Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Stool transplant shows promise for Parkinson's disease (“Significant improvement” in motor skills)
Medical Xpress / VIB (the Flanders Institute for Biotechnology) / eClinicalMedicine ^ | April 4, 2024 | Arnout Bruggeman et al

Posted on 04/06/2024 8:12:45 AM PDT by ConservativeMind

Parkinson's disease (PD) is a common neurodegenerative disease that affects millions worldwide. Now, a groundbreaking clinical study has demonstrated the potential of fecal microbiota transplantation (FMT) to improve symptoms in patients with PD.

Motoric symptoms, such as balance problems, stiffness, and the characteristic tremor, are the best known and almost always the reason for the eventual diagnosis. However, non-motor symptoms, such as loss of smell, constipation, and REM sleep disturbances, often develop up to 20 years before diagnosis in a large number of people with the disease.

In Parkinson's disease, a protein called alpha-synuclein misfolds and clumps together. Those clumps then damage dopamine-producing nerve cells in the brain, which leads to the typical Parkinson's symptoms.

The protein clumps are believed to be formed in the gut wall at a very early stage of the disease, from which they reach the brain cells via the vagus nerve, which connects the gut and the brain. This process can be influenced by gut bacteria.

Patients with Parkinson's often have an altered gut microbiome compared to healthy individuals and they often show more (intestinal) inflammation and a disrupted intestinal barrier.

The clinical study showed after 12 months, the actively treated group showed significantly more improvement in motor symptoms compared to the placebo group.

"Our results are really encouraging!" says Dr. Arnout Bruggeman. "After twelve months, participants who received the healthy donor stool transplant showed a significant improvement in their motor score, the most important measure for Parkinson's symptoms."

The improvement in motor symptoms became even more pronounced between the sixth and twelfth month after the transplant, suggesting a potential long-lasting effect. Additionally, participants had less from constipation, a frequent and bothersome symptom for many people with Parkinson's disease. More research is needed to determine whether this treatment also slows the progression of the disease.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: fecaltransplant; medicalxpress; microbiota; nerve; parkinsons; stooltransplant; transplant; vagus
Navigation: use the links below to view more comments.
first previous 1-2021-36 last
To: aMorePerfectUnion

My wife says Im not eligible for a fecal transplant, Im already full.


21 posted on 04/06/2024 10:08:22 AM PDT by Ikeon (I get up nice every morning and then, I run into stupid persons one after another until I give up. )
[ Post Reply | Private Reply | To 10 | View Replies]

To: ConservativeMind

Gut bacteria have Bern known to be helpful for a long long time.

THE MAKING OF A SURGEON 1964


22 posted on 04/06/2024 10:48:12 AM PDT by Chickensoup
[ Post Reply | Private Reply | To 1 | View Replies]

To: ComputerGuy

He gave me a load of shit...


23 posted on 04/06/2024 11:07:14 AM PDT by DPMD (ua)
[ Post Reply | Private Reply | To 3 | View Replies]

To: Ikeon

"Please, can we have your poop?"

24 posted on 04/06/2024 11:10:12 AM PDT by dfwgator (Endut! Hoch Hech!)
[ Post Reply | Private Reply | To 20 | View Replies]

To: ConservativeMind

Three people with MS were also healed by fecal transplants. Shhh. Big pharma keeps that buried.


25 posted on 04/06/2024 11:36:08 AM PDT by aimhigh (1 John 3:23 "And THIS is His commandment . . . . ")
[ Post Reply | Private Reply | To 1 | View Replies]

To: Revel

Ask me if I know Pancho Villa...


26 posted on 04/06/2024 12:34:53 PM PDT by Eccl 10:2 (Prov 3:5 --- "Trust in the Lord with all your heart, and lean not on your own understanding")
[ Post Reply | Private Reply | To 18 | View Replies]

To: ConservativeMind

Too late, a good friend of mine died a couple of months ago due to complications of Parkinson’s, and two more went before him, one of them was my best friend of many years. It’s a nasty disease.


27 posted on 04/06/2024 2:45:44 PM PDT by Fresh Wind (Nothing says "Democracy" like throwing your opponents in jail.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Fresh Wind

I have a brother-in-law with Parkinson’s. I’ll have to let him know about this.
He’s using a walker at present. I wonder if there is a “point of no return” when this therapy won’t work…


28 posted on 04/06/2024 5:58:39 PM PDT by telescope115 (I NEED MY SPACE!!! 🔭)
[ Post Reply | Private Reply | To 27 | View Replies]

To: ConservativeMind

You can take one of these wherever you go, no need for a transplant!

https://farmandranchdepot.com/Milking_Stools/


29 posted on 04/06/2024 6:05:59 PM PDT by 9YearLurker
[ Post Reply | Private Reply | To 1 | View Replies]

To: ImJustAnotherOkie

😄


30 posted on 04/07/2024 5:36:01 AM PDT by yelostar (Spook codes 33 and 13. See them often in headlines and news stories. )
[ Post Reply | Private Reply | To 12 | View Replies]

To: ConservativeMind

31 posted on 04/08/2024 5:50:00 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 2 | View Replies]

To: moovova

That’s a BIG STOOL!.....................


32 posted on 04/08/2024 5:50:45 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 4 | View Replies]

To: dfwgator

33 posted on 04/08/2024 6:21:21 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 5 | View Replies]

To: ConservativeMind

I think I read they sterilize the poop, freeze-dry it, and put it in a capsule to swallow.


34 posted on 04/19/2024 1:49:56 PM PDT by muggs
[ Post Reply | Private Reply | To 2 | View Replies]

To: muggs

They do not sterilize it, at all.

That’s why it works. The good germs come over.


35 posted on 04/19/2024 1:51:45 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 34 | View Replies]

To: ConservativeMind

Thanks, bad memory so I might be remembering wrong.


36 posted on 04/19/2024 5:11:47 PM PDT by muggs
[ Post Reply | Private Reply | To 35 | View Replies]


Navigation: use the links below to view more comments.
first previous 1-2021-36 last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson