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Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), successfully alleviated pain and inflammation in a rodent model of endometriosis, according to researchers. They chose the drug after using a computer algorithm to evaluate nearly 1,300 existing compounds for their ability to reverse gene expression related to endometriosis disease. Analysis by researchers using publicly available data from people with endometriosis, returned 299 candidate compounds with seven considered top candidates. These drugs included commonly used treatments for the disease, such as aspirin, as well as those not yet studied for this purpose. The researchers chose fenoprofen for further evaluation because it returned the highest...

A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say. They have shown that when rats or healthy people drink a solution of baking soda, or sodium bicarbonate, it becomes a trigger for the stomach to make more acid to digest the next meal and for little-studied mesothelial cells sitting on the spleen to tell the fist-sized organ that there's no need to mount a protective immune response. Mesothelial cells line body cavities, like the one that contains our digestive tract, and they also cover the exterior of our organs...

A faculty member and her colleagues have identified the means in which bacteria in the digestive system can break down tryptophan in the diet into an inflammatory chemical that primes the immune system towards arthritis. She says the research "builds upon some observations we had in patients with spondyloarthritis where changes in the microbiome were associated with increased production of indoles, which are what bacteria make from tryptophan." Similar changes were observed in arthritis studies involving mice, she says. "We found that when indole is present, the mice start to develop autoreactive T-cells that are more inflammatory. They have less...

Ibuprofen works wonders for your headaches, joint pain, muscle aches, and menstrual cramps, so it's probably no surprise that it's the second most common over-the-counter (OTC) drug behind paracetamol (Tylenol), according to a 2023 article https://pubmed.ncbi.nlm.nih.gov/36876700/ in the European Review for Medical and Pharmacological Sciences. You might get a prescription for ibuprofen if you have rheumatoid arthritis or osteoarthritis to reduce the pain and swelling from these conditions. Ibuprofen might also be used for psoriatic arthritis, arthritis of the spine, and gouty arthritis. Like other non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen works by blocking an enzyme that makes prostaglandins that cause...

Researchers show that antibody therapy can be effective against erosive hand osteoarthritis. Using the antibody denosumab leads to bone remodeling and the prevention of erosive joint damage. This is the first evidence that erosive progression can be halted in this disease. While current therapies can alleviate symptoms, they do not address the structural damage in the affected hands. Recent research, however, suggests that people with erosive hand arthritis have other issues as well. Overall, their bones are thinner and they lose bone and cartilage as the condition progresses, even in bones and joints that are not immediately affected by the...

A new study has confirmed the effectiveness of JAK inhibitors in treating rheumatoid arthritis. The Japanese multicenter, retrospective study found high remission and low disease activity rates among patients, with the majority continuing treatment. This success highlights the potential of JAK inhibitors as a favorable alternative to conventional treatments, which often lead to reduced effectiveness and discomfort over time. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ A new study published in the journal Rheumatology reveals that JAK inhibitors, commonly used to treat arthritis patients, are indeed effective. Despite initial concerns about their effectiveness, this multicenter, retrospective study conducted by Japanese researchers has shown impressive remission rates...

According to a paper, JAK inhibitors, which doctors have used to treat patients with arthritis despite concerns about the effectiveness of such drugs, actually do work quite well. In a multicenter, retrospective study Japanese researchers found that the drugs resulted in impressive remission rates in patients, most of whom choose to continue such treatment. Rheumatoid arthritis is a common autoimmune disease. The use of biological disease-modifying drugs enables patients to enjoy the achievement of low disease activity and remission. But clinics must administer such drugs through subcutaneous or intravenous routes, which is unpleasant for patients. Recently scientists have developed Janus...

The amount of environmental exposure to polycyclic aromatic hydrocarbons, or PAH for short, is strongly linked to a person's risk of developing rheumatoid arthritis, suggests research. These chemicals, formed from the burning of coal, oil, gas, wood, or tobacco as well as the flame grilling of meat and other foods, also seem to account for most of smoking's impact on risk of the disease, the findings indicate. The researchers drew on the U.S. National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016. NHANES evaluates a wide variety of toxicants, along with data related to health, nutrition, behaviors and...

Painful, stiff or swollen joints are a common complaint among older adults, and for many, may be the first sign of arthritis - but the condition shouldn’t be an inevitable part of growing older as it can be avoided.What was once an easy run may feel tougher to complete. Or perhaps a challenging game of tennis might leave your hip or ankle sore for days. Painful, stiff or swollen joints are a common complaint among older adults — and for many, they’re the first sign of what may feel like an unavoidable diagnosis: Arthritis. In a 2022 survey of more...

Being overweight may be physically changing the environment within people's joints, as new research suggests that obesity is promoting pro-inflammatory conditions which worsen arthritis. In a study, researchers have found that specific cells in the joint lining tissue (synovium) of patients with osteoarthritis are being changed due to factors associated with obesity. Previous research has shown that fat tissue that has been metabolically altered by obesity releases proteins called cytokines and adipokines, which are known to promote inflammation around the body. The newly published study observed that in cells taken from biopsies of arthritic joints, obesity also changes the environment...

