State nullification of national laws would render the union a confederacy of independent states.
Precisely what the founding fathers said we were independent States. I might leave out the word confederacy as that smacks of 1777, but States loaned the Federal Government the power to exist, not fundamentally change the way government operated, amendments notwithstanding. After the Civil War, States were bullied into seeing the Fed as their overseer not as it should be the Fed at the mercy of the States except for Article 1 Section 8 of the Constitution that clearly says what government is allowed to be engaged in.
I’ve written extensively about nullification and sovereignty.
If you keyword either at my website, you’ll get several hits on each.