazamataz

p.s.

Also fair and balanced.


13 posted on 11/28/2014 7:31:27 AM PST by shove_it (long ago Orwell and Rand warned us of Obama's America)
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To: ladyjane; fhayek

Or to temporarily get rid of the pain until the source of the pain is fixed.

If I have an excruciating toothache and I can’t see the dentist until the next day I would not mind getting rid of the pain while I’m waiting.

Or say, childbirth.


14 posted on 11/28/2014 7:32:45 AM PST by aquila48
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To: shove_it

15 posted on 11/28/2014 7:35:25 AM PST by smoothsailing (Mel Kaminsky for President!!!)
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To: shove_it

If the process of blocking pain via this method is reasonably instantaneous, I can see a lot of benefit with surgery. Deaths from anaesthesia could become a thing of the past.

Also, the various neuropathies as well as other forms of debilitating chronic pain could be alleviated. Phantom pain from a lost limb, for instance.


16 posted on 11/28/2014 7:40:19 AM PST by RegulatorCountry
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To: Lazamataz

I’d hit that!


17 posted on 11/28/2014 7:48:07 AM PST by BraveMan
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To: jsanders2001

Finally, self immolation for fun.


18 posted on 11/28/2014 7:50:45 AM PST by ImJustAnotherOkie (i)
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To: shove_it
'Off switch' for pain discovered

'twas invented in Ireland long ago. My ancestors called it "The Water of Life." Had some last night while we were waiting for the turkey.

19 posted on 11/28/2014 7:57:46 AM PST by ElkGroveDan (My tagline is in the shop.)
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To: fhayek

pain only represents the bodies interpretation of something.....which is why some people can have lots of pain and still continue to work, etc, while others can’t function....


20 posted on 11/28/2014 8:11:38 AM PST by cherry
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