A team of scientists led by Duke-NUS Medical School have identified an important pathway that gets disrupted in the advanced form of non-alcoholic fatty liver disease known as non-alcoholic steatohepatitis (NASH)—and intervening with a naturally-occurring compound known as spermidine partially fixes the problem. "Currently, there is no pharmacological therapy for NASH, with several drugs showing only limited efficacy in clinical trials, so there is an urgent need to better understand the molecular mechanisms that underlie it," said the study's first author Dr. Zhou Jin. Dr. Zhou, senior author Professor Paul Michael Yen from the CVMD Program, and their colleagues in...