Regarding the DNA, when they have a sample of the Indian (Lumbee, etc.) and see an anglo mix, what will they compare it to? Are there known descendants/relatives of the original 116 around today? If not, an anglo mix (highly probably) does not necessarily mean mix with the Roanoke settlers.
We know that various mixes arose. Groups like the melungeons are still around. I’ve also read about groups of natives that didn’t quite fit with surrounding tribes.
There are still surnames of the original settlers around there that have been in the area for centuries. Anyone interested in this mystery should read the book about Roanoke Island written by Lee Miller a few years ago. She theorizes that they moved inland and it had to do with copper. She also believes that political forces in England had something to do with it. I forget the details.