From the study:
They gave cnicin as an intravenous application of the compound at 2 µg/kg.
“Retinal cultures were incubated with cnicin (0.25-5.0 nM in DMSO).”
“To investigate cnicin's bioavailability, the same dose (800 µg) was administered orally. In this case, peak plasma concentrations reached 29.5 ± 9.3 µM and were approximately 6 times lower than after intravenous application…The absolute bioavailability for oral administration of cnicin was high, reaching 84.7% (point estimate). This is consistent with similar pharmacodynamic effects following both intravenous and oral administration.”
Were these doses administered to mice or humans. I appear to hav damaged one optic nerve by violent coughing over a 3 1/2 month coughing/bronchial illness about a year ago. I have added NAC and Inositol to my usual supplements, and now am considering adding Blessed Thistle, but what dose?
Is that 800ug per kg? 800ug = 0.8 mg. In my case, that would be 61 mg. A quick look at supplements on Amazon shows that most capsules contain 750 to 1,100 mg each.