There were generations of Irish-Americans whose hackles were on permanent alert about any Brit, let alone relations with "those miserable murderin' black-hearts". When King George VI and wife visited in the US in 1939, it was said that a midwest city's mayor (Chicago?) threatened him if he were to visit the city.
So, yes you could say that there were times, even that recently, where the 'brotherly' feelings tended more to sibling irritation, at least for some.
http://irishamerica.com/2012/03/the-day-the-irish-invaded-canada/