Bryan Cranston just did a movie about gaming the lottery system. For all the work the real life couple put in the net profit was slim but far more than they probably made their whole life. They had 18 million losing tickets or cost of tickets in tubs in the garage.
Estimated profit was around 8 million
I can only think of two ways to game the system.
1) Have someone on the inside that can skew the results in your favor.
2) Play based on the assumption that the lottery results are not truly random. This could happen in the old blown ball systems due the possibility that some balls had more friction than others and therefore were more likely to reoccur. Or it could happen in a computerized system if the Random Number generator is not truly random. Or one system had a problem in the programming where an entire range of numbers were excluded from the possible results.