Posted on 01/25/2020 6:36:44 AM PST by ConservativeMind
"There are clear weight-loss benefits to high-protein diets, which has boosted their popularity in recent years," said senior author Babak Razani, MD, PhD, an associate professor of medicine. "But animal studies and some large epidemiological studies in people have linked high dietary protein to cardiovascular problems. We decided to take a look at whether there is truly a causal link between high dietary protein and poorer cardiovascular health."
The mice on the high-fat, high-protein diet developed worse atherosclerosis -- about 30% more plaque in the arteries -- than mice on the high-fat, normal-protein diet, despite the fact that the mice eating more protein did not gain weight, unlike the mice on the high-fat, normal-protein diet.
Razani and his team found that excess amino acids from a high-protein diet activate a protein in macrophages called mTOR, which tells the cell to grow rather than go about its housecleaning tasks. The signals from mTOR shut down the cells' ability to clean up the toxic waste of the plaque, and this sets off a chain of events that results in macrophage death. The researchers found that certain amino acids, especially leucine and arginine, were more potent in activating mTOR -- and derailing macrophages from their cleanup duties, leading to cell death -- than other amino acids.
"Leucine is particularly high in red meat, compared with, say, fish or plant sources of protein," Razani said. "A future study might look at high-protein diets with different amino acid contents to see if that could have an effect on plaque complexity. Cell death is the key feature of plaque instability. If you could stop these cells from dying, you might not make the plaque smaller, but you would reduce its instability.
(Excerpt) Read more at sciencedaily.com ...
Be sure to increase your fat intake on any low carb diet.
It would seem intermittent fasting/One Meal A Day could mitigate some concerns of a high protein diet, as well.
Leucine and arginine appear to be the worst culprits.
OMG! We’re all going to die!!!
I disagree with the study.
Every other Keto study has shown that cholesterol levels have balanced or flipped with the HDL being better. That means either this study is wrong or that the cholesterol theory of plaque build-up is wrong.
“Keto” is not supposed to be “high-protein.”
High-protein, high-carb diets could do the same.
The problem appears to be with two amino acids from protein.
The “high protein” part is the problem.
I will now only eat straw
Whey powder? Gov’t says you need 60 grams of protein a day.
It is impossible to evaluate this study without knowing what kind of fats the mice were fed. There are good fats and not- so-good fats. Were they given inflammatory vegetable oils? We also need to know what percentage of carbohydrates were fed.
I tried to find the source study for this article, but could not. Maybe someone else can.
even if true, you have to weigh the added dangers of the effect on your arteries against the added dangers being obese will cause you.
“To see if protein has an effect on cardiovascular health, we tripled the amount of protein that the mice receive in the high-fat, high-protein diet — keeping the fat constant. Protein went from 15% to 46% of calories for these mice.
The mice on the high-fat, high-protein diet developed worse atherosclerosis — about 30% more plaque in the arteries — than mice on the high-fat, normal-protein diet, despite the fact that the mice eating more protein did not gain weight, unlike the mice on the high-fat, normal-protein diet.”
Not a single mention of carbohydrates at all.
It has long been established that to gain weight, you must consume both fats and carbohydrates. But carbs are the real villain in the equation.
If the carbs the mice ate were higher than zero, they are definitely an important variable.
How to Become Gluten Intolerant: https://www.youtube.com/watch?v=Oht9AEq1798
More bs from the diet and anti fat nazis.
They hate the simple Paleo diet. It is simple and you don’t need a computer to keep track of what you eat.
It is simple, eat good meat with its normal fat and produce.
Throw away any so called diet food and any so called food that is processed with chemicals a scientist can’t pronounce.
A doctor who I saw for few years had some simple grocery buy habits.
1. Only buy food from the outer parts of the store: Produce, Dairy (real milk products), and real meat and real seafood.
2. Avoid the center of the store and all the processed foods with the poly syllables.
3. Have a snack counter in your kitchen with fruit, veggies and good nuts on top of that counter. When you get hungry, snack from that counter.
Walk as often and as far as you can.
Drink real water not some bottled sugar/dextrose and other crud posing as a diet or exercise drink.
“Mouse Study Shows.”
Never trust mice. Especially if you’re a cat, and they’re trying to tell you to cut down on protein.
When I started a keto/intermittent fasting diet last spring, my unmedicated blood pressure was 155/110. My medicated blood pressure (diovan) was much better: 135/90.
My current unmedicated blood pressure is - this morning after one cup of coffee - 110/70. Although, to be honest, these last couple of weeks it has been averaging 115/75.
155/110 without medicine. 135/90 with medicine. Or 115/75 without medicine.
I’m not a mouse. Just reporting the change in blood pressure over a 9 month period.
In other words, do Keto: 20% calories from protein, 75% from fat, and 5% carbs.
46% of the mice’s calories were protein.
For an adult human on a 2000 calorie a day diet that would work out to approximately 200 plus grams of protein a day. That’s insanity.
That much protein, and the person would begin to other health problems long before their arteries clogged up.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.