I saw a recent interview with Ryan talking about pitch counts and yanking pitchers after 100. He said he once pitched a complete 12 inning game with 200+ pitches.
Not for the great Johan Santana on a damp night:
https://ftw.usatoday.com/2016/04/johan-santana-comeback-new-york-mets-no-hitter-134-pitches-terry-collins-mlb