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New drug breakthrough
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Posted on 10/26/2021 3:51:59 PM PDT by Jedediah

Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published in The Lancet Infectious Diseases found that oral administration of nitazoxanide 600 mg twice daily for five days reduced the duration of clinical symptoms and reduced viral shedding compared to placebo in persons with laboratory-confirmed influenza. The same study also suggested a potential benefit for subjects with influenza-like illness who did not have influenza or other documented respiratory viral infection. From a chemical perspective, nitazoxanide is the scaffold for a new class of drugs called thiazolides. These small-molecule drugs target host-regulated processes involved in viral replication. Nitazoxanide is orally bioavailable and safe with extensive post-marketing experience involving more than 75 million adults and children. A new dosage formulation of nitazoxanide is presently undergoing global Phase 3 clinical development for the treatment of influenza. Nitazoxanide inhibits a broad range of influenza A and B viruses including influenza A(pH1N1) and the avian A(H7N9) as well as viruses that are resistant to neuraminidase inhibitors. It is synergistic with neuraminidase inhibitors, and combination therapy with oseltamivir is being studied in humans as part of ongoing Phase 3 clinical development. Nitazoxanide also inhibits the replication of a broad range of other RNA and DNA viruses including respiratory syncytial virus, parainfluenza, coronavirus, rotavirus, norovirus, hepatitis B, hepatitis C, dengue, yellow fever, Japanese encephalitis virus and human immunodeficiency virus in cell culture assays. Clinical trials have indicated a potential role for thiazolides in treating rotavirus and norovirus gastroenteritis and chronic hepatitis B and chronic hepatitis C. Ongoing and future clinical development is focused on viral respiratory infections, viral gastroenteritis and emerging infections such as dengue fever.


TOPICS:
KEYWORDS: covid; unitedstates

1 posted on 10/26/2021 3:51:59 PM PDT by Jedediah
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To: Jedediah

I don’t want anything they’re selling.


2 posted on 10/26/2021 3:55:23 PM PDT by Pollard (PureBlood)
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To: Jedediah

ANOTHER Tami-Flu?


3 posted on 10/26/2021 3:58:11 PM PDT by acoulterfan
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To: Pollard

Exactly,
Inhibit This!
Clot Shots Kill!


4 posted on 10/26/2021 3:58:38 PM PDT by Big Red Badger (Make His Paths Straight!)
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To: acoulterfan

No, this is an anti-protozoan similar to HCQ or Ivermectin.


5 posted on 10/26/2021 4:05:51 PM PDT by Blood of Tyrants (When elections fail, we will either live under tyranny or rebel and throw it off.)
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To: Jedediah

This is already included in the FLCCC’s early COVID-19 treatment protocol. Like ivermectin, it is a repurposed anti-parasitic


6 posted on 10/26/2021 4:07:55 PM PDT by FlyingFish
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To: Jedediah
Get a load of this from 2020...

Ivermectin and Nitazoxanide Combination Therapy for COVID-19

Don't see any updates. Gee, wonder why...

7 posted on 10/26/2021 4:08:14 PM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: Jedediah

* antiprotozoal agent, aka, anti parasite
* broad-spectrum antiviral drug
* repurposed

Where have I heard this story before?

The ONLY thing that matters is whether it still has patent protection and can make some company a TON of money. If it off-patent, then nobody will recommend it.


8 posted on 10/26/2021 4:09:34 PM PDT by ProtectOurFreedom (“Everything Woke turns to shit.” ~ President Donald Trump)
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To: Jedediah

Ouch. My eyes.

Add some paragraphs FCOL.


9 posted on 10/26/2021 4:12:37 PM PDT by plain talk
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To: mewzilla

Note to conservative kids in need of Halloween costume ideas: Have one kid dress as a box of Ivermectin, one kid can be a cowboy, and any other kids can be horses!

If I get them at my door: EXTRA CANDY!


10 posted on 10/26/2021 4:12:55 PM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: Jedediah
Slightly off topic...

I read an article about BioNTech yesterday at CNBC, the business channel.

BioNTech is a German company that specializes in mRNA vaccines.

Pfizer partnered with BioNTech to get a COVID vaccine to market with the greatest possible speed.

The article mentions that Pfizer has been testing a mRNA influenza vaccine since 2019.

Get that?

Pfizer is still testing its mRNA flu vaccine after THREE years.

But, miraculously, they developed and distributed a mRNA COVID vaccine within 10 months.

11 posted on 10/26/2021 4:29:00 PM PDT by zeestephen
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To: FlyingFish

Yep:

https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Alliance-I-MASKplus-Protocol-ENGLISH.pdf


12 posted on 10/26/2021 4:31:31 PM PDT by LilFarmer
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To: Jedediah

This is no more legible than your word salads.

Grammar makes writing more intelligible.


13 posted on 10/26/2021 4:44:34 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith…)
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To: Jedediah

Try it in bird seed for a few years and get back to us.


14 posted on 10/26/2021 4:52:57 PM PDT by Buttons12 ( )
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To: Jedediah

Just curious. Why is this in the Religion forum?


15 posted on 10/26/2021 4:54:27 PM PDT by Buttons12 ( )
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To: Jedediah

the ANTICOV study in Africa is all about low cost proven drugs. It’s being run in 18 african nations. They’re trialing Nitazoxanide which is pretty cheap. Ivermectin is being widely phased out because of drug resistance.
https://journals.asm.org/doi/10.1128/AAC.00713-16

https://pubmed.ncbi.nlm.nih.gov/27246778/

https://trialsitenews.com/major-sub-saharan-anticov-study-drops-hcq-adopts-nitazoxanide-the-corticosteroid-ciclesonide/


16 posted on 10/26/2021 5:08:48 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: blueplum; All

Nitazoxanide inhibits host enzymes, which impairs the posttranslational processing of viral proteins. It also has inhibitory effects on proinflammatory cytokines.


17 posted on 10/27/2021 11:05:40 AM PDT by Jedediah (The Keys to The Kingdom it)
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To: ProtectOurFreedom; All

In mexico its $30 for 12 500mg pills


18 posted on 10/27/2021 11:07:04 AM PDT by Jedediah (The Keys to The Kingdom it)
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To: blueplum

Amixicile is a lquid form and has amazing
Capabilities to search the body for gram negative bacteria and block their proteins as it wipes them out systemically


19 posted on 10/28/2021 6:56:19 PM PDT by Jedediah (The Keys to The Kingdom it)
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