Posted on 01/12/2022 4:56:50 AM PST by DoodleBob
Background
The recently emerged SARS-CoV-2 omicron variant raised concerns around potential escape from vaccine-elicited immunity....Here, we report VE of 2 or 3 mRNA-1273 doses against infection and hospitalization with omicron and delta, including among immunocompromised individuals.
Methods This test negative study was conducted at Kaiser Permanente Southern California. Cases were individuals aged ≥18 years testing positive by RT-PCR with specimens collected between 12/6/2021 and 12/23/2021....
...
In analyses of 2-dose VE against delta infection by time since receipt of dose 2, VE at 14-90 days was 82.8% (69.6%-90.3%) and subsequently declined, with VE of 63.6% (51.8%-72.5%) at 91-180 days, 61.4% (56.8%-65.5%) at 181-270 days, and 52.9% (43.7%-60.5%) at >270 days (Table 2, Figure 1).
The 2-dose VE against omicron infection was 30.4% (5.0%-49.0%) at 14-90 days and declined quickly to 15.2% (0.0%-30.7%) at 91-180 days and 0.0% after 180 days.
The 3-dose VE against delta infection was >90%, regardless of whether the third dose was received before or after 10/20/2021. For vaccinated cases, the median number of days from vaccination to positive test date was 35 and 112 days if dose 3 was received after 10/20/2021 or on and before that day, respectively.
However, the VE against omicron infection was 63.6% (57.4%-68.9%) if dose 3 was received after 10/20/2021 (for vaccinated cases, median number of days from vaccination to positive test date was 36 days) and 39.1% (3.8%-61.5%) if received on or before 10/20/2021 (for vaccinated cases, median number of days from vaccination to positive test date was 103 days; Table 2). These estimates were similar in analyses excluding immunocompromised individuals, except that the VE against omicron infection increased to 49.0% (12.6%-70.2%) among immunocompetent individuals who received dose 3 before or on 10/20/21 (Table 2, Figure 2).
(Excerpt) Read more at medrxiv.org ...
When Moderna received its EUA in December 2020, the reported VE was 94%, reflecting only eleven people getting infected after receiving the shots vs 185 in the placebo group out of about 15,000 test subject in each group.
The FDA stated that "To ensure that a widely deployed COVID-19 vaccine is effective, the primary efficacy endpoint point estimate for a placebo-controlled efficacy trial should be at least 50%, and the statistical success criterion should be that the lower bound of the appropriately alpha-adjusted confidence interval around the primary efficacy endpoint point estimate is >30%."
VE for the Moderna shot in this study against Omicron falls below this threshold, and is zero if it's 180 days or more after the second dose. VE against Omicron is only above 50% if the person was boosted after October 20, 2021 and then VE was 63%.
The basis of EUA was for PREVENTION...not reduced symptoms, not keeping you out of the hospital or ground....it was only PREVENTION.
The Moderna shot seems to be effective ONLY if the patient is routinely boosted, and we don't have any clinical trials on the long-term health impacts of frequent boosting. Even with boosting, the VE may still fall below the 50% FDA-determined threshold.
The EUA should be reconsidered if not pulled.
None of the above. We remain-—”NON GMO”.
It is 2024, time to update your vaccination to 14.1
So they are saying it is ineffective against Omicron, but a booster of the exact same stuff will give you some modest protection for about 60 days. Do they really expect people to line up every other month? Ridiculous. Don’t even fight Omicron, let it provide better and longer lasting natural immunity.
Now, the people who took the shots with the promise of strong prevention, are seeing their similarly-dosed friends and family getting infected anyway. The jig is up. Maybe boosting isn't such a great idea, they may think after seeing the data.
HOWEVER, do they want to move from the cool kids table at lunch and sit with the "losers"?
The biggest bullies are the burnouts AND the popular kids.
Do they get boosted now, ASAP for some limited protection against the big bad Omicron? But they're being told it only lasts a couple of months. In mid March they'll be right back here, afraid of being unprotected.
Or do they "take the red pill" and realize the vaccines are not the answer. A never ending succession of booster shots cannot be good/healthy for them long-term. The virus is going to continue to mutate around the vaccines - by definition viruses mutate and the only virus variants that survive are the ones that can survive in the vaccinated. (many doctors warned us about "leaky" vaccines even before these very leaky vaccines came out)
I think you're right though - the MSM has used their usual tactics of demonizing vs praising/showcasing. It is the carrot and stick routine of the social media world. The vaccinated are portrayed as doing the right thing. The un-vaccinated are the cause of all our woes. (remember pandemic of the un-vaccinated?) Those dirty un-vaccinated types must be punished by loss of jobs, healthcare, access to businesses, etc. "Ostracize them!" These people would've done really well burning suspected witches.
They now have a captive audience in their 200+ million vaccinated. The vaccinated are faced with a hard choice - continue on the vaccine treadmill, knowing in just two months you'll be right back to this anxiety level, or admit you were wrong and abandon the group-think. It is usually harder for people to admit they were wrong than continue down an ill-advised path.
I don't think people who took shots are sheep - people with comorbidities, who are older, etc., taking a shot that offers a 94% reduction in infection likelihood seems like a fair trade off vs long-term clinical trials.
But the vective spewed at those who suggested that VE may wane, the potential long-term downside impacts of these shots, and so on, has been disheartening/bordering on angering. A key element of "science" is assiduous disputation...unless it's political science.
Now we have a SCOTUS case, that can potentially erode fundamental civil rights, arising from a mandate to take shots with zero VE against Omicron per this study. SOLELY on the basis of zero VE, the case should be dismissed.
I've seen a few people become red-pilled recently. I hope it continues.
Boosted doesn’t do much. I know of a boosted 96 year old that got it.
With almost 900,000 people dead, and a vaccine that almost entirely prevents death or intubation, they are not going to do that.
The key here is, we should all have a choice to make our own decisions. If someone decides the vaccine is right for them, go for it, best of luck. If someone wants to pass on the vaccine, go for it, best of luck. I've made my position and reasons pretty clear. I'm also willing to listen as new information is coming out all the time. (that's the nature of a drug trial, we learn as we go)
What I have a big problem with is when coercion comes into play. Losing jobs, denied access to healthcare, paying penalties for healthcare, denied access to businesses, forced quarantine camps, etc. That is just wrong, legally and morally.
The dog now bites my kids, they don't want to feed Fido, but I am not getting robbed and the kids aren't getting murdered in my house.
I'll keep the dog, buy thick shirts, and hope little Timmy heals.
“.....continue on the vaccine treadmill, knowing in just two months you’ll be right back to this anxiety level...”
Why, of course! Starbucks knows all about this with over 20,000 locations in the U.S. And now the walk-ins are closed half the time and people are relegated to a 30-minute wait in a drive-thru pickup line - not to mention that most of the help are the freaks of our society.
Thank goodness I kicked that habit!
Its starting to be plain that the vax’s are problematic.
But the politicians who have promoted them, and have used legal force to promote them, cannot politically admit they were wrong. And for sure, the people who bought in to the hoax cannot admit they were wrong. The hospitals who have followed CDC guidelines and killed half their patients can’t admit they were wrong.
So the climb-down is going to be long and slow. They weren’t wrong, they were wrong for the right reasons, they were right but there were variants, they were right but not enough people took the shots, they were right but Trump and the right-wingers...
FYI
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