[Harmless Teddy Bear]

You can tell because you are not the one who notices the change.

And many times you are taking the drugs just to please someone else not in any real hope of improvement.

[9YearLurker]

Sorry—I meant to pose this question to you: do you therefore doubt the placebo effect in general? (It has been found to cause physiological changes than can be objectively observed by others—not just subjective observational bias.)