To: wastoute
I found influenza encephalitis to be the most compelling, however not confirmed. The increase in PD now, including far younger onset is most disturbing.
My hypothesis (model) not including Huntingtons is the neurodegeneration is a metabolic process involving disruption of the sulfur cycle. We have confirmed it with miRNA testing. The primary disruption begins with PANK and involves cysteine, glutathione, cysteamine and hypotaurine. All are related to ROS scavengers. Taurine is secondary to hypotaurine and is causative to sarcopenia wasting and frailty. PKAN is the rosette stone of neurodegeneration.
I think they should have continued the Huntington's trials with cysteamine for longer (increased BDNF in the short trial), however I suspect Huntington's is genetic and not metabolic.
I disturb a few neurosurgeons when I suggest we can eliminate DBS in the near future.
Understand where I'm coming from now?
27 posted on
03/27/2020 12:51:38 AM PDT by
PA Engineer
(Liberate America from the Occupation Media.)
To: PA Engineer
LOL. Not a bit. Thats probably why my daughter wont talk neuroscience with me. Sulfur cycle? OK, I made As in three semesters of Biochem but Lehninger was a pamphlet in those days.
Didnt we know Huntingtons involves storage disease due to, cant remember, funny, I used to know the chemical structure, a complex Hyaluronic something or other? If I recall sulfur was part of it which seemed unusual but maybe not for a glycoprotein.
29 posted on
03/27/2020 12:58:03 AM PDT by
wastoute
(Government cannot redistribute wealth. Government can only redistribute poverty.)
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