A large study of women with rheumatoid arthritis has found that those taking oral contraceptives or hormone replacement therapy (HRT) had a greater chance of achieving remission. The study revealed the following: Pre-menopausal women (those still experiencing a regular menstrual cycle) reported fewer RA symptoms than peri-menopausal (irregular or infrequent periods) or post-menopausal women with RA. RA patients using HRT or oral contraceptives in combination with the drugs prescribed for rheumatoid arthritis had a much greater likelihood of remission. Post-menopausal women, comprising 63% of the participants, of whom only 8% were using HRT, were less likely to achieve RA remission...

Two studies comparing injections commonly used to relieve the pain of knee osteoarthritis found that corticosteroid injections were associated with the progression of the disease. Osteoarthritis is the most common form of arthritis, affecting 32.5 million adults in the U.S. Knee osteoarthritis is a chronic, degenerative and progressive condition with an estimated incidence of 800,000 patients each year. More than 10% of patients with knee osteoarthritis seek noninvasive treatment for pain relief through corticosteroid or hyaluronic acid injections. In the first study, MRI was performed on all patients at the time of the injection and two years before and after....

Abstract The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the bodyÂ’s use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and...

Well . . . . . it has begun.I was told when I was younger that I would more than likely develop arthritis and now, at 74, My hands are quickly becoming sore and stiff albeit not RA type deformed. I have access to OTC pain creams and rather than ask about this one or that, what are my fellow FReepers using to keep their nimble fingers nimble.All orgamic ?Lidocain ?etc.Thanks

Short sleep duration is causally associated with an increased risk for rheumatoid arthritis (RA), according to a study.. Rui-Chen Gao and colleagues examined whether sleep disorders are causally associated with RA. Seven sleep-related traits were selected: short sleep duration, frequent insomnia, any insomnia, sleep duration, getting up, morningness (early-to-bed/up habit), and snoring and 27, 53, 57, 57, 70, 274, and 42 individual single-nucleotide polymorphisms were obtained for these traits as instrumental variables. Outcome variables were obtained from a public genome-wide association study, including 14,361 cases and 43,923 controls of European ancestry. A two-sample Mendelian randomization (MR) analysis using inverse variance...

Patients with inflammatory bowel disease (IBD) more often have spondyloarthritis (SpA) before and after diagnosis of IBD, according to a study recently published in the Journal of Crohn's and Colitis. Sarita Shrestha, from Örebro University in Sweden, and colleagues compared the occurrence of SpA in a nationwide cohort study involving 39,203 patients diagnosed with IBD during 2006 to 2016 and 390,490 matched reference individuals from the general population. The researchers found that compared with reference individuals, IBD patients were more likely to have prevalent SpA at IBD diagnosis (2.5 versus 0.7 percent; odds ratio, 3.48). IBD patients also more often...

Annie England Noblin, a 40-year-old resident of rural Missouri, had never had a problem filling her monthly prescription for methotrexate until this week. …… It also happens to be one of the first medicines prescribed by doctors to treat rheumatoid arthritis

The left image shows a knee joint in a healthy rat. (White indicates cartilage.) The second image from the left shows a joint with grade 2 untreated osteoarthritis. The third image shows a joint with osteoarthritis that has worsened from grade 2 to grade 4 after six weeks of placebo therapy. The right image shows a joint with osteoarthritis that improved from grade 2 to grade 1 (mild) after six weeks of combination therapy with alphaKlotho and sTGFbR2. Credit: Salk Institute ***************************************************************** A combination of two previously studied osteoarthritis drugs works better than either drug alone. People with osteoarthritis, or...

Two rheumatoid arthritis drugs show potential for lowering the risk of Parkinson's disease, new research shows. Some previous studies have found that people with rheumatoid arthritis have a lower risk of Parkinson's, and it was suggested that a class of rheumatoid arthritis drugs called disease-modifying antirheumatic drugs (DMARDs) may play a role in that reduced risk. To learn more, researchers analyzed data from thousands of patients in Finland. The use of most DMARDs—including methotrexate, sulfasalazine, gold preparations or immunosuppressants—at least three years before Parkinson's disease diagnosis was not associated with the risk of the disease in those with rheumatoid arthritis,...

Study of older adults is 'first direct evidence' of protection against rheumatoid arthritis, psoriasis, other conditions In a new study, investigators from Brigham and Women’s Hospital found the people who took vitamin D, or vitamin D and omega-3 fatty acids, had a significantly lower rate of autoimmune diseases — such as rheumatoid arthritis, polymyalgia rheumatica, autoimmune thyroid disease, and psoriasis — than people who took a placebo. With their findings published Wednesday in BMJ, the team had tested this in the large-scale vitamin D and omega-3 trial (VITAL), a randomized study which followed participants for approximately five years. Investigators found...