AdBlock works on Chrome and Edge. Be forewarned though, some sites will hound you mercilessly to turn the AdBlock off, the two worst being FoxNews and Daily Caller.
I like to use the adblock to block the popups hounding me about the adblock.
Sometimes it makes the content inaccessible. That would be a shame if any of the content on the web was unique and/or valuable. Since it typically isn’t, I get a few minutes’ distraction fiddling with the adblocker, then either peruse the site or go elsewhere, depending on the result.
I really don’t particularly mind inobtrusive ads in the header/footer or sidebar as long as they’re not popping up, rearranging the screen, or otherwise being a nuisance (I’m talking about you autoplay-video-with-sound).
But since advertisers can’t be trusted to not make nuisances of themselves, I just block them all. I’d like to provide more revenue to the sites but my feeling is that, if the site owners were really worried about ad revenue, they’d rein in the nuisance ads. They seem to be more about tricking unsuspecting visitors into racking up trick-clicks whether or not the user actually looks at the ad. As long as that’s the game, I’m blocking it all.