Posted on 04/03/2021 7:52:26 PM PDT by ConservativeMind
Abstract
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading to increased cellular proliferation and tumour burden. Saturated fat intake (SFI) is also associated with an enhanced MYC transcriptional signature in prostate cancer patients. The SFI-induced MYC signature independently predicts prostate cancer progression and death. Finally, switching from a high-fat to a low-fat diet, attenuates the MYC transcriptional program in mice. Our findings suggest that in primary prostate cancer, dietary SFI contributes to tumour progression by mimicking MYC over expression, setting the stage for therapeutic approaches involving changes to the diet.
(Excerpt) Read more at nature.com ...
The supplemental Excel tables at the bottom are very detailed down to the metabolites affected and even the specific fatty acids.
It would seem cutting out some fatty acid components would reprogram the cancer in scope. Also, possibly losing weight would rectify the abnormal metabolism. Finally, it seems a key issue found was with very low methyl metabolism. This latter issue might be addressed by supplementing with methylation products, with Betaine Anhydrous (trimethylglycine) being a cheap, generally harmless provider of three methyl groups per molecule.
From just one of the supplemental tables:
This one shows the metabolic pathways influenced, either sped up or slowed down.
Garsh.
Who paid for this study?
When you consider how delicious bacon is, this just doesn’t seem fair!
We will all die of some form of cancer someday. Lung, brain. Rectall, skin, liver or prostrate. Most of these can be kicked down the road so we did of something else first
Nobody gets out alive. It’s not how you die that matters; it’s how you lived
Who paid for this study?
The National Vegetable Advisory Board
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Sure. Right. Pass the chips!
“Who paid for this study?”
PETA?
Ping of general male health interest.
Well said, Hodar.
Thanks for posting! I will read it tomorrow. (Tired is stupid!!) good night!
So this is not a report on how HFD might increase4 the risk of prostate cancer in general population - just in those who have existing prostate cancer.
Too bad ALL men over 50 can have a few "atypical" cells in the prostate.
So first of all they need to control the study better to figure out if it is saturated fat -or- obesity -or- both. Or else as you were explaining if they narrowed it down to 60% saturated fat diets then this was a poorly written summary.
I don't know how one can consume a consistent diet of 60% saturated fats unless ordered to by scientists. And as you said, the effects could be neutralized by dietary modifications.
I am on a low carb diet for the last 8 or 10 weeks, but I also don't eat a lot of saturated fats. And I dropped about 20 lbs of "tire" which was annoying me. I wasn't obese but I did add some weight and am taller than average. Next month I will switch it up and add in more fruits because I love summer fruits. Mostly went on the low carb diet to get my summer swimsuit body back :-)
Also to the best of my knowledge I don’t have PC, so I don’t think I need to worry about PC disease progression at this point.
Goodness gracious me. Is there anything that doesn’t cause cancer?
Everything Gives You Cancer...
https://www.youtube.com/watch?v=zbgXOkyF09M
Men
Ignore all prostate advice except this one
You need to get rid of your sperm every 48 to 72 hours
Prostate problems are caused by sperm just sitting around and getting old and your body not having anything to do down there
I’m not going to get into how to get rid of them ; but you need to get rid of them
I can say numerous studies over decades to prove this but I won’t
A good compilation of these studies are in the “undo it” book by Dean Ornish MD
Well, given that I have been on a high fat diet for 8 years now, I will let you know if this is actually an issue. I don’t think so. A year and a half ago I was checked every possible way and nothing seemed wrong. So in 3 years I will do it again. So far, high fat means a thinner healthier me.
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