Posted on 01/18/2024 9:36:01 AM PST by ConservativeMind
A population-based cohort study of more than 10,000 persons using gabapentinoids found that their use was associated with an increased risk of chronic obstructive pulmonary disease (COPD) exacerbation. This study supports the warnings from regulatory agencies and highlights the importance of considering this potential risk when prescribing gabapentin and pregabalin to patients with COPD.
Gabapentinoid drugs are anticonvulsant drugs indicated for the treatment of epilepsy and neuropathic pain. Despite limited indications, its prescription has surged across North America and Europe, which may partly stem from excessive off-label prescribing. However, these drugs have been reported to cause central nervous system depression, leading to sedation and respiratory depression in animal and human studies. This safety issue may be of particular concern in patients with respiratory diseases like COPD.
Researchers from McGill University and Lady Davis Institute for Medical Research studied insurance data for 356 gabapentinoid users with epilepsy, 9,411 with neuropathic pain, and 3,737 with other chronic pain.
The gabapentinoid users were matched 1:1 to nonusers on COPD duration, indication for gabapentinoids, age, sex, calendar year, and time-conditional propensity score. The authors found that compared with nonuse, gabapentinoid use was associated with an increased risk for severe COPD exacerbation among users taking these drugs for epilepsy, neuropathic pain, and chronic pain, and peak increase in risk for severe COPD exacerbation occurred after approximately six months of continuous use.
Among patients with neuropathic pain and other chronic pain, the risk was observed regardless of age, sex, number of prior COPD exacerbations, prior use of inhaled corticosteroids (ICS), number of respiratory medications used, or opioid or benzodiazepine use. According to the authors, physicians should consider these potential risks before prescribing gabapentin and pregabalin to patients with COPD.
(Excerpt) Read more at medicalxpress.com ...
for me, gabapentin induced mental insanity ... felt like i was in Hell ...
Well glad the doctor was able to fix it.
Both me and then my father had nerve pain (for different reasons) and gabapentin was less effective than aspirin. We both got better through nerve blocks.
I was put on Gabapentin to relieve sciatic pain prior to spine surgery. I can't say I noticed any major improvement. What I did notice was a dramatic improvement for Restless Leg Syndrome (RLS) which was not previously relieved by other drugs. After surgery for my back I continued to take a reduced dosage (900mg) of Gabapentin to successfully control the RLS.
Some people can’t tolerate it because it puts them to sleep. I have an acquaintance who loved it to relieve Shingles pain.
LOL!
No, those are Graboids!
I LOVE Tremors.
It’s great fun to watch!
https://screenrant.com/every-tremors-movie-chronological-order/
Dang! Great news!
Oh, never mind.
LOL
Okay!
Heck, look around, we all feel that way these days!
>>Has anyone seen any effect from taking this drug?”
The usual...
Dizziness and daytime sleepiness.
But 300mg is keeping my RLS and leg neuropathy in check. Readily observed when I miss a dose. RLS occurs every 20 seconds, keeping me from falling asleep when I need sleep.
A sleepness condition can lead to depression and suicide ideation. “Sleep deprivation” is used in Western military interrogations.
There's a word you don't hear very often.
Every time I go to the doctor about chronic pain in my foot and ankle they try to prescribe me Gabepentin. I tried it once for three months a few years ago. It did absolutely nothing but make me gain weight and seemed to mess with my thought processes.
My sisters and I have assorted but different ailments (hey, we are getting old!), and everyone of us have been prescribed that drug. It didn’t help any of us. My oldest sister who trusted doctors and took every dang drug they prescribed, including the stupid clot shots, took it for years and at the end was taking something like 3600 mg a day. She developed COPD, then cancer. She died last September.
Interesting...
When I had shingles above my left eye, there was no pain after the very first few moments of occurance.
Yes, Bad effects
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