Amateur analysis here. (based partially on other people's analysis). Starting with assuming that Brady's hand is ok. The Jaguars have to beat Brady with Fournette, and getting to Brady quickly. If they can keep the game low scoring they have a chance. But when Brady is on offense they have to cover - EVERYONE. This is a whack-a-mole game. No matter who the Jaguars cover, there is someone else to consider. Yeah, they can cover Gronk, but only so much. They have to also account for Amendola, Hogan, and Brooks. Not to mention that Brady has threatening RB's of his own with Lewis and White.
As others have pointed out, the Patriots' defense is not going to be so open as was the Steelers' defense. Jaguars are going to have to earn their points the hard way - their work is cut out for them.