Here is my response.
Saccharine was an interesting study in differential biology.
Humans, generally, excrete a great deal of water compared to the amount of actual waste in our urine.
Rats, particularly male rats, produce an extremely concentrated urine. That’s normally OK ... that’s how God made rats to work. When fed extremely large quantities of sacharine, however, they have a problem. The saccharine crystalizes in their bladders; the crystals cause chronic irritation to the inside of their bladders, which causes them to develop bladder cancer.
So: if you’re a male lab rat, don’t eat a lot of saccharine: it might give you bladder cancer. If you’re a human, it won’t hurt you ... it just tastes like crap. And if you’re a bureaucrat, take a long walk off a short pier.