Even less in the Americas.
Deaths from European diseases brought to the Americas - likely in the millions a year.
Inquisition on purpose deaths.
Disease in Americas not on purpose.
Now add in all the deaths to Europeans and those of European ancestry from tobacco from Americas.
Yes
Locally, by 1775, the population of the total Cherokee nation was estimated to be only 9,000 to say 12,000 people. As a result of the decline, previously populated lands were deserted. The living population withdrew to more concentrated villages.
The withdrawal left a vacuum that was relieved by European, mostly Scottish and British settlers in East Tennessee, South West Virginia and North Carolina
However, in our South West and in Mexico and Peru, thousands were killed by the orders of the Church
The plague in the North American Continent took between 80-90% of the population. It is the reason they were conquered so easily—there were relatively few of them left.
Aside from NOT coming west, I am not sure what could have been done to prevent that. And the Settlers in North America had little to do with that.
The Settlers in North America killed them outright with firearms; but the damage had been done by disease 100 years earlier.
Eventually—even if Cortez had not infected the Mexican people, trade would have commenced as the Western Europeans reached the resource rich North American Continent. Literally, with first contact, he diseases would would have been spread. The deaths would have occurred in the 1600s rather than the 1500s.
This is what happens.