Reversing smoke-induced damage and disease in the lung

Cell - Cell Press ^ | October 14, 2011 | Many

[Capt. Tom]

I have also been diagnosed with COPD and asthma and told the PF is not far off the horizon with everything I have gone through the last 50+ yrs, and I stuck with the occasional cigar and shot every once in a great while.

IPF is bizarre because they don't know what causes it and are grasping at straws to find out.

A few years ago a study was done on people like me with IPF and heavy smokers with known PF an they conclude the heavy smokers generally live longer.

I have been on ESBRIET(pirfenidone) for 4 years and I am doing OK at 84,inspite of a lot of other medical problems.

Everybody have a Merry Christmas. I intend too, and am looking forward to a family gathering tonight. -Tom

[ConservativeMind]

A follow on discussion from two other journal articles just started here:

https://freerepublic.com/focus/chat/3803247/posts?page=1

[ConservativeMind]

The answer is apparently at least a small “yes.” My tea, chocolate powder, grape seed extract, etc. could be encouraging an overproduction of NO that readily combines with Superoxide when in close proximity in the bloodstream, creating a super oxidant called “peroxynitrite.” From a study link I posted in an earlier post states:

“Neither superoxide nor NO is particularly toxic in vivo because there are efficient means to minimize their accumulation (72, 74). Superoxide is rapidly removed by high concentrations of scavenging enzymes called superoxide dismutases (SOD) with distinct isoenzymes located in the mitochondria, cytoplasm, and extracellular compartments. NO is rapidly removed by its rapid diffusion through tissues into red blood cells (161, 639), where it is rapidly converted to nitrate by reaction with oxyhemoglobin (Fig. 1). This limits the biological half-life of NO in vivo to less than a second, whereas the concentrations of NO relevant for cellular signaling can persist in phosphate-buffered saline for an hour (79). However, when both superoxide and NO are synthesized within a few cell diameters of each other, they will combine spontaneously to form peroxynitrite by a diffusion-limited reaction (583). In essence, every time NO and superoxide collide, they form peroxynitrite. No enzyme is required to form peroxynitrite because no enzyme can possibly catalyze any reaction as fast. NO is the only known biological molecule that reacts faster with superoxide and is produced in high enough concentrations to outcompete endogenous levels of superoxide dismutase. Consequently, the kinetics and thermodynamics of the reaction of superoxide with NO make the formation of peroxynitrite inevitable in vivo.”

In essence, having “more” NO means a higher than “normal” conversion rate of NO to peroxynitrite, which is the truly concerning problem, and not NO under normal circumstances.

Interesting.

[redinIllinois]

Thanks very much for posting...

[just Grace]

Chemtrails?

[George from New England]

“In my world “moisture” in the air is a must.”

Don’t think you live in Florida. This morning the indoor humidity was 71%. Outside even higher. So I change the must to must’nt, ran a/c til it dropped to 67% at least.