Posted on 12/07/2021 8:45:19 PM PST by ConservativeMind
With more than 10% of the world's population obese and 40% overweight, obesity constitutes one of the most crucial health challenges. However, existing therapeutic options remain scarce and poorly efficient. Few years ago, scientists discovered that the absorptive surface and function of the gut change due to certain external stimuli, such as exposure to cold. Increasing the food amount elevates the intestinal absorptive surface and function. Mechanistically, this is due to the enhanced expression of PPARα, a regulating protein necessary for the overeating-induced increase in the capacity of the gut to absorb calories. Furthermore, if high amounts of food increase the gut absorptive surface, food restriction can reverse the process and return it close to normal. This phenomenon could be reproduced using pharmacological and genetic approaches, thereby suggesting potential avenues to limit obesity.
Obesity mainly results from an imbalance between energy expenditure and caloric uptake, which takes place in the gut where food, previously broken down, is absorbed and passes into the bloodstream for distribution throughout the body. To absorb enough calories, the intestinal wall is layered with millions of convolutions called villi and microvilli that together could cover the surface of a football field.
A striking and rapid effect
The research team observed that the amount of food consumed was the main regulator of gut length. "We saw a relatively fast and physiologically striking response to elevating the amount of ingested food: gut length increased for over 30%, coupled with a major growth of the villi and microvilli, contributing to an enhanced caloric uptake capacity of the gut." adds Mirko Trajkovski. Importantly, these changes were reversible: when the amount of food was reduced, the gut length and morphology were reverted close to normal.
(Excerpt) Read more at medicalxpress.com ...
Dr. Jason Fung explains it all in his 6 part video series ... FREE on youtube ...
Good info, thanks for posting. And the more I read about careful fasting, the more I think it’s a not a fad but the real deal.
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“With more than 10% of the world’s population obese and 40% overweight, obesity constitutes one of the most crucial health challenges.
However, existing therapeutic options remain scarce and poorly efficient.”
I never saw a picture of people in a concentration camp overweight let alone obese. Same thing with Venezuelan standing in a bread line.
I wonder what was their secret...
I can eat and eat and be lucky if I put on 1 lb
.
This is not hard. Calories are cheap, protein is expensive, Poor people given a certain level of subsistence, opt for the economically available: starch, mostly. Poor people tend to be obese in our culture because they can fill their stomachs with starch bought with food stamps, and oil from fried fast foods.
“Obesity mainly results from an imbalance between energy expenditure and caloric uptake”
That’s all any thinking person needs to know.
Sorry, but this type of research is extremely myopic.
Most people will still go for the easy solution.
Trust me: I know. It’s MUCH more complicated.
I think it’s Dr. Ted Naiman that says we will overeat low quality food until the body’s protein requirement is satisfied.
He’s basically saying it’s not our fault we are fat, it’s that we are choosing the wrong things to eat, thus causing us to overeat.
Increase protein, reduce fat, minimize carbs, and lose weight.
I’ve watched a lot of his interviews. He says the average diet is less than 15% protein, but it should be closer to 35%.
https://www.youtube.com/watch?v=HUiiT-sZ2X4
Rd later.
Most people are fat because they eat to much, eat crap, won’t exercise and don’t care. That’s reality.
Diets don’t work... It’s the mindset that needs to change.
BOOKbump
if you look at any pictures of groups of people in the 1950’s and 60’s in the usa—none were fat. that was a prosperous age. what was their secret?
No USDA, no Food Pyramid.
Based on personal experience, it works. There is a recent book titled, “Life in the Fasting lane”. There are different strategies, but following the easiest schedule can significantly improve your kidney and liver health, and to lose weight.
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