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Successful Xenotransplantation Surgery: Genetically Engineered Pig Kidney Transplanted to Human Body
https://scitechdaily.com ^ | DECEMBER 15, 2021 | By NYU LANGONE HEALTH

Posted on 12/16/2021 8:30:54 AM PST by Red Badger

During a 54-hour observation period after the transplant, Dr. Montgomery and his team tested the kidney tissue and monitored urine production and creatinine levels. All were found to be normal. Credit: Joe Carrotta / NYU Langone Health

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Less than two months after the first breakthrough surgery, NYU Langone Health has performed its second successful investigational xenotransplantation procedure using a genetically engineered pig kidney. This second surgery is a sign of continued progress toward a potential alternative supply of life-saving organs.

Leading the second surgical procedure was Robert Montgomery, MD, DPhil, the H. Leon Pachter, MD, Professor and chair of the Department of Surgery at NYU Langone and director of the NYU Langone Transplant Institute. He transplanted a pig kidney lacking the alpha-gal gene to a recently deceased donor maintained on a ventilator. LiveOnNY, the nonprofit organization that facilitates organ and tissue donation in the greater New York City area, assisted in identifying a generous whole-body donor to help move this landmark research forward.

“We have been able to replicate the results from the first transformative procedure to demonstrate the continued promise that these genetically engineered organs could be a renewable source of organs to the many people around the world awaiting a life-saving gift,” says Montgomery. “There is much more work to do before we begin living human trials, but our preliminary findings give us hope.”

DURING A 54-HOUR OBSERVATION PERIOD AFTER THE TRANSPLANT, DR. MONTGOMERY AND HIS TEAM TESTED THE KIDNEY TISSUE AND MONITORED URINE PRODUCTION AND CREATININE LEVELS. ALL WERE FOUND TO BE NORMAL. CREDIT: JOE CARROTTA / NYU LANGONE HEALTH Robert Montgomery Xenotransplantation Surgery

The procedure, part of an ongoing study, was performed on Monday, November 22, 2021, at an NYU Langone research laboratory in Manhattan. The kidney was procured from a GalSafeTM pig engineered by Revivicor, Inc., a subsidiary of United Therapeutics Corporation. The gene that encodes the glycan known as alpha-gal—which is responsible for a rapid antibody-mediated rejection of porcine organs by humans—was “knocked out” in the donor pig. The pig’s thymus gland, responsible for “educating” the immune system, was fused with the kidney before transplantation.

The kidney was attached to the blood vessels in the upper leg, outside the abdomen, and covered with a protective shield for observation and kidney tissue sampling over a 54-hour period of study. Urine production and creatinine levels—key indicators of a properly functioning kidney—were normal and equivalent to what is seen in a human kidney transplant. Throughout the procedure and subsequent observation period, there were no signs of rejection.

“We continue to make progress with the single-gene knockout xenotransplantation,” says Montgomery. “With additional study and replication, this could be the path forward to saving many thousands of lives each year.”

There are currently more than 90,000 people in the United States awaiting a life-saving kidney transplant, according to the United Network for Organ Sharing.

GalSafeTM is a trademark of Revivicor, Inc.


TOPICS: Business/Economy; Health/Medicine; Pets/Animals; Society
KEYWORDS: dialysis; disease; kidney; renal
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1 posted on 12/16/2021 8:30:54 AM PST by Red Badger
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To: Red Badger

Well, heck. There goes the Chicomms’ side income. What will they do with their non-Han minorities now? Are there that many Apple phones needed that would make up the organlegging losses?


2 posted on 12/16/2021 8:33:19 AM PST by Seruzawa ("The Political left is the Garden of Eden of incompetence" - Marx the Smarter (Groucho))
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To: Red Badger

In case you wondering what the prefix “xeno-” means:

A prefix meaning “alien,” “strange,” “guest”.


3 posted on 12/16/2021 8:36:15 AM PST by cymbeline
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To: cymbeline
....Yeah, riiight................
4 posted on 12/16/2021 8:37:23 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

5 posted on 12/16/2021 8:38:01 AM PST by Magnum44 (...against all enemies, foreign and domestic...)
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To: Red Badger

6 posted on 12/16/2021 8:39:18 AM PST by Magnum44 (...against all enemies, foreign and domestic...)
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To: Red Badger

If you have a pig kidney transplanted to you body will you get the swine flu and other pig dieses.
Read that some place about using animal parts in humans don’t know if true.


7 posted on 12/16/2021 8:40:05 AM PST by Vaduz (women and children to be impacIQ of chimpsted the most.)
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To: Red Badger

8 posted on 12/16/2021 8:41:34 AM PST by Magnum44 (...against all enemies, foreign and domestic...)
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To: Red Badger

PIG MAN!


9 posted on 12/16/2021 8:45:09 AM PST by Psalm 73 ("You'll never hear surf music again" - J. Hendrix)
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To: Red Badger

Not sure how well this tech would be received in Middle East.


10 posted on 12/16/2021 8:48:20 AM PST by AndyTheBear
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To: Psalm 73

11 posted on 12/16/2021 8:49:54 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

No more ham at easter. shame.


12 posted on 12/16/2021 8:50:26 AM PST by kvanbrunt2
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To: AndyTheBear

There will be a lot of converts to Christianity..................


13 posted on 12/16/2021 8:50:38 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

14 posted on 12/16/2021 8:56:14 AM PST by Boogieman
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To: Red Badger

If your body rejects it can you sueeee?


15 posted on 12/16/2021 8:58:25 AM PST by HighSierra5 (The only way you know a commie is lying is when they open their pieholes.p)
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To: Red Badger

There are currently more than 90,000 people in the United States awaiting a life-saving kidney transplant, according to the United Network for Organ Sharing.
= = =

Pigs are going into hiding, heading for NZ.

And they thought those larger pens were just the humans’ love for them.


16 posted on 12/16/2021 9:32:36 AM PST by Scrambler Bob (My /s is more true than your /science (or you might mean /seance))
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To: Red Badger

17 posted on 12/16/2021 9:44:26 AM PST by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
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To: Red Badger

They’ve been transplanting pig heart valves for YEARS now. Have a friend who JUST got one.


18 posted on 12/16/2021 9:54:44 AM PST by FrankRizzo890
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To: Red Badger

What’s this...they’re saying maxine waters donated a kidney?


19 posted on 12/16/2021 10:06:43 AM PST by DPMD ( )
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To: Vaduz

... but you’ll make a fortune truffle hunting.


20 posted on 12/16/2021 10:29:32 AM PST by CTyank
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