Every President and Congress since Washington has made use of the "implied powers" of the federal government under the Constitution. That very much includes "strict constructionists" like Jefferson and Madison. That is part of the logic of the Constitution, and is the reason why the Constitution endured and the Articles of Confederation failed.
There may be constitutional questions about the drug war, but with the growth of interstate commerce after the Civil War, it was inevitable that the federal government would use its constitutional powers to regulate interstate trade. Whether this includes aspects of the drug war is another question, but for good or ill it does provide a constitutional mandate for much of what the government does today.
The idea that the Civil War was fought between Federalists and Anti-Federalists or centralizers and state's rightists or statists and libertarians is superficially appealing. It would come as a surprise to those Wisconsans who asserted state authority against the fugitive slave acts, though, and to those Southerners who used federal coercion to get their way on this issue. It would also trouble those who witnessed the conflicts between the state governments and the Confederate government or the willingness of both to use repressive measures to preserve their power.
Similarly, the speed with which Southerners got on the progressive bandwagon in the twentieth century to use federal taxes for their own benefit makes one skeptical of the whole idea of a fixed libertarian vs. statist, South vs. North polarity in American political history. As do the claims of "state's rightists" for absolute state sovereignty and their willingness to bring all the power of the state down on those who are in their power. State's rights is another form of statism and it can be ferocious to those in its grasp.
The idea of a federal union in which we all have certain basic rights and freedom of movement from state to state was more a Lincolnian than an anti-Lincolnian idea. The alternative would have meant more power for state government, no guarantees of basic rights, and less mobility across state lines.
They quibble of who did what a hundred forty years ago, while the constitution crumbles.