Posted on 7/27/2019, 4:35:57 PM by DUMBGRUNT
GREAT RESULTS! Thanks to everyone for the help! From: A Memorial Day question about RVN JUNGLE ROT. http://www.freerepublic.com/focus/f-chat/3752249/posts
After digging through many abstracts, a couple of dozen studies and the many good recommendations…
Summary: After FIFTY PLUS YEARS OF THE CREEPING CRUD, TOLNAFTATE is the best I’ve experienced.
Your Mileage May Vary, not all jungle rot /ringworm is the same. Three dermatophyte genera and 9 species are responsible for most infections in North America and Europe. https://accessmedicine.mhmedical.com/content.aspx?bookid=2184§ionid=165459177
My review of OTC (Over The Counter) fungicides from the local Walmart.
Materials and Methods:
ALL APPLIED TWICE DAILY, and after showering. Tolnaftate 1% OTC (EQUATE) Spray Powder $3/150g
Miconazole Nitrate 2% OTC Desenex Powder $5/85g
Terbinafine Hydrochloride Cream 1% (Lamisil) OTC (Equate) $6/50g
Clotrimazole Cream USP 1% OTC NO CHANGE after five days. And it started to BLOOM!!!
Butenafine Hydrochloride Cream 1% OTC $5 / 12g https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481417/ Tacrolimus Ointment 1% Rx required $300.00/60g $75 deductible
SOAP The dermatologist recommended using a ‘mild’ soap, I DID NOT THINK TO ASK FOR A RECOMMENDATION??? Been using Dial Gold for a long time. Switched to Irish Spring Wash 5. Checking the pH by washing hands with a normal ‘feeling’ mix. I see Dial=8 and Irish Spring=6. Yes very subjective. Using a recently calibrated pH meter. I’m certain the type of soap is connected to the outcome, unsure if pH is the correct approach? The Irish Spring wash deodorant is not as effective as Dial Gold!
RESULTS:
TOLNAFTATE 1% $3/150g (Equate) Best to date, mostly clear in four days. All clear in ten days. I doubt it is clinically cured? But the symptoms are gone!!! The only anti-fungal recommended for use as a preventive. The generic (Equate Walmart) brand that I use is $2.96 and the can lasts ~13 days of twice daily plus use.
Miconazole Nitrate 2% OTC ( Desenex )Powder $5/85g Works well but does NOT finish it off.
Terbinafine Hydrochloride Cream 1% OTC (Lamisil) $6/50g Works well but does NOT finish it off. Flares up after long hot days.
Clotrimazole Cream USP 1% OTC (Equate) NO CHANGE after five days. And it started to BLOOM!
Butenafine Hydrochloride Cream 1% OTC $5 /12g \NOT TESTED/ Condition cleared by others. Does very well in trials: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481417/
Conclusions:
After FIFTY PLUS YEARS OF THE CREEPING CRUD, TOLNAFTATE is the best I’ve experienced. Tolnaftate pronounced as (tole naf' tate) Continue treatment for at least 2 weeks after symptoms disappear. A total of 4-6 weeks of treatment may be necessary. Maintenance or prophylaxis: apply once daily. https://medlineplus.gov/druginfo/meds/a682617.html
The only nonprescription agent approved for both preventing and treating tinea infections. https://www.pharmacytimes.com/publications/issue/2014/january2014/fungal-skin-infections-management-treatment-ad-preventionn
Arthroconidia (Spores, VERY SMALL) can survive for YEARS embedded in scales of hair and skin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481417/ ...Tinea cruris infection in monsoon months in India. In India, Tinea cruris infection is caused mainly by Trichophyton rubrumwhereas in Western countries, Epidermophyton floccosum is the commonest dermatophyte.
1968, Nystatin anti fungal, Triamcinolone Acetonide is an anti inflammatory. Rx. Controlled but never totally, the anti inflammatory may have been covering the symptoms?
~2010 Lamisil (Terbinafine) Worked well and quickly,(a few days), but never totally eliminating the symptoms.
June 2018 Dermatologist Rx Tacrolimus Ointment 1% Very slowly brought it under control(one month plus) 100% clear after ~twelve weeks total. Occasional symptoms and reapplication...
May 2019 With the warm weather(?) it started to BLOOM!!!
Reviewing the many recommendations and reading around, I selected four Walmart OTC anti-fungal products and a cheap low pH soap/wash.
First up, Clotrimazole Cream USP 1%. WORSE THAN ZERO!!! In four days the dreaded purple spots appeared! Reverted to Lamisil in AM, at mid day added Nystatin Rx for the itching ;only one application. Worked well! After one week of Lamisil cream twice daily, controlled but not gone.
Miconazole Nitrate 2% (Desenex power) twice daily. After ten days, almost clear and the purple spots are lightening up. Still not gone.
Tolnaftate 1% OTC Spray Powder (Equate) twice daily. After four days looking good!, ten days GONE and the purple spots are very light. NICE! After two weeks , a long hot day, mid range workout 1 hour plus average heart rate 80% plus lots of sweat, towel off and change, cut grass one hour plus (95F) more sweat, take grand kids for two mile walk(90F), take dogs for three mile spin (80F), shower. Minor symptoms reappeared and subsiding after two days. GREAT!
Notes: Cannot recall the last time I had ‘athlete's foot’?, many years.
My wife and our children never had the rot. Nor the dogs.
All about the rot. https://www.aafp.org/afp/2003/0101/p101.html
Comparison study's. https://www.cochranelibrary.com/es/cdsr/doi/10.1002/14651858.CD009992.pub2/pdf/full/es
About 15% of the population of the United Kingdom have fungal infections
Tolnaftate was developed in 1962 by Nippon Soda Company in Japan. It was soon brought to the United States by Schering Corporation (now owned by Bayer), who trademarked it as Tinactin
How tolnaftate works isn’t completely understood. It’s believed to inhibit an important enzyme in the biosynthetic pathway of ergosterol (a key component in the fungal membrane).
Tolnaftate showed activity with (0.06 μg/ml)------ microgram/mL ----- 0.06 microgram/mL = 0.06 part per million against all dermatophyte isolates**** NOTE: in vitro testing. ***NOTE: 1% tolnafate EQUALS 10,000 PPM.
In the remote possibility, anyone is curious, I posted all my (too many) notes.
Cured?
NO, but well under control, for the first time ever!
Now on once a day preventive patience.
THANK YOU FOR ALL THE HELP!!!
Grunt
marked for later ,,,, As for the mild soap ,,,, think IVORY and pine-sol are the only two I’ve ever used ,,,,
Ever try Lotrimin for athlete’s foot? Works great.
What will really get me interested is when someone really ends up with a cure for toe-nail “fungus” which is apparently a deeply embedded infection that screws up your toenails. Right now, the only true cure apparently is surgery which has it own problems.
Glad you are getting some relief.
A wide selection of products is sold under the Lotrimin name.
Some use Clotrimazole which did nothing for me?
Some use Butenafine, on my list, well recommended, but the Tolnaftate did the job. My thinking is that if something works, DON’T FIX IT! So I did not try it.
Very nice. I think a lot of vets and doctors could be bankrupted by the cheap stuff on Walmarts shelves.
Brother in law had toe nail fungus for years until a pharmaceutical rep he bought from told him about an oral drug. A daily dose took a long time but it finally cleared up.
What will really get me interested is when someone really ends up with a cure for toe-nail “fungus”
Some years back, I heard that the Lamisil pills for toenail fungus worked for the rot.
My Physician did not think so but said I could try it, but need to have a liver function test (SOP). I take near zero meds and did not like the sound of it, but took the pills. DID NOT WORK!
Last year when I tried a Dermatologist, she laughed and said, it is only about 60% effective for toenail fungus!
The fungus stuff is self feeding. It causes inflammation and then feeds on the excretions. To put a quick stop on the symptoms use cortisone-10 or calamine lotion in conjunction with your antifungal of choice. Continuous use of cortisone -10 can cause reaction also. use as per directions. In veterinary medicine they have combined cortisone-10 with a common antibiotic for quicker results. Same idea of reducing the cycle of inflammation except for bacteria.
Neither dial nor irish spring are considered mild soaps and can cause inflammation due to allergic reaction if not thoroughly rinsed.
I brought mine back from India or SEA. Tried all that you have done, but for me, Desenex worked. Been gone now years.
Fingers crossed!!!
Burned like hell initially but it never came back.
And...and...(waiting breathlessly for what I REALLY need to know)...
I think a lot of vets and doctors could be bankrupted by the cheap stuff on Walmarts shelves.
I have some kin and an old friend that are MD’s.
They do not have the time and few will pay for it.
Look at the notes I posted, no need to read them simply consider the volume. Just a bit of my working notes of the last eight weeks.
A friend of one was the Doc that sued Medicare and won requiring everybody to go in at age 65.
He sees high-end patients and wants to give then the best possible care. Medicare pays for only a few minutes time for the patient history, he said it can sometimes take hours and they are willing to spend the time and pay for it.
Some MD’s make big bucks not all of them.
Time management is essential?
The reason I kept copious notes was in case nothing worked, I would be able to QUICKLY discuss them with my Dermatologist, yes posting on FR is fun and lots of instant help.
Glad you are getting some relief.
YOU ARE GLAD!!!
LET ME TELL YOU ALL ABOUT IT...
I measured the pH and the Dial was pH 8 Irish spring pH 6?
The Irish spring was on sale!
Also once started I didn't want to introduce another variable. KISS!!!
In a year or so when the huge bottle of Irish spring is gone, I try something else. ???
Also, Irish spring is NOT soap!!! (Fat& lye), some kind of Frankenstein product called WASH!!!
I don’t know.......LOL!
Desenex worked
The second one I tried, was good but no knockout.
Miconazole Nitrate 2% OTC ( Desenex )Powder $5/85g Works well but does NOT finish it off.
Part of the problem is many different fungi, not all jungle rot /ringworm is the same.
Three dermatophyte genera and 9 species are responsible for most infections in North America and Europe, not Asia. https://accessmedicine.mhmedical.com/content.aspx?bookid=2184§ionid=165459177
I started using it instead of commercial bar "soap" (Old Spice), and a dermatitis I had on my hands and arms from an industrial coolant I came into contact with completely disappeared, with no other treatment. Obviously, for a fungus, you'd still need those medications, but I think real soap is much better at keeping the skin healthy than the industrial stuff they sell today.
Felds Namptha
I tried Fels Naptha a year or two after I got home, very uncomfortable.
Returned to the Nystatin Triamcinolone Acetonide from the VA.
I think the Nystatin cured the symptoms, not the underlying cause. It always returned.
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