Well, if you’re referring to Alabama and Gov. Wallace and the school desegregation confrontation in the 60’s, the feds were actually acting constitutionally per the 14A (which authorizes the feds to interfere with the state ONLY regarding state segregation laws)- Wallace & Co. were out of line on that one.
No, I’m talking about a deliberate, good-faith effort of a state to determine whether a questionable federal act violates the text, original understanding, and intent of the Constitution. Don’t think Alabama did that back then. But the states need to do it now. Otherwise, they are relinquishing their most precious freedom to tyranny without a shot being fired. God forbid and by God’s grace many will fight for their God-given right to Life, Liberty and Free Pursuits.
I'm talking about through our history. From South Carolina trying to nullify tariffs to Northern states trying to nullify fugitive slave laws and on through the Civil War and up to today. The judiciary has taken a dim view of states trying an end run around the supremacy clause.