Posted on 05/05/2020 1:30:43 PM PDT by ransomnote
Authors: Moussa Saleh , James Gabriels , David Chang , Beom Soo Kim , Amtul Mansoor , Eitezaz Mahmood , Parth Makker , Haisam Ismail , Bruce Goldner , Jonathan Willner , Stuart Beldner , Raman Mitra , Roy John , Jason Chinitz , Nicholas Skipitaris , Stavros Mountantonakis , and Laurence M. Epstein
Abstract
Background - The novel SARs-CoV-2 coronavirus is responsible for the global COVID-19 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine ± azithromycin for the treatment of COVID-19. Use of these medications alone, or in combination, can lead to a prolongation of the QT interval, possibly increasing the risk of Torsade de pointes (TdP) and sudden cardiac death.
SNIP
Conclusions - In the largest reported cohort of COVID-19 patients to date treated with chloroquine/hydroxychloroquine {plus minus} azithromycin, no instances of TdP or arrhythmogenic death were reported. Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. Further study of the need for QT interval monitoring is needed before final recommendations can be made.
Anecdotal, declares Kaiser Fauci. Next.
Dr Chris Martenson pointed to studies by the WHO that were prior to COVID, that stated that while QT elongation was a known side effect of HCQ, that after hundreds of thousands of cases, no sudden death due to heart problems had occurred.
Great Americans one and all! Oh, wait....
This study examines only heart risk of HCQ. It find that there is some negative heart effects, but rarely serious enough to discontinue therapy.
HCQ does not benefit Gilead. It cheap to provide and administer.
Simple as that.
NB: A majority of the NIH “independent” Data and Safety Monitoring Board member have or have been funded by or otherwise connected with Gilead.
Also, Remdesivir’s survival benefit has a p-value of 0.059. For studies such as this, the p-value must be 0.050 or lower to be statistically significant.
But Remdesivir is a Gilead patented product, and each course of treatment will cost thousands.
I’ve been feeling poorly, nagging dry cough, terrible (really bad) nausea, pink eye started, some chest pain, unexplained and very uncharacteristic red rash on left ankle, tiredness. On the plus side, good blood O2, no breathing trouble and no lung congestion. I figured I might have it, so talked to emergency doc yesterday. He said if I had it, there’s nothing that can be done so go home and rest ; call us if it gets worse.
I was shocked by that response. I mentioned the East Virginia Medical School recommended protocol for various stages of CV (HCQ, Az, Zn) and it was as though he hadn’t heard of it. That was discouraging, to say the least.
Feeling quite a bit better today. Seems like my annual bout of bronchitis or maybe severe allergies.
I thought Zinc had to be part of the therapy. Also that doxycycline could be substituted for the Zpack where there are cardiac or drug interaction problems.
Fauci must be a witch doctor. . . .
Re: Zinc - according to some, including an FR doc, he considers the zinc to be possibly helpful, and most likely not harmful. His thought is unless you’re zinc deficient, it may not be helpful. But that it doesn’t hurt to use it.
He’s been treating with HCQ and the Z-pack with good results.
The QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart. It is calculated as the time from the start of the Q wave to the end of the T wave, and approximates to the time taken from when the cardiac ventricles start to contract to when they finish relaxing.
So, prolongation of the QT interval means the time between when the cardiac ventricles start to contract to when they finish relaxing is extended.
Torsades de pointes
Torsades de pointes or torsade de pointes, is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram. It was described by French physician François Dessertenne in 1966. Prolongation of the QT interval can increase a person's risk of developing this abnormal heart rhythm.
So, they are saying that the extended time of the QT interval may possibly increase the risk of Torsade de pointes (TdP) and sudden cardiac death.
But no deaths occurred due to the QT interval extension. Furthermore, the use of these medications resulted in QT prolongation, but clinicians seldomly needed to discontinue therapy. They do not further explain if, or how many, they may have discontinued the therapy on.
He’s a Klintoon-Osambo ass kisser acolyte.
"Treatment was either not started or discontinued, when QTc (Bazett’s formula) was >500ms."
https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf [PDF]
Is it standard practice in other countries?
A few weeks ago I saw a poll which indicated that American doctors were less willing than doctors in other countries to use the HCQ protocol. I have since heard “anecdotal” stories saying the same thing.
Did you ask the ER doc about putting you on the 3 drug cocktail that has good results when started at the first signs of this covid thing?
To stop the return of manufacturing of products back to the US that went to China. China backers here who’s family members are making millions from China through their political connections will be hit hard are also claiming that Trump’s alleged stock ownership in a quinine pills maker claim its a controlling interest in a product to be totally ineffective and when used requires a severe restriction of movement when near a possible carrier known as a shutdown because of its rapid transmission .
I didn’t ask him because I was going to go back this morning for a COVID test. But I felt so much better this morning that I cancelled it. If I had taken the test, I certainly would have brought it up.
I’ve been taking the supplements I’ve been reading about on MedCram and elsewhere: Airborne for about a month, then added more Vit C and Vit D about a week ago; was just starting NAC (N-Acetyl-Cysteine); and just received Quercitin today (haven’t taken any). I was wondering if these were causing the stomach distress (a common side effect), so I discontinued all of them. I wasn’t taking high doses — pretty much the recommended dosage.
I’m taking many of those myself as a prophylactic.
I feel fine right now. Glad you’re feeling a lot better.
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