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Abstract
Impaired wound healing is a major complication of diabetes. Recent studies have reported reduced lymphangiogenesis and angiogenesis during diabetic wound healing, which are thought to be new therapeutic targets. Statins have effects beyond cholesterol reduction and can stimulate angiogenesis when used systemically. However, the effects of topically applied statins on wound healing have not been well investigated. The present study tested the hypothesis that topical application of simvastatin would promote lymphangiogenesis and angiogenesis during wound healing in genetically diabetic mice. A full-thickness skin wound was generated on the back of the diabetic mice and treated with simvastatin or vehicle topically. Simvastatin administration resulted in significant acceleration of wound recovery, which was notable for increases in both angiogenesis and lymphangiogenesis. Furthermore, simvastatin promoted infiltration of macrophages, which produced vascular endothelial growth factor C in granulation tissues. In vitro, simvastatin directly promoted capillary morphogenesis and exerted an antiapoptotic effect on lymphatic endothelial cells. These results suggest that the favorable effects of simvastatin on lymphangiogenesis are due to both a direct influence on lymphatics and indirect effects via macrophages homing to the wound. In conclusion, a simple strategy of topically applied simvastatin may have significant therapeutic potential for enhanced wound healing in patients with impaired microcirculation such as that in diabetes.

Standard therapies in Europe right now should be investigated by those with diabetes or who have family members afflicted.

This include a normal, daily supplement of vitamin B-1. The excess urination caused by diabetes results in a loss of albumin, which in turn causes many severe problems to the kidneys and liver. B-1 preserves albumin levels so is essential to those with diabetes. Not megadoses, just normal amounts, like 100mg a day. Please research it.

A less common therapy is R-Alpha Lipoic Acid. (Note: though ALA is fairly common as a supplement, R-ALA is less available, usually only through mail order.) In specific, R-ALA is used to stave off or even partially reverse diabetic neuropathy (nerve damage leading to numbness) in the extremities. Please research it.

Somebody in the Veterans Administration should compare the rate of lower extremity amputations in diabetics already on statins to diabetics not on statins. If the difference is staically significant, then divert funds from the really stupid studies that the NIH funds, e.g. NIH sends more than $90 million in taxpayer-funded grants to China, and fund a double blind, randomized controlled trial of oral statins in diabetics and lower extremity amputations.

Weight Loss Surgery May Not Combat Diabetes Long-Term

Robert Lustig’s “Sugar: The Bitter Truth” lecture

Fructose in fruit is OK as long as its eaten in normal amounts. Dr. Lustig is on the warpath about any kind of processed fructose including table sugar. "Fructose is ethanol without the buzz." Fructose can be toxic to your liver like ethanol. It uses many of the same metabolic pathways. It screws up normal hormonal "feedback" loops that tells your brain that you hve eaten enough carbohydrates, especially glucose.

If you haven't seen it, set aside 90 minutes and watch it. It's certainly the best Youtube I have ever seen.

FReepmail me if you want on or off the diabetes ping list.

Somebody in the Veterans Administration should compare the rate of lower extremity amputations in diabetics already on statins to diabetics not on statins. If the difference is staically significant, then divert funds from the really stupid studies that the NIH funds, e.g. NIH sends more than $90 million in taxpayer-funded grants to China, and fund a double blind, randomized controlled trial of oral statins in diabetics and lower extremity amputations.

Weight Loss Surgery May Not Combat Diabetes Long-Term

Robert Lustig’s “Sugar: The Bitter Truth” lecture

Fructose in fruit is OK as long as its eaten in normal amounts. Dr. Lustig is on the warpath about any kind of processed fructose including table sugar. "Fructose is ethanol without the buzz." Fructose can be toxic to your liver like ethanol. It uses many of the same metabolic pathways. It screws up normal hormonal "feedback" loops that tells your brain that you hve eaten enough carbohydrates, especially glucose.

If you haven't seen it, set aside 90 minutes and watch it. It's certainly the best Youtube I have ever seen.

FReepmail me if you want on or off the diabetes ping list.

My 19 yo granddaughter has just been diagnosed with Type 2 Diabetes, full blown. her blood sugar has been up well over 400, but is on meds and it is starting to get under control. She had no idea that she was sick until she had to have a physical as she is getting her BSN and going to be in the hospitals next semester. My question is because she is highly motivated to get perfect scores, could this have been brought on by stress? Sorry about the long paragraph

If the issue is assisting wounds to heal, you might try applying a few drops of Lavender Essential Oil directly into the wound. The Lavender oil does not sting or hurt, does kill bacteria, and promotes healing.

I had a 3 inch incision on my arm last month (connecting an artery to a vein), applied a few drops of Lavender oil several times a day to the incision (no bandage), and it was pretty much healed within a week. It made me a believer.

My wife is a diabetic; about 2 months ago she fell onto our blacktop driveway, causing gashes near her kneecaps. Lavender oil to the rescue, healed in about a week. It is first aid in a 15ml bottle, small enough to carry anywhere